UH Research Archive: Recent submissions
Now showing items 9781-9800 of 11146
-
The Effects of Paranoid and or Persecutory Delusions on Feelings of Social Inclusion and Exclusion
(2010-05-25)Background: Current psychological theories of persecutory delusions appear limited in being able to explain their interpersonal nature. Unanswered questions include why the content of delusions mostly involves persecution ... -
Eating Disorder and the Experience of Self: An Interpretative Phenomenological Analysis
(2010-05-24)Aims: Quantitative research and clinical observations have long supported a link between the eating disorders and disturbances of self / identity. However, less is known about the process of how this comes about, and little ... -
Burnout, coping and job satisfaction in service staff treating opioid addicts : from Athens to Zurich
(2010)The Treatment-systems Research on European Addiction Treatment study (TREAT-project) is a longitudinal multicenter study on predominantly opioid-dependent patients and their health-care system in six European cities. As ... -
Making Sense of e-HRM: Technological Frames, Value Creation and Competitive Advantage
(2010-05-21)A wide range of Human Resources (HR) processes and information can now be managed and devolved to line managers and employees using e-HRM (‘electronic Human Resource Management’). E-HRM has been defined as “An umbrella ... -
Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition
(1995)Objectives: To investigate the relationship between polymorphisms in the angiotensin converting enzyme (ACE), angiotensinogen (AGT) and type 1 angiotensin-II (AT1R) genes and (1) quantitative variations in blood pressure ... -
Alpha-blockade and calcium antagonism : an effective and well-tolerated combination for the treatment of resistant hypertension
(1995)Objective: To test whether the combination of calcium antagonism is additive with the other newer antihypertensives, namely [alpha]-blockers and angiotensin converting enzyme (ACE) inhibitors. Design: Three-way double-blind, ... -
Bovril and moclobemide: a novel therapeutic strategy for central autonomic failure
(1994)The consumption of tyramine-containing foods is contraindicated in patients on classic monoamine oxidase (MAO) inhibitors. We report successful therapeutic use of moclobemide (a MAO-A selective inhibitor) plus controlled ... -
Optimisation of antihypertensive treatment by crossover rotation of four major classes
(1999)Most comparisons of antihypertensive drugs aee undertaken in parallel groups. We undertook a crossover rotation of the four main classes of antihypertensive drugs, in untreated young hypertensive patients, to assess the ... -
[beta]2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians
(2000)Objective: The amino-terminal polymorphisms, Arg16Gly and Gln27Glu, of the [beta]2-adrenergic receptor ([beta]2AR) have been shown to affect regulation of the receptor expression by an agonist in cell culture studies. The ... -
The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects
(2000)Mutation scanning of the b1-adrenoceptor gene has identified a polymorphism, G389R, that markedly affects G-protein coupling of the receptor and resulting cAMP production. We have investigated the effect of this functionally ... -
Association of the Gsα Gene With Essential Hypertension and Response to ß-Blockade
(1999)We examined whether the GNAS1 locus, encoding the Gs protein α-subunit (Gsα), is implicated in the genetic causes of essential hypertension. A common silent polymorphism (ATTATC, Ile131) was identified in exon 5 of the Gsα ... -
A prospective study of the effects of prolonged timolol therapy on α- and β-adrenoceptor and angiotensin II receptor mediated responses in normal subjects
(1997)Aims Long-term treatment with β1-selective adrenergic antagonists gives rise to cross-sensitisation of cardiac β2-adrenoceptor responses, with no corresponding alteration in β1-adrenoceptor responses. We performed a ... -
Beta adrenoreceptor subtype cross regulation in the human heart
(1993)OBJECTIVES--To find out in a prospective study whether beta 1 blocker treatment causes selective beta 2 adrenoreceptor sensitisation, and to find whether such sensitisation is confined to the heart. DESIGN--A placebo ... -
Prolonged effect of CGRP in Raynaud's patients : a double-blind randomised comparison with prostacyclin
(1991)1. Calcitonin gene related peptide (CGRP) is a potent endogenous vasodilator to which we have previously demonstrated a specific hypersensitivity in skin blood flow in the hands in patients with Raynaud's disease. 2. We ... -
A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma : comparison of levels in patients with essential hypertension and normotensive control subjects
(1990)1. A radioimmunoassay has been developed for measuring endothelin-like immunoreactivity in human plasma using an antibody raised against endothelin-1 which also cross-reacts with big endothelin-1 and endothelin-2 but not ... -
Selective suprasensitivity to calcitonin-gene-related peptide in the hands in Raynaud's phenomenon
(1989)The effects of intravenous infusion of three vasodilators on skin blood flow were studied in eight patients with Raynaud's phenomenon and eight controls, matched for age and sex, by means of the non-invasive technique of ... -
HAT-P-14b: A 2.2Mj exoplanet transiting a bright F star
(2010)We report the discovery of HAT-P-14b, a fairly massive transiting extrasolar planet orbiting the moderately bright star GSC 3086-00152 (V = 9.98), with a period of P = 4.627669 ± 0.000005 days. The transit is close to ... -
Laxative use in care homes
(2010)Aim. This paper is a report of an investigation into the factors associated with laxative-taking by older people in care homes. Background. Constipation is a common source of discomfort, pain and morbidity for care home ... -
Using Web 2.0 Technologies to Engage With and Support the net Generation of Learners
(2007)Web 2.0 social software offer new pedagogic opportunities to support and empower the Net generation of learners to create their own personal learning agenda and dynamic learning environments. This paper presents learners ...