Mechanisms contributing to visceral hypersensitivity : focus on splanchnic afferent nerve signalling

Deiteren, Annemie, de Man, Joris, Keating, Christopher, Jiang, Wen, de Schepper, Heiko, Pelckmans, Paul, Francque, Sven and de Winter, Benedicte (2015) Mechanisms contributing to visceral hypersensitivity : focus on splanchnic afferent nerve signalling. Neurogastroenterology and Motility, 27 (12). pp. 1709-1720. ISSN 1350-1925

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Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis.

Item Type	Article
Identification Number	10.1111/nmo.12667
Additional information	This is the peer reviewed version of the following article: Deiteren, A., De Man, J. G., Keating, C., Jiang, W., De Schepper, H. U., Pelckmans, P. A., Francque, S. M. and De Winter, B. Y. (2015), Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signaling. Neurogastroenterology & Motility, 27: 1709–1720, which has been published in final form at doi:10.1111/nmo.12667. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords	afferent nerve signalling, colitis, mechanosensitivity, splanchnic nerves, tnbs, visceral hypersensitivity
Date Deposited	15 May 2025 12:56
Last Modified	04 Feb 2026 01:03