Missing steps in a staircase : a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials

Dimairo, Munya, Boote, Jonathan, Julious, Steven A., Nicholl, Jon and Todd, Susan (2015) Missing steps in a staircase : a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials, 16: 430. ISSN 1745-6215

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Despite the promising benefits of adaptive designs (ADs), their routine use, especially in confirmatory trials, is lagging behind the prominence given to them in the statistical literature. Much of the previous research to understand barriers and potential facilitators to the use of ADs has been driven from a pharmaceutical drug development perspective, with little focus on trials in the public sector. In this paper, we explore key stakeholders’ experiences, perceptions and views on barriers and facilitators to the use of ADs in publicly funded confirmatory trials

Item Type	Article
Identification Number	10.1186/s13063-015-0958-9
Additional information	Date of Acceptance: 14/09/2015. © 2015 Dimairo et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Date Deposited	15 May 2025 12:57
Last Modified	18 Feb 2026 20:11