Efficacy, tolerability and consumer acceptability of terbinafine topical spray versus terbinafine topical solution : a phase IIa randomised, observer-blind, comparative study

Brown, Marc, Evans, Charles, Muddle, Andrew, Turner, Rob, Lim, Sian, Reid, Jessica and Traynor, M.J. (2013) Efficacy, tolerability and consumer acceptability of terbinafine topical spray versus terbinafine topical solution : a phase IIa randomised, observer-blind, comparative study. American Journal of Clinical Dermatology, 14 (5). pp. 413-419. ISSN 1179-1888
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Tinea pedis is one of the world's most prevalent dermatophyte infections. MedSprayTM tinea pedis 1 % w/w (topical spray) is a novel, easy to use propellant based spray formulation containing 1% w/w terbinafine, requiring no manipulation at the site of infection. This is in contrast to the only formulation currently approved in Europe for single application (non are approved in the US for single use) which is LamisilĀ® Once 1 % w/w (topical solution), containing 1% w/w terbinafine hydrochloride which requires manipulation on the affected area. The aim of this phase IIa randomised, observer-blind, comparative study was to evaluate the efficacy, tolerability and consumer acceptability of a topical spray versus a topical solution in the treatment of tinea pedis.

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