Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

Facer, Paul, Casula, Maria A, Smith, Graham D, Benham, Christopher D, Chessell, Iain P, Bountra, Chas, Sinisi, Marco, Birch, Rolfe and Anand, Praveen (2007) Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurology, 7. p. 11.

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Transient receptor potential (TRP) receptors expressed by primary sensory neurons mediate thermosensitivity, and may play a role in sensory pathophysiology. We previously reported that human dorsal root ganglion (DRG) sensory neurons co-expressed TRPV1 and TRPV3, and that these were increased in injured human DRG. Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models. However, the role of TRPs in common clinical sensory neuropathies needs to be established.

Item Type	Article
Identification Number	10.1186/1471-2377-7-11
Keywords	axons, cells, cultured, diabetic neuropathies, gene expression regulation, humans, peripheral nerve injuries, peripheral nerves, reference values, trpm cation channels, trpv cation channels
Date Deposited	15 May 2025 12:20
Last Modified	03 Feb 2026 07:09