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Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes
(2010-04)
The degeneration of dopaminergic neurons in the substantia nigra has been linked to the formation of the endogenous neurotoxin 5-S-cysteinyl-dopamine. Sulforaphane (SFN), an isothiocyanate derived from the corresponding ...
Wide-field motion integration in fly VS cells : insights from an inverse approach
(2010)
Fly lobula plate tangential cells are known to perform wide-field motion integration. It is assumed that the shape of these neurons, and in particular the shape of the subclass of VS cells, is responsible for this type of ...
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
(2009-04-01)
Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) ...
Systematic mapping between dendritic function and structure
(2009)
For many classes of neurons, the relationship between computational function and dendritic morphology remains unclear. To gain insights into this relationship, we utilize an inverse approach in which we optimize model ...
Non-parametric algorithmic generation of neuronal morphologies
(2008-12)
Generation algorithms allow for the generation of Virtual Neurons (VNs) from a small set of morphological properties. The set describes the morphological properties of real neurons in terms of statistical descriptors such ...
Complement C2 receptor inhibitor trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi
(2008-11-01)
The ability to resist complement differs between the Y and Colombiana Trypanosoma cruzi strains. We found that the Y strain of T. cruzi was more able to resist the classical and lectin pathways of complement activation ...
Glial metabolism of quercetin reduces its neurotoxic potential
(2008-10-15)
The neuroprotective effects of flavonoids will ultimately depend on their interaction with both neuronal and glial cells. In this study, we show that the potential neurotoxic effects of quercetin are modified by glial cell ...
Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1 : implications for Parkinson's disease and protection by polyphenols
(2008-08-15)
Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-c ...
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons
(2008)
Cannabinoid receptor 2 (CB2) agonists provide the potential for treating chronic pain states without CNS effects associated with CB1 receptor activation. Animal models suggest that they act mainly via non-neuronal cells, ...
Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis
(2008-01)
Bone marrow-derived mesenchymal stem cells (MSCs) have shown great promise for cardiac repair. However, poor viability of transplanted MSCs within the ischemic heart has limited their therapeutic potential. Our previous ...