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Fat Duckweed (Lemna gibba) might be much more widespread in Hertfordshire than previously thought
Mashanova, Alla; Espinosa Montiel, Javier; Barrero Sicilia, Cristina (2022-11-01) -
Flipped detection of psychoactive substances in complex mixtures using handheld Raman spectroscopy coupled to chemometrics
Calvo‐Castro, Jesus; Tchakounte, Steve N.; Guarino, Valentina; Ahmed, Adeel A.; Stair, Jacqueline L. (2022-05-23)New psychoactive substance (NPS) misuse represents a critical social and health problem. Herein, a novel flipped approach is presented for the detection of psychoactive substances in complex mixtures using portable Raman ... -
Fluorescence In Situ Hybridization on DNA Halo Preparations to Reveal Whole Chromosomes, Telomeres and Gene Loci
Godwin, Lauren S; Bridger, Joanna M; Foster, Helen (2021-03-04)The genome is associated with several structures inside cell nuclei, in order to regulate its activity and anchor it in specific locations. These structures are collectively known as the nucleoskeleton and include the ... -
The FMRFamide-like AF2 is present in the parasitic nematode Haemonchus contortus
Keating, Christopher; Holden-Dye, Lindy; Thorndyke, Michael C.; Williams, R.G.; Mallett, A.; Walker, Robert J. (1995-11)Peptides belonging to the FMRFamide family are widely distributed amongst invertebrates. We report here on the isolation of the FMRFamide neuropeptide AF2 (Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2) from the parasitic nematode ... -
FUNCTIONAL AND HISTOLOGICAL CHANGES IN RAT URINARY BLADDER FOLLOWING SHORT AND LONG TERM KETAMINE EXPOSURE
Gant, Alex; Fergus, Suzanne; Benham, Christopher; Lione, Lisa (2020-11-18)Introduction: Due partly to their dissociative properties, ketamine and related new psychoactive substances (NPS) are widely used as recreational drugs. This has led to the discovery of a link between the chronic use of ... -
Functional studies of specific imidazoline-2 receptor ligands
Nutt, D.J.; French, N.; Handley, S.; Hudson, A.; Husbands, S.; Jackson, H.; Jordan, S.; Lalies, M.D.; Lewis, J.; Lione, Lisa; Mallard, N.; Pratt, J. (1995-07) -
G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein product
Dhayan, Hansraj; Baydoun, A. R.; Kukol, A. (2014-10-15)G-quadruplexes are higher-order nucleic acid structures formed of square-planar arrangements of four guanine bases held together by Hoogsteen-type hydrogen bonds. Stacks of guanine tetrads are stabilised by intercalating ... -
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets
Iravani, Mahmoud M.; Costa, S.; Jackson, M. J.; Tel, Banu C.; Cannizzaro, C.; Pearce, R. K. B.; Jenner, P. (2001-02)Parkinson's disease (PD) is associated with a progressive loss of dopamine neurons in the substantia nigra and degeneration of dopaminergic terminals in the striatum. Although L-DOPA treatment provides the most effective ... -
Genetic differentiation between and within strains of the saw-toothed grain beetle, Oryzaephilus surinamensis (Coleoptera Silvanidae) at RAPD loci
Brown, R. J.; Malcolm, Colin; Mason, P. L.; Nichols, R. A. (1997-08)Nine strains of Oryzaephilus surinamensis have been kept in laboratory culture for periods ranging from 5 to 30 years (30-180 generations). Two RAPD primers provided sufficient information to separate the strains reliably ... -
Genetic Diversity of Mycobacterium tuberculosis Complex Strains Isolated from Patients with Pulmonary Tuberculosis in Anambra State, Nigeria
Uzoewulu, Gertrude; Lawson, Lovett; Nnanna, Ibeh; Rastogi, Nalin; Goyal, Madhu (2017-02-08)In this study, we analyzed Mycobacterium tuberculosis complex (MTC) genetic diversity in Anambra State, Nigeria based on spoligotyping followed by 5-loci exact tandem repeats (ETRs). Spoligotyping of 180 MTC strains isolated ... -
Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy
Walsh, Melissa B.; Janzen, Eva; Wingrove, Emily; Hosseinibarkooie, Seyyedmohsen; Rodriguez Muela, Natalia; Davidow, Lance; Dimitriadi, Maria; M. Norabuena, Erika; L Rubin, Lee; Wirth, Brunhilde; C. Hart, Anne (2020-09-16)Background: Understanding the genetic modifiers of neurodegenerative diseases can provide insight into the mechanisms underlying these disorders. Here, we examine the relationship between the motor neuron disease spinal ... -
