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Pharmacology and therapeutics of non-steroidal anti-inflammatory drugs in the dog and cat 2 : Individual agents
McKellar, Quintin; May, S.A.; Lees, P. (1991)The general pharmacology of the non-steroidal anti-inflammatory drugs (NSAIDs) used in dogs and cats has been described in part 1 of this review (Lees and others 1991). This paper outlines the properties of the individual ... -
Pharmacology and therapeutics of nonsteroidal antiinflammatory drugs in the dog and cat 1 : General pharmacology
Lees, P.; May, S.A.; McKellar, Quintin (1991)The inflammatory process is described with particular reference to the cardinal signs, the microcir-culatory changes and the mediators and modulators of inflammation. Mediators and modulars comprise targets for therapeutic ... -
The pharmacology of flukicidal drugs
McKellar, Quintin; Kinabo, L. D. (1991-07) -
Plasma achiral and chiral pharmacokinetic behaviour of intravenous oxfendazole co-administered with piperonyl butoxide in sheep
Sanchez, S.; Jones, D.G.; Small, J.; McKellar, Quintin (2002-02)Co-administration of piperonyl butoxide (PB) potentiates fenbendazole (FBZ) in small ruminants. The resultant increase in bioavailability of FBZ and its metabolite oxfendazole (OFZ) has important implications for the ... -
Plasma and lung concentrations of oxytetracycline after its intramuscular administration in rats
Baxter, P.; McKellar, Quintin (1995-02) -
Plasma disposition and faecal excretion of oxfendazole, fenbendazole and albendazole following oral administration to donkeys
Gokbulut, C.; Akar, F.; McKellar, Quintin (2006)Fenbendazole (FBZ), oxfendazole (fenbendazole sulphoxide, FBZSO), and albendazole (ABZ) were administered orally to donkeys at 10 mg/kg bodyweight. Blood and faecal samples were collected from 1 to 120 h post-treatment. ... -
Plasma disposition of amikacin and interactions with gastrointestinal microflora in Equidae following intravenous and oral administration
Horspool, L. J.; Taylor, D. T.; McKellar, Quintin (1994-08)Amikacin was detectable (> 0.02 micrograms/ml) in plasma for 12 h in horses and donkeys and for 8 h in ponies following intravenous (i.v.) administration at a dose rate of 6 mg/kg bodyweight. The elimination half-life ... -
Plasma disposition, faecal excretion and in vitro metabolism of oxibendazole following oral administration in horses
Gokbulut, C.; Nolan, A.M.; McKellar, Quintin (2002-02)Oxibendazole (OBZ) was administered to eight horses at an oral dose of 10 mg kg(-1) bodyweight each. Parent OBZ could only be detected in plasma at the 0.5 and 1.0 hours post administration sampling times and the mean ... -
Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses
Gokbulut, C.; Nolan, A.M.; McKellar, Quinton (2001-09)The present study was carried out to investigate whether the pharmacokinetics of avermectins or a milbemycin could explain their known or predicted efficacy in the horse. The avermectins, ivermectin (IVM) and doramectin ... -
Plasma profiles of albendazole metabolites after administration of netobimin and albendazole in sheep : effects of parasitism and age
McKellar, Quintin; Jackson, F.; Coop, R. L.; Baggot, J. D. (1993)Netobimin and albendazole were administered to 3-month-old lambs with moderate infections of Nematodirus battus and to comparable parasite-naive lambs. Albendazole sulphoxide and albendazole sulphone concentrations were ... -
Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays
Brentnall, Claire; Cheng, Zhangrui; McKellar, Quintin; Lees, Peter (2012-12)Whole blood in vitro assays were used to determine the potency and selectivity of carprofen enantiomers for inhibition of the isoforms of cyclooxygenase (COX), COX-1 and COX-2, in the calf. S(+)-carprofen possessed ... -
Preliminary pharmacokinetic and pharmacodynamic studies on flunixin meglumine in donkeys
Cheng, Z.; McKellar, Quintin; Nolan, A.; Lees, P. (1996) -
The processes influencing the distribution of parasitic nematodes among naturally infected lambs
Stear, M.J.; Bairden, K.; Bishop, S. C.; Gettinby, G.; McKellar, Quintin; Park, M.; Strain, S.; WALLACE, D.S. (1998-08)The impact of mixed, nematode infection upon a group of animals will depend upon the number of nematodes present, how they are distributed among hosts and whether individuals that are heavily parasitized with one species ... -
Production of strains of the sheep parasite Ostertagia circumcincta by implantation of adult parasites into the abomasum of lambs
Scott, E. W.; McKellar, Quintin; Armour, J.; Bairden, K.; Bogan, J. A. (1988-07)The implantation of a single pair of adult parasites of Ostertagia circumcincta via the abomasa of four lambs resulted in the production of 19, 53, 393 and 425 viable larvae after faecal culture using faeces collected from ... -
Pros and cons of various intramammary preparations on the market
McKellar, Quintin (1993) -
Protein binding and in vitro serum thromboxane B2 inhibition by flunixin meglumine and meclofenamic acid in dog, goat and horse blood
Galbraith, E.A.; McKellar, QA (1996-07)lunixin was highly protein bound in the serum of dogs (92.2 per cent), gents (84.8 per cent) and horses (86.9 per cent). Meclofenamic acid was also highly protein bound, although there were larger differences between the ... -
Regulation of egg production, worm burden, worm length and worm fecundity by host responses in sheep infected with Ostertagia circumcincta
Stear, M. J.; Bishop, S. C.; Doligalska, M.; Duncan, J. L.; Holmes, P. H.; Irvine, J.; McCririe, L.; McKellar, Quintin; Sinski, E.; Murray, M. (1995-12)Following infection with Ostertagia circumcincta there was considerable variation in worm burdens, worm size and number of inhibited larvae even among sheep matched for age, sex, breed, farm of origin and history of parasite ... -
The relationship between the number and size of nematodes in the abomasum and the concentration of pepsinogen in ovine plasma
Stear, M.J.; Bairden, K.; McKellar, Quintin; Scott, I.; Strain, S.; Bishop, S.C. (1999-08)Six-month-old lambs that had been naturally infected with predominantlyTeladorsagia (Ostertagia) circumcinctawere tested for plasma pepsinogen concentrations because pepsinogen concentrations may reflect the extent of ... -
Relay bioavailability and toxicity of isometamidium residues : a model for human risk assessment
Kinabo, L. D.; Bogan, J. A.; McKellar, Quintin; Murray, M. (1989)The bioavailability and potential toxicity of the residues of the antitrypanosomal drug isometamidium (ISMM) in bovine tissues were investigated in male Sprague-Dawley rats. They were allowed to feed for 7 and 21 days on ... -
The repeatability of faecal egg counts, peripheral eosinophil counts, and plasma pepsinogen concentrations during deliberate infections with Ostertagia circumcincta
Stear, M.J.; Bishop, S.C.; Duncan, J.L.; McKellar, Quintin; Murray, M. (1995-03)Faecal egg counts, peripheral blood eosinophil counts and plasma pepsinogen concentrations were monitored during 2 successive, deliberate infections in 24 Scottish Blackface sheep. For all 3 techniques, the repeatability ...