The East Asian Paradox : An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Kim, Hyun Kuk, Tantry, Udaya S., Smith, Sidney C., Jeong, Myung Ho, Park, Seung Jung, Kim, Moo Hyun, Lim, Do Sun, Shin, Eun Seok, Park, Duk Woo, Huo, Yong, Chen, Shao Liang, Bo, Zheng, Goto, Shinya, Kimura, Takeshi, Yasuda, Satoshi, Chen, Wen Jone, Chan, Mark, Aradi, Daniel, Geisler, Tobias, Gorog, Diana A., Sibbing, Dirk, Lip, Gregory Y.H., Angiolillo, Dominick J., Gurbel, Paul A. and Jeong, Young Hoon (2020) The East Asian Paradox : An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease. Thrombosis and haemostasis, 121 (04). p. 11. ISSN 0340-6245

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East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.

Item Type	Article
Identification Number	10.1055/s-0040-1718729
Additional information	© 2020. Thieme. All rights reserved. Georg Thieme Verlag KG. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1055/s-0040-1718729.
Keywords	antiplatelet therapy, bleeding risk, direct oral anticoagulants, ischemic risk, race, hematology
Date Deposited	15 May 2025 14:25
Last Modified	01 Mar 2026 01:03