Author

Date Item Type No Grouping

Article

Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetes. (2020) Yousif Shamsaldeen, Lisa Lione and Christopher Benham

Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds. (2020) Bhavani Anagani, Jagbir Singh, Jatinder Bassin, Gurdyal Besra, Christopher Benham, Tummala Rama Krishna Reddy, Jonathan Cox and Madhu Goyal

Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease : contractile dysfunction in MPTP-treated primate ileum. (2019) E Coletto, John S Dolan, Sara Pritchard, Alex Gant, Atsuko Hikima, Michael J Jackson, Christopher Benham, K. Ray Chaudhuri, Sarah Rose, Peter Jenner and Mahmoud Iravani

Dysfunction in nitric oxide synthesis in streptozotocin treated rat aorta and role of methylglyoxal. (2019) Yousif Shamsaldeen, Mahdi Alsugoor, Lisa Lione and Christopher Benham

Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats. (2018) Yousif Shamsaldeen, Rosemary Ugur, Christopher Benham and Lisa Lione

Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia. (2017) Sara Pritchard, Atsuko Hikima, Michael Jackson, Lisa Lione, Christopher Benham, K. Ray Chaudhuri, Sarah Rose, Peter Jenner and Mahmoud Iravani

Synthesis and Spectral Characterization of Benzo[6,7] [1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives. (2016) Jatinder Bassin, Bhavani Anagani, Christopher Benham, Madhu Goyal, Maryam Hashemian and Ute Gerhard

Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies. (2016) Yousif Shamsaldeen, Louise MacKenzie, Lisa Lione and Christopher Benham

Selective inhibition of NADPH Oxidase reverses the over contraction of diabetic rat aorta. (2014) Atif ur Rehman, Elma Dugic, Christopher Benham, Lisa Lione and Louise Susan MacKenzie

Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. (2007) Paul Facer, Maria A Casula, Graham D Smith, Christopher D Benham, Iain P Chessell, Chas Bountra, Marco Sinisi, Rolfe Birch and Praveen Anand

Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. (2006) G. Mukerji, Y. Yiangou, S. Corcoran, I. S. Selmer, G.D. Smith, C.D. Benham, C. Bountra, S. K. Agarwal and P. Anand

Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting Ih. (2003) A. Ray, C.D. Benham, J.C. Roberts, C.H. Gill, C. Lanneau, D.P. Gitterman, M. Harries, J.B. Davis and C.H. Davies

TRPV channels as temperature sensors. (2003) C.D. Benham, M.J. Gunthorpe and J.B. Davis

Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. (2002) A. Riccio, C. Mattei, R.E. Kelsell, A.D. Medhurst, A. R. Calver, A.D. Randall, J.B. Davis, C.D. Benham and M. N. Pangalos

Heat-evoked activation of TRPV4 channels in an HEK-293 cell expression system and in native mouse aorta endothelial cells. (2002) H. Watanabe, J. Vriens, S. H. Suk, C.D. Benham, G. Droogmans and B. Nilius

The neuroprotective role of monocarboxylate transport inhibition during glucose deprivation in slice cultures of rat hippocampus. (2001) H. Cater, C.D. Benham and L. Sundstrom

Mutation of Histidine 286 of the human P2X4 receptor leads to loss of pH sensitivity. (2000) C. Clarke, C.D. Benham, A. Bridges, G. Sanger, A. R. George and H.J. Meadows

Time course of the initial [Ca2+]i response to extracellular ATP in smooth muscle depends on [Ca2+]e and ATP concentration. (1998) M.G. Mahoney, L. L. Slakey, C.D. Benham and D. J. Gross

Specific induction of intracellular calcium oscillations by complement membrane attack on oligodendroglia. (1993) A. Wood, M. Wing, C.D. Benham and D. A. S. Compston

Inward rectification in freshly isolated single smooth muscle cells of the rabbit jejunum. (1987) C.D. Benham, T.B. Bolton, J.S. Denbigh and R.J. Lang

SB-334867-A antagonises orexin mediated excitation in the locus coeruleus. (2002) E.M. Soffin, M.L. Evans, C.H. Gill, M. Harries, C.D. Benham and C.H. Davies

The mechanism of action of Ba2+ and TEA on single Ca2+-activated K+-channels in arterial and intestinal smooth muscle cell membranes. (1985) C.D. Benham, T.B. Bolton, R.J. Lang and T. Takewaki

Isolation of potassium, chloride and non selective cation conductances activated by noradrenaline in rabbit ear artery cells. (1990) T. Amedee, C.D. Benham, T.B. Bolton, N.G. Byrne and W.A. Large

