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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 181-200 of 435
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Harnessing the benefits of PPARβ/δ agonists
MacKenzie, Louise Susan; Lione, Lisa (2013-12)Lipid mediators have complex effects on the cell; one of the key transcriptional factors that moderate proliferation and inflammatory effects is PPARβ/δ. Following highly successