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Pharmacokinetics and clinical efficacy of a cinchophen and prednisolone combination in the dog
McKellar, Quintin; Pearson, T.; Galbraith, E.A.; Boyle, J.; Bell, G. (1991-02)The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) were assessed in the dog. Cinchophen administered at a dose rate of 12-5 mg/kg intravenously had a volume of distribution (Vd area) of ... -
Pharmacokinetics and pharmacodynamics of phenylbutazone and oxyphenbutazone in the donkey
Cheng, Z.; McKellar, Quintin; Nolan, A.; Lees, P. (1996-04) -
Pharmacokinetics and pharmacodynamics of piroxicam in dogs
Galbraith, E. A.; McKellar, Quintin (1991-06)Piroxicam was administered to beagle dogs intravenously and orally at a dose rate of 0.3 mg/kg bodyweight. It had an elimination half-life of 40.2 hours, a volume of distribution of 0.29 +/- 0.02 litres/kg and a body ... -
Pharmacokinetics and serum thromboxane inhibition of two non- steroidal anti-inflammatory drugs when administered to dogs by the intravenous or subcutaneous route
McKellar, Quintin; Galbraith, E.A.; Simmons, R. D. (1991-07) -
Pharmacokinetics and tissue disposition of danofloxacin in sheep
McKellar, Quintin; Gibson, I.F.; McCormack, R.Z. (1998-03)The plasma pharmacokinetics of danofloxacin administered at 1.25 mg kg(-1) body weight by the intravenous and intramuscular routes were determined in sheep. Tissue distribution was also determined following administration ... -
Pharmacokinetics and tolerance of florfenicol in Equidae
McKellar, Quintin; Varma, K.J. (1996-05)Florfenicol was administered to horses and ponies at a dose rate of 22 mg/kg bwt by i.v., i.m. and oral routes. Following i.v. administration it had an elimination half-life of 1.8 +/- 0.9 h, a body clearance of 0.4 +/- ... -
Pharmacokinetics of a porcine insulin zinc suspension in diabetic dogs
Graham, P.A.; Nash, A.S.; McKellar, Quintin (1997-10)Ten dogs with naturally occurring diabetes mellitus were injected with a highly purified porcine insulin zinc suspension at a dose according to their expected requirement. Plasma insulin and glucose concentrations were ... -
The pharmacokinetics of albendazole metabolites following administration of albendazole, albendazole sulfoxide and netobimin to one-month- and eight-month-old sheep
McKellar, Quintin; Coop, R. L.; Jackson, F. (1995-10)The principal metabolites detected in plasma of sheep following oral administration of albendazole (ABZ), albendazole sulfoxide (ABSO) and netobimin (NTB) each at 5.0 mg kg-1 body weight were ABSO and albendazole sulfone ... -
Pharmacokinetics of albendazole, albendazole sulfoxide and netobimin in goats
Benchaoui, H. A.; Scott, E. W.; McKellar, Quintin (1993-06) -
Pharmacokinetics of bacampicillin in equids
Sarasola, P.; McKellar, Quintin (1995)Bacampicillin hydrochloride is an ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract. It was administered intragastrically at a dose rate of 13.5 mg/kg of body weight to ... -
Pharmacokinetics of enrofloxacin and danofloxacin in plasma, inflammatory exudate, and bronchial secretions of calves following subcutaneous administration
McKellar, Quintin; Gibson, I.; Monteiro, A.; Bregante, M. (1999-08)Enrofloxacin (2.5 mg/kg of body weight) and danofloxacin (1.25 mg/kg) were administered subcutaneously to ruminating calves (n = 8) fitted with subcutaneous tissue cages. Concentrations of enrofloxacin, its metabolite ... -
Pharmacokinetics of fenbendazole in dogs
McKellar, Quintin; Harrison, P.; Galbraith, E. A.; Inglis, H. (1990)Fenbendazole was administered to dogs at a dose rate of 20 mg/kg body weight on a single occasion in gelatin capsules, on 5 consecutive days in feed, and on a single occasion as an alginate suspension. It was also administered ... -
The pharmacokinetics of flunixin meglumine in the sheep
Welsh, E. M.; McKellar, Quintin; Nolan, A. M. (1993-06)Flunixin meglumine was administered intravenously and intramuscularly in sheep and the pharmacokinetics of the drug studied. Plasma concentrations of flunixin were measured by high performance liquid chromatography. The ... -
Pharmacokinetics of halofuginone in cattle
Kinabo, L.D.B.; McKellar, Quintin (1989-11-01)The pharmacokinetics of the antitheilerial drug halofuginone were evaluated in healthy calves following oral administration, at a dose of 1·2 mg/kg body weight, repeated after 48 h. The maximum plasma concentration after ... -
Pharmacokinetics of ivermectin after oral or percutaneous administration to adult milking goats
Scott, E. W.; Kinabo, L. D.; McKellar, Quintin (1990-12) -
Pharmacokinetics of niclofolan in desert sheep
Ali, B. H.; el Sheikh, H. A.; McKellar, Quintin (1990-06) -
Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog
McKellar, Quintin; Pearson, T.; Bogan, J.A.; Gaibraith, E.A.; Lees, P.; Ludwig, B.; Tiberghien, M.P. (1990)The non-steroidal anti-inflammatory drug (NSAID) carprofen was administered to dogs as a mixed-micelle solution at a dose rate of 0–7 mg/kg intravenously, as a palatable paste at a dose rate of 0–7 mg/kg orally, and as an ... -
Pharmacological approaches towards rationalizing the use of endoparasitic drugs in small animals
Sanchez Bruni, S. F.; Jones, D. G.; McKellar, Quintin (2006)Parasitic diseases are an important health concern to small animal veterinarians worldwide, and their zoonotic potential is also of relevance to human medicine. The treatment and control of such conditions relies heavily ... -
Pharmacological assessment of netobimin as a potential anthelmintic for use in horses : Plasma disposition, faecal excretion and efficacy
Gokbulut, C.; Cirak, V. Y.; Senlik, B.; Yildirim, F.; McKellar, Quintin (2009)This study aimed to determine the plasma disposition and faecal excretion of netobimin (NTB) and its respective metabolites as well as the efficacy against strongyles in horses following oral administration. Netobimin (10 ... -
Pharmacologie des antiinflammatoires non steroidiens chez les bovins
McKellar, Quintin (1989)