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BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates
(2019-06-01)
Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and ...
A stepwise neuron model fitting procedure designed for recordings with high spatial resolution : Application to layer 5 pyramidal cells
(2018-01-01)
Background Recent progress in electrophysiological and optical methods for neuronal recordings provides vast amounts of high-resolution data. In parallel, the development of computer technology has allowed simulation of ...
The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy
(2017-08-01)
There is an urgent need to develop new combination therapies beyond existing surgery, radio- and chemo-therapy, perhaps initially combining chemotherapy with the targeting specificities of immunotherapy. For this, strategies ...
Allopurinol as a therapeutic option in cardiovascular disease
(2017-04-01)
Epidemiological studies indicate that hyperuricaemia is an independent risk factor for cardiovascular disease. Alongside uric acid formation, increased xanthine oxidase activity also results in the formation of oxidative ...
Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro
(2017-03-31)
Giardia intestinalis (G.I), is an anaerobic protozoan and the aetiological agent of giardiasis, a diarrhoea present worldwide and associated with poverty. G.I has a simple life cycle alternating between cyst and trophozoite. ...
Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E
(2017-01-20)
CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has ...
Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E
(2017-01-20)
CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has ...
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
(2015-12-01)
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 ...
Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction : role of vorapaxar
(2015-07-22)
Acute myocardial infarction (AMI) is generally attributed to coronary atherothrombotic disease. Platelet activation is essential for thrombus formation and is thus an important target for pharmacological intervention to ...
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
(2015-05-28)
Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of ...