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An ovine Major histocompatibility complex DRB1 allele is associated with low faecal egg counts following natural, predominantly Ostertagia circumcincta infection
Schwaiger, F.W.; Gostomski, D.; Stear, M.J.; Duncan, J.L.; McKellar, Quintin; Epplen, J.T.; Buitkamp, J. (1995-07)Infection with Ostertagia circumcincta is a major constraint on sheep production in temperate areas of the world. A potential control strategy is the use of genetically resistant sheep. Therefore we examined the association ... -
Parasitosis internas del caballo, Sustrai Revista
Sarasola, P.; McKellar, Quintin (1991) -
Penetration of antibiotics into specific sites
McKellar, Quintin (1990-05) -
Penicillin therapy of spontaneous streptococcal meningitis in pigs
McKellar, Quintin; Baxter, P.; Taylor, D.; Bogan, J. A. (1987-10)Oral prophylactic medication with either procaine penicillin G or a mixture of chlortetracycline, sulphadimidine and procaine penicillin G reduced the incidence of streptococcal meningitis in a herd of pigs with a high ... -
Pepsinogen types in worm-free sheep and in sheep infected with Ostertagia circumcincta and Haemonchus contortus
Mostofa, M.; McKellar, Quintin; Eckersall, P. D.; Gray, D. (1990)Pepsinogen isolated from the plasma of Dorset wethers with abomasal burdens of Ostertagia circumcincta was found to have the same proportions of three zymogen subtypes as that isolated from the plasma of Merino wethers ... -
Pharmaceutical quality of anthelmintics sold in Kenya
Monteiro, A.M.; Wanyangu, S.W.; Kariuki, D.P.; Bain, R.; Jackson, F.; McKellar, Quintin (1998-04)Nine anthelmintic products purchased in pharmacies and from agricultural merchants in Kenya were tested for pharmaceutical quality. The concentration of active drug was compared with the claim on the label, and the variability ... -
Pharmacodynamics and pharmacokinetics of carprofen in the horse.
Lees, P.; McKellar, Quintin; May, S.A.; Ludwig, B. (1994-05)The pharmacokinetics and pharmacodynamics of the nonsteroidal anti-inflammatory drug (NSAID) carprofen have been evaluated in 6 horses using a model of acute non-immune inflammation. Following intravenous administration ... -
Pharmacodynamics and pharmacokinetics of tolfenamicacid in ruminating calves: Evaluation in models of acute inflammation
Lees, P.; McKellar, Quintin; Foot, R.; Gettinby, G. (1998-05)Injections of mild irritants intradermally (carrageenan, zymosan and dextran) and intracaveally (carrageenan)in a tissue cage model of inflammation were used in studies of the pharmacodynamics and pharmacokinetics of ... -
The pharmacodynamics of ivermectin in sheep and cattle
Bogan, J. A.; McKellar, Quintin (1988-09)The concentrations of ivermectin in the gastrointestinal tract of sheep and cattle were determined after subcutaneous administration of ivermectin. Ivermectin was not detected (limit of detection 1 ng/ml) in abomasal and ... -
Pharmacodynamics of tolfenamic acid in dogs : Evaluation of dose response relationships
McKellar, Quintin; Lees, P.; Gettinby, G. (1994-03-03)Tolfenamic acid was administered to beagle dogs at 2, 4 and 8 mg/kg bodyweight i.m. and the concentration of drug in plasma and in inflamed (administered carrageenan) and non-inflamed subcutaneous tissue cage fluid was ... -
Pharmacodynamics, pharmacokinetics and faecal persistence of morantel in cattle and goats
McKellar, Quintin; Scott, E. W.; Baxter, P.; Anderson, L. A.; Bairden, K. (1993-03)Morantel could not be detected (<0.05 microgram/ml) in the plasma of cattle or goats following the oral administration of morantel tartrate at a dose rate of 10 mg/kg bodyweight. No morantel was detected in the milk of ... -
Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica
Sarasola, P.; Lees, P.; AliAbadi, F.S.; McKellar, Quintin; Donachie, W.; Marr, K.A.; Sunderland, S.J.; Rowan, T.G. (2002-09)The pharmacokinetics and pharmacodynamics of danofloxacin in calves with induced Mannheimia (Pasteurella) haemolytica pneumonia were evaluated. Calves received either saline as an intravenous (IV) bolus or danofloxacin ... -
Pharmacokinetic and pharmacodynamic studies on phenylbutazone and oxyphenbutazone in goats
Cheng, Z.; Welsh, E.; Nolan, A.; McKellar, Quintin (1997)Phenylbutazone was administered intravenously and orally to six goats as a single dose of 4.4 mg/kg and its disposition and bioavailability and the disposition of its active metabolite, oxyphenbutazone, in plasma were ... -
Pharmacokinetic disposition and faecal excretion of pyrantel embonate following oral administration in horses
Gokbulut, C.; Nolan, A.M.; McKellar, Quintin (2001-02) -
Pharmacokinetic features of the antiparasitic macrocyclic lactones
McKellar, Quintin; Gokbulut, Cengiz (2012-05)The macrocyclic lactones have pharmacokinetic properties which enhance their use against endo- and ectoparasites in animals and man. The most consistent physico-chemical feature of the group which contributes to their ... -
Pharmacokinetic studies of flunixin meglumine and phenylbutazone in plasma, exudate and transudate in sheep
Cheng, Z.; McKellar, Quintin; Nolan, A. (1998-08)Flunixin meglumine (FM, 1.1 mg/kg) and phenylbutazone (PBZ, 4.4 mg/kg) were administered intravenously (i.v.) as a single dose to eight sheep prepared with subcutaneous (s.c.) tissue-cages in which an acute inflammatory ... -
Pharmacokinetic, biochemical and tolerance studies on carprofen in the horse
McKellar, Quintin; Bogan, J. A.; von Fellenberg, R. L.; Ludwig, B.; Cawley, G. D. (1991-07)Carprofen, a non-steroidal anti-inflammatory drug (NSAID) was administered to three Thoroughbred geldings and three Shetland ponies to determine its plasma disposition and tolerance. The main pharmacokinetic characteristics ... -
Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine
McKellar, Quintin; Sanchez Bruni, S.F.; Jones, D.G. (2004-12)The rise in incidence of antimicrobial resistance, consumer demands and improved understanding of antimicrobial action has encouraged international agencies to review the use of antimicrobial drugs. More detailed understanding ... -
Pharmacokinetics and applications of ampicillin sodium as an intravenous infusion in the horse
Sarasola, P.; McKellar, Quintin (1993-03)A regime for administration of ampicillin sodium by continuous intravenous infusions to horses was designed. The aim was to achieve plasma ampicillin concentrations between 5 and 10 micrograms/ml over a 4-h period. A 2 ... -
Pharmacokinetics and clinical effects in dogs of a sustained-release formulation of theophylline
McKellar, Quintin (1993-08)Theophylline was administered orally in a sustained-release preparation at a dose rate of 20 mg/kg bodyweight to six beagle dogs. A mean (+/- se) maximum plasma concentration of 12.2 +/- 0.65 micrograms/ml was obtained ...