Furosemide inhibits regenerative cortical spreading depression in anaesthetised cats. (1997) S.J. Read, M.I. Smith, C.D. Benham, A.J. Hunter and A.A. Parsons

Caspase inhibitors are functionally neuroprotective against oxygen glucose deprivation induced CA1 death in organotypic hippocampal slices. (2000) A. Ray, D. Owen, M.L. Evans, J.B. Davis and C.D. Benham

Characterization of the human HCN1 subunit and its inhibition by capsazepine. (2004) C.H. Gill, S.A. Bates, D. Owen, P. Larkman, W. Cairns, S. Yusuf, P. Murdock, P. Strijbos, A. Powell, C.D. Benham and C.H. Davies

Orexin-A activates locus coeruleus cell firing and increases arousal in the rat. (1999) J.J. Hagan, R.A. Leslie, S. Patel, M.L. Evans, T.A. Wattam, S. Holmes, C.D. Benham, S.G. Taylor, C. Routledge, P. Hemmati, R.P. Munton, T.E. Ashmeade, A.S. Shah, J.P. Hatcher, P.D. Hatcher, D.N.C. Jones, M.I. Smith, D.C. Piper, A.J. Hunter, R.A. Porter and N. Upton

Lactate and glucose as energy substrates during, and after, oxygen deprivation in rat hippocampal acute and cultured slices. (2003) H. Cater, A. Chandratheva, C.D. Benham, B. Morrison and L. Sundstrom

Amyloid β-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. (2005) E. Fonfria, I.C.B. Marshall, I. Boyfield, S.D. Skaper, J.P. Hughes, D. Owen, W. Zhang, B.A. Miller, C.D. Benham and S. McNulty

Stretch-induced injury in organotypic hippocampal slice cultures reproduces in vivo post-traumatic neurodegeneration : role of glutamate receptors and voltage-dependent calcium channels. (2007) Heather L Cater, Daniel Gitterman, Susan M Davis, Christopher D Benham, Barclay Morrison and Lars E Sundstrom

Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette. (2008) Daniel Sánchez, Nick Johnson, Chao Li, Pavel Novak, Johannes Rheinlaender, Yanjun Zhang, Uma Anand, Praveen Anand, Julia Gorelik, Gregory I Frolenkov, Christopher Benham, Max Lab, Victor P Ostanin, Tilman E Schäffer, David Klenerman and Yuri E Korchev

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. (2008) Uma Anand, William R Otto, Daniel Sanchez-Herrera, Paul Facer, Yiangos Yiangou, Yuri Korchev, Rolfe Birch, Christopher Benham, Chas Bountra, Iain P Chessell and Praveen Anand

Calpain activation and inhibition in organotypic rat hippocampal slice cultures deprived of oxygen and glucose. (1999) C. Brana, C.D. Benham and L. Sundstrom

SB 205384 slows the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. (1997) H.J. Meadows, M. Harries, M. Thompson and C.D. Benham

Sensitivity to conotoxin block of splice variants of rat rbBII subunit of the N-type calcium channel co-expressed with different beta-subunits in Xenopus oocytes. (1999) H.A. Meadows and C.D. Benham

Recent advances in the molecular understanding of voltage gated Ca2+ channels. (1999) C.D. Benham and A.D. Randall

TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. (2004) E. Fonfria, I.C.B. Marshall, C.D. Benham, I. Boyfield, J.D. Brown, K. Hill, J.P. Hughes, R.E. Kelsell, S.D. Skaper, A.M. Scharenberg and S. McNulty

Simple recipe for blocking ion channels. (2005) C.D. Benham

Sensing of lysophospholipids by TRPC5 calcium channel. (2006) Philippa K Flemming, Alexandra M Dedman, Shang-Zhong Xu, Jing Li, Fanning Zeng, Jacqueline Naylor, Christopher D Benham, Alan N Bateson, Katsuhiko Muraki and David J Beech

Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of rabbit. (1986) C.D. Benham and T.B. Bolton

ATP gated channels in vascular smooth muscle cells. (1990) C.D. Benham

Flufenamic acid is a pH-dependent antagonist of TRPM2 channels. (2004) K. Hill, C.D. Benham, S. McNulty and A.D. Randall

Patch and whole cell voltage-clamp studies on single smooth muscle cells. Cellular Calcium Control Mechanisms. (1986) T.B. Bolton, R.J. Lang, T. Takewaki and C.D. Benham

Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery. (1988) C.D. Benham and R.W. Tsien

Rank-order inhibition by ω-conotoxins in human and animal autonomic nerve preparations. (2000) G. Sanger, E.S. Ellis, M. Harries, N.S. Tilford, K.A. Wardle and C.D. Benham

