Assessment of endogenous fibrinolysis in clinical using novel tests - Ready for clinical roll-out?

Gue, Ying X., Ding, Wern Yew, Lip, Gregory Y H and Gorog, Diana (2021) Assessment of endogenous fibrinolysis in clinical using novel tests - Ready for clinical roll-out? SN Applied Sciences, 3 (5): 524. ISSN 2523-3971
Copy

The occurrence of thrombotic complications, which can result in excess mortality and morbidity, represent an imbalance between the pro-thrombotic and fibrinolytic equilibrium.The mainstay treatment of these complications involves the use of antithrombotic agents but despite advances in pharmacotherapy, there remains a significant proportion of patients who continue to remain at risk.Endogenous fibrinolysis is a physiological counter-measure against lasting thrombosis and may be measured using several techniques to identify higher risk patients who may benefit from more aggressive pharmacotherapy. However, the assessment of the fibrinolytic systemis not yet accepted into routine clinical practice.In this review, we will revisit the different methods of assessing endogenous fibrinolysis (factorial assays, turbidimetric lysis assays, viscoelastic and the global thrombosis tests), including the strengths, limitations, correlation to clinical outcomes of each method and howwe might integrate the assessment of endogenous fibrinolysis into clinical practice in the future.


picture_as_pdf
Gue2021_Article_AssessmentOfEndogenousFibrinol.pdf
subject
Published Version
Available under Creative Commons: BY 4.0

View Download
picture_as_pdf

Submitted Version


Atom BibTeX OpenURL ContextObject in Span OpenURL ContextObject Dublin Core MPEG-21 DIDL Data Cite XML EndNote HTML Citation METS MODS RIOXX2 XML Reference Manager Refer ASCII Citation
Export

Downloads