Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis

Jolly, Elaine C, Clatworthy, Menna R, Lawrence, Christopher, Nathan, Paul D and Farrington, Ken (2009) Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis. NDT Plus, 2 (4). pp. 300-2. ISSN 1753-0784

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Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, of immune-mediated nephritis following the administration of Tremelimumab (CP-675, 206), an anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody. High-dose steroid therapy led to a rapid improvement in renal function, avoiding the need for renal replacement therapy.