A hyperspectral fluorescence lifetime probe for skin cancer diagnosis. (2007) P A A De Beule, C Dunsby, N P Galletly, G W Stamp, A C Chu, U Anand, P Anand, C.D. Benham, A Naylor and P M W French

Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy. (2007) Daniel Sánchez, Uma Anand, Julia Gorelik, Christopher D Benham, Chas Bountra, Max Lab, David Klenerman, Rolfe Birch, Praveen Anand and Yuri Korchev

SB 201823-A antagonises calcium currents in central neurons and reduces the effects of focal ischaemia in rats and mice. (1995) F.C. Barone, P. G. Lysko, W.J. Price, G. Feuerstein, C.D. Benham, D. C. Harrison, M. Harries, S. J. Bailey and A.J. Hunter

The selective N type calcium channel antagonist omega conotoxin MVILA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal slice cultures. (1996) A. K. Pringle, L. Sim, J. Kennedy, G. J. C. Wilde, C.D. Benham, F. Iannotti and L. Sundstrom

An in-vitro model of traumatic brain injury utilising two-dimensional stretch of organotypic hippocampal slice cultures. (2006) B. Morrison III, H. Cater, C.D. Benham and L. Sundstrom

Cloning, localisation and functional expression of the human ortholgue of the TREK-1 potassium channel. (2000) H.J. Meadows, C.D. Benham, W. Cairns, I. Gloger, C. Jennings, A.D. Medhurst, P. Murdock and C.G. Chapman

ATP-activated channels gate calcium entry in single smooth muscle cells dissociated from rabbit ear artery. (1989) C.D. Benham

Calcium activated K-channels in single dispersed smooth muscle cells or rabbit jejunum and guinea-pig mesenteric artery. (1986) C.D. Benham, T.B. Bolton, R.J. Lang and T. Takewaki

ATP joins the fast lane. (1992) C.D. Benham

Vanilloid and TRP channels: a family of lipid gated cation channels. (2002) C.D. Benham, J.B. Davis and A.D. Randall

Two types of calcium channels in single smooth muscle cells from rabbit ear artery - studied with whole cell and single channel recordings. (1987) C.D. Benham, P. Hess and R.W. Tsien

Changes in cytoplasmic calcium induced by purinergic P2X receptor activation in vascular smooth muscle cells and sensory neurons. (1991) C.D. Benham, M.M. Bouvier and M.L. Evans

Alterations in [Ca2+] mediated by sodium-calcium exchange in smooth muscle cells isolated from the guinea-pig ureter. (1989) C.D. Benham and P.I. Aaronson

[3H]- resiniferatoxin autoradiography in the CNS of wild type and TRPV1 null mice defines TRPV1 (VR1) protein distribution. (2004) J.C. Roberts, J.B. Davis and C.D. Benham

Cloning and functional expression of a human orthologue of the rat vanilloid receptor-1. (2000) P. Hayes, H.J. Meadows, M.J. Gunthorpe, M. Harries, M. Duckworth, W. Cairns, D. C. Harrison, K. Ellington, R. Prinjha, A. Barton, A.D. Medhurst, G.D. Smith, S. Topp, G. Sanger, O. Jenkins, C.D. Benham, I. Gloger, C. E. Clarke, P. Murdock, J. Terrett, A. D. Randall, I. S. Gloger and J. B. Davis

Lack of effect of the novel anticonvulsant SB 204269 on voltage dependent currents in neurones cultured from rat hippocampus. (1999) M. Caesar, M.L. Evans and C.D. Benham

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurons. (2006) K. Hill, N. Tigue, R.E. Kelsell, C.D. Benham, S. McNulty, M. Schaefer and A.D. Randall

Activation of TRPV4 channels (hVRL-2/mTrp12) by phorbol derivatives. (2002) H. Watanabe, J.B. Davis, D. Smart, J.C. Jerman, G.D. Smith, P. Hayes, J. Vriens, W. Cairns, U. Wissenbach, J. Prenen, G.D. Flockerzi, G. Droogmans, C.D. Benham and B. Nilius

Tissue distribution profiles of the human TRPM cation channel family. (2006) E. Fonfria, P. Murdock, F.S. Cusdin, C.D. Benham, R.E. Kelsell and S. McNulty

A method for combining propidium iodide staining with immunohistochemistry. (2002) C. Brana, C.D. Benham and L. Sundstrom

The effects of SB 206284A, a novel neuronal Ca channel antagonist in models of cerebral ischaemia. (1997) N. Wood, F.C. Barone, C.D. Benham, T.H. Brown, C.A. Campbell, D.C. Cooper, M.L. Evans, G. Feuerstein, T.C. Hamilton, M. Harries, P.D. King, J.E. Meakin, J.L. Murkitt, S. Patel, W.J. Price, J.C. Roberts, A.L. Rothaul, N.A. Samson, S.J. Smith and A.J. Hunter

