Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells

Baydoun, A. R. and Morgan, D. M. L. (1998) Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells. British Journal of Pharmacology, 125 (7). pp. 1511-1516. ISSN 0007-1188
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We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages.
Item Type Article
Identification Number 10.1038/sj.bjp.0702231
Additional information Original article can be found at: --http://www.nature.com/bjp/index.html--Copyright British Pharmacological Society and Nature Publishing Group DOI : 10.1038/sj.bjp.0702231
Date Deposited 15 May 2025 11:44
Last Modified 18 Feb 2026 19:53

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