Genome expansion of Arabis alpina linked with retrotransposition and reduced symmetric DNA methylation
Willing, Eva Maria; Rawat, Vimal; Mandáková, Terezie; Maumus, Florian; James, Geo Velikkakam; Nordström, Karl J.V.; Becker, Claude; Warthmann, Norman; Chica, Claudia; Szarzynska, Bogna; Zytnicki, Matthias; Albani, Maria C.; Kiefer, Christiane; Bergonzi, Sara; Castaings, Loren; Mateos, Julieta L.; Berns, Markus C.; Bujdoso, Nora; Piofczyk, Thomas; De Lorenzo, Laura; Barrero-Sicilia, Cristina; Mateos, Isabel; Piednoël, Mathieu; Hagmann, Jörg; Chen-Min-Tao, Romy; Iglesias-Fernández, Raquel; Schuster, Stephan C.; Alonso-Blanco, Carlos; Roudier, François; Carbonero, Pilar; Paz-Ares, Javier; Davis, Seth J.; Pecinka, Ales; Quesneville, Hadi; Colot, Vincent; Lysak, Martin A.; Weigel, Detlef; Coupland, George; Schneeberger, Korbinian (2015-02-02)Despite evolutionary conserved mechanisms to silence transposable element activity, there are drastic differences in the abundance of transposable elements even among closely related plant species. We conducted a de novo ... -
Genomic evidence for genes encoding leucine-rich repeat receptors linked to resistance against the eukaryotic extra- and intracellular Brassica napus pathogens Leptosphaeria maculans and Plasmodiophora brassicae
Stotz, Henrik; Pascoe, Harvey; Parham, Haddadi; Fitt, Bruce; Mashanova, Alla; Kukol, Andreas; Larkan, Nicholas; Hossein, Borhan (2018-06-01)Genes coding for nucleotide-binding leucine-rich repeat (LRR) receptors (NLRs) control resistance against intracellular (cell-penetrating) pathogens. However, evidence for a role of genes coding for proteins with LRR domains ... -
Ginger waste as a potential feedstock for a zero-waste ginger biorefinery: a review
Inthalaeng, Natthamon; Gao, Yang; Remón, Javier; Dugmore, Thomas I. J.; Ozel, Mustafa Z.; Sulaeman, Allyn; Matharu, Avtar S. (2022-12-16)Ginger consumption and its use in industrial applications such as essential oil and oleoresin extraction are growing globally. There will be increased volumes of ginger waste (rhizomes, stems and leaves) in the coming ... -
Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets
Costa, S.; Iravani, Mahmoud M.; Pearce, R. K. B.; Jenner, P. (2001-01-19)Glial cell line-derived neurotrophic factor (GDNF) has previously reduced motor deficits and preserved nigral dopamine neurones in rhesus monkeys with a unilateral MPTP-induced lesion of substantia nigra. We now report on ... -
Global Survey on Novel Psychoactive Substances & Effects of Ketamine in Lower Urinary tract
Elena Deligiani; Corkery, John; Lione, Lisa (2016-05-31)Global Survey on Novel Psychoactive Substances & Effects of Ketamine in Lower Urinary tract Introduction Over the last decade Novel Psychoactive Substances(NPS) and ketamine recreational use have been a substantial threat ... -
Guanidine derivatives as inhibitors of DDAH
Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Research in Mechanisms of Disease and Drug Discovery; Natural Product Chemistry and Drug Design; Department of Clinical, Pharmaceutical and Biological Science; Centre for Health Services and Clinical Research; School of Life and Medical Sciences; Rossiter, Sharon; Vallance, Patrick; Leiper, James; Selwood, David; Hartzoulakis, Basil (2009) -
The H3 receptor agonist immepip does not affect l-dopa-induced abnormal involuntary movements in 6-OHDA-lesioned rats
Papathanou, Maria; Jenner, Peter; Iravani, Mahmoud M.; Jackson, Michael; Stockwell, Kim; Strang, Isobel; Zeng, Bai-Yun; McCreary, Andrew; Rose, Sarah (2014-10-15)The treatment of dyskinesia in Parkinson׳s disease remains poor but H3 receptor agonists have been suggested as a novel pharmacological approach. We examined the effects of the H3 agonist, immepip, in 6-OHDA-lesioned rats ... -
Halogenated indole-3-acetic acids as oxidatively activated prodrugs with potential for targeted cancer therapy
Rossiter, S.; Folkes, L.K.; Wardman, P. (2002) -
Handheld Raman Spectroscopy in the First UK Home Office Licensed Pharmacist-Led Community Drug Checking Service
Mullin, Anthony; Scott, Mark; Vaccaro, Giorgia; Gittins, Rosalind; Ferla, Salvatore; Schifano, Fabrizio; Guirguis, Amira (2023-03-08)Across the world, the interest in point-of-care drug checking as a harm-reduction intervention is growing. This is an attempt to improve intelligence about current drug trends and reduce drug-related morbidity and mortality. ...