Calcium Efflux mechanisms following depolarisation evoked calcium transients in cultured rat sensory neurones. (1992) C.D. Benham, M.L. Evans and C.J. McBain

SB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemia. (1993) C.D. Benham, T.H. Brown, D.C. Cooper, M.L. Evans, M. Harries, H.J. Herdon, J.E. Meakin, K.L. Murkitt, S. Patel, J.C. Roberts, A.L. Rothaul, S.J. Smith, N. Wood and A.J. Hunter

Voltage-gated and agonist mediated rises in intracellular Ca in rat clonal pituitary cells (GH3) held under voltage clamp. (1989) C.D. Benham

Patch-clamp studies of slow potential sensitive potassium channels in longitudinal smooth muscle cells of rabbit. (1983) C.D. Benham and T.B. Bolton

Patch and whole cell voltage-clamp of single mammalian visceral and vascular smooth muscle cells. (1985) T.B. Bolton, R.J. Lang, T. Takewaki and C.D. Benham

Acetylcholine activates a non-specific inward current in single mammalian smooth muscle cells. (1985) C.D. Benham, T.B. Bolton and R.J. Lang

SB 205384: A GABA-A receptor modulator with novel mechanism of action that shows subunit selectivity. (1998) H.J. Meadows, T.B. Blackburn, D. Pritchett and C.D. Benham

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. (1987) C.D. Benham and R.W. Tsien

Tetrodotoxin resistant sodium channels in pain. (2001) C.D. Benham

The diversity in the vanilloid receptor family of ion channels. (2002) M.J. Gunthorpe, C.D. Benham, A.D. Randall and J.B. Davis

Control of secretion in anterior pituitary cells - Linking ion channels, messengers and exocytosis. (1988) W.T. Mason, S.R. Rawlings, P. Cobbett, S.K. Sikdar, R. Zorec, S.N. Akerman, C.D. Benham, M. Berridge, T. Cheek and R.B. Moreton

Action of extracellular adenosine triphoshate in single smooth muscle cells dispersed from the rabbit ear artery. (1987) C.D. Benham, T.B. Bolton, N.G. Byrne and W.A. Large

Calcium influx stimulated by activation of ATP receptors on sensory neurons from rat dorsal root ganglia. (1991) M.M. Bouvier, M.L. Evans and C.D. Benham

SK&F 96365, a novel inhibitor of receptor mediated calcium entry. (1990) J. E. Merritt, P. A. Armstrong, C.D. Benham, T. J. Hallam, R. J. Jacob, A. Jaxa-Chamiec, B. K. Leigh, S.A. McCarthy, K.E. Moores and T. J. Rink

mRNA distribution analysis of TRPC family in human CNS and peripheral tissues. (2002) A. Riccio, A.D. Medhurst, C. Mattei, R.E. Kelsell, A. R. Calver, A.D. Randall, C.D. Benham and M. N. Pangalos

TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia. (2006) E. Fonfria, C. Mattei, K. Hill, J.T. Brown, A.D. Randall, C.D. Benham, S.D. Skaper, C.A. Campbell, B. Crook, P.R. Murdoch, J.M. Wilson, F.P. Murio, D. Owen, P.L. Tilling and S. McNulty

Characterisation of SB-221420-A, a neuronal Ca and Na channel antagonist in experimental models of stroke. (2000) C.A. Campbell, F.C. Barone, C.D. Benham, S.J. Hadingham, M. Harries, J.M. Hills, V.A. Lewis, A.A. Parsons, R.F. White and A.J. Hunter

Conference or Workshop Item

NADPH oxidase is the source of ROS in STZ rat aorta : use of the novel highly selective NOX inhibitor VAS2870. (2013) Elma Dugic, Yousif Shamsaldeen, Christopher David Benham and Louise MacKenzie

Other

Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats : Supplement to Diabetes Metab Res Rev. 34(5):e2995. (2019) Lisa Lione, Christopher Benham and Yousif Shamsaldeen

The spontaneous and neurogenic contractile responses of the isolated bladder smooth muscle are markedly enhanced in MPTP treated common marmoset (Callithrix jacchus). (2013) Sara Pritchard, Michael Jackson, Lisa Lione, Christopher Benham, Sarah Rose, Peter Jenner and Mahmoud M. Iravani

Synthesis and evaluation of chalcones and isobenzofuranones for their antimycobacterial activity. (2015) Bhavani Anagani, Jatinder Bassin, Christopher Benham and Madhu Goyal