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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 121-140 of 435
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Effect of Nifedipine on the contractile responses of the isolated rat bladder
Zar, M. A.; Iravani, Mahmoud M.; Luheshi, G. N. (1990-04) -
Effect of NMDA receptor blockade on dopamine overflow in rat caudate putamen
Iravani, Mahmoud M.; Kruk, Z. L. (1992-12) -
The effect of nNOS inhibitors on toxin-induced cell death in dopaminergic cell lines depends on the extent of enzyme expression
Brzozowski, Monika J.; Alcantara, Susana Lopez; Iravani, Mahmoud M.; Rose, Sarah; Jenner, Peter (2011-08-02)Nitric oxide is linked with neurodegeneration in Parkinson's disease (PD) through the involvement of both inducible (iNOS) and neuronal nitric oxide synthase (nNOS). While nonselective NOS inhibitors are neuroprotective, ... -
The effect of prolonged CLP-induced sepsis on jejunal mesenteric afferent nerve activity in mice
Nullens, Sarah; Deiteren, Annemie; de Man, Joris; Keating, Christopher; Jiang, Wen; Grundy, D.; de Winter, Benedicte (2015-06) -
The effect of unilateral pallidotomy on motor disability, and L-dopa-induced dyskinesia in parkinsonian marmosets
Iravani, Mahmoud M.; Costa, S.; Jackson, M. J.; Al-Bargouthy, G.; Jenner, P. (2002) -
Effects of 6-Hydroxydopamine lesions in the ventral tegmental area or substantia-nigra on dopamine release in subregions of the rat striatum
Iravani, Mahmoud M.; Khan, S.; Michaeltitus, A.; Whelpton, R.; Kruk, Z. L. (1995-04) -
Effects of amphetamine on carrier-mediated and electrically stimulated dopamine release in slices of rat caudate-putamen abd nucleus-accumbens
Iravani, Mahmoud M.; Kruk, Z. L. (1995-03)The effects of (+)-amphetamine on carrier-mediated and electrically stimulated dopamine release were investigated using fast cyclic voltammetry in rat brain slices incorporating the nucleus accumbens, and in the caudate ... -
The effects of dopamine agonists and antagonists on the secretory responses in the salivary glands of the locust (Locusta migratoria)
Keating, Christopher; Orchard, Ian (2004-01)A study has been made on the effect of dopamine on salivary gland secretion rates from isolated locust salivary glands. Application of dopamine induced a concentration-dependent secretion with an IC50 of approximately 0.3 ... -
Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model
Saxton, Katie; Baines, Simon D.; Freeman, Jane; O'Connor, Rachael; Wilcox, M. H. (2009)The incidence of Clostridium difficile infection is increasing, with reports implicating fluoroquinolone use. A three-stage chemostat gut model was used to study the effects of three fluoroquinolones (ciprofloxacin, ... -
The effects of pallidotomy on motor function in MPTP-treated, L-DOPA primed common marmosets
Costa, S. S.; Iravani, Mahmoud M.; Jackson, M. J.; Jenner, P. (2004) -
Effects of piperacillin/tazobactam on Clostridium difficile growth and toxin production in a human gut model
Baines, Simon D.; Freeman, Jane; Wilcox, Mark H. (2005-06)Clostridium difficile infection (CDI) is a major cause of morbidity in the nosocomial environment. Antimicrobial agents such as the third-generation cephalosporins, lincosamides and aminopenicillins are well known for their ... -
Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains
Fawley, Warren N; Underwood, Sarah; Freeman, Jane; Baines, Simon D.; Saxton, Katie; Stephenson, Keith; Owens, Robert C.; Wilcox, M. H. (2007)To compare the effects of hospital cleaning agents and germicides on the survival of epidemic Clostridium difficile strains. -
Efficacy of novel antimicrobial agent SMT-19969 (SMT) against simulated Clostridium difficile infection in an in vitro human gut model
Baines, Simon D.; Freeman, J.; Huscroft, Grace S.; Todhunter, Sharie L.; Wilcox, M. H.; Vickers, R. (2011-09)Background: C. difficile infection (CDI) is the leading cause of nosocomial diarrhoea. Current CDI therapy is limited to metronidazole (M) or vancomycin. Recent evidence suggests reduced M efficacy and emergence of reduced ... -
The eggshell membrane : A potential biomaterial for corneal wound healing
Mensah, Rosemond A; Jo, Seung Bin; Kim, Hoon; Park, Sung-Min; Patel, Kapil D; Cho, Kyong J; Cook, Michael T; Kirton, Stewart B; Hutter, Victoria; Sidney, Laura E; Alves-Lima, Decio; Lin, Hungyen; Lee, Jung-Hwan; Kim, Hae-Won; Chau, David Ys (2021-06-18)The eggshell membrane (ESM) is an abundant resource with innate complex structure and composition provided by nature. With at least 60 million tonnes of hen eggs produced globally per annum, utilisation of this waste ... -
Electrochemical detection of dopamine and nitric-oxide in-vitro and in rat corpus striatum : a study using fast cyclic voltammetry with a sinusoidal drive wave-form
Iravani, Mahmoud M.; Millar, J.; Kruk, Z. L. (UNIV BORDEAUX I, LAB NEUROSCI COMPORTEMENTALES & COGNITIVES, 1994) -
Electrostatic determinants of the ion channel control of the nicotinic acetylcholine receptor of Torpedo californica
Kukol, A.; Neumann, E. (1998)The patch clamp K+-conductance G of the nicotinic acetylcholine receptor (AcChoR) dimer (M(r)approximate to 590 000) of Torpedo californica, reconstituted in lipid vesicles, icles, which decreases with increasing Cain the ... -
Elemental fingerprinting of Hypericum perforatum (St John's Wort) herb and preparations using ICP-OES and chemometrics
Owen, Jade D.; Kirton, Stewart B.; Evans, Sara J.; Stair, Jacqueline L. (2016-06-05)St. John's wort (SJW) (Hypericum perforatum) is a herbal remedy commonly used to treat mild depression. The elemental profiles of 54 samples (i.e., dry herbs, tablets and capsules) were evaluated by monitoring 25 elements ... -
Elemental Profile of Hypericum perforatum (St John's Wort) Preparations Using Icp-Oes
Owen, Jade D.; Evans, Sara J.; Stair, Jacqueline L. (2010-10) -
Emergence and identification of new products of designer drug products from the internet
Assi, Sulaf; Fergus, Suzanne; Stair, Jacqueline; Corazza, Ornella; Schifano, Fabrizio (2011)Designer drugs represent a rapidly expanding phenomenon particularly facilitated by their Internet availability. These drugs are continuously emerging as analogues of controlled substances (amfetamine, aminoindane, cathinone, ... -
Emergence of reduced susceptibility to metronidazole in Clostridium difficile
Baines, Simon D.; O'Connor, Rachael; Freeman, Jane; Fawley, Warren N; Harmanus, Celine; Mastrantonio, Paola; Kuijper, Ed J.; Wilcox, M. H. (2008)Antimicrobial treatment for Clostridium difficile infection (CDI) has typically been metronidazole, although reports have questioned the efficacy of this option. We screened recently isolated C. difficile (2005-06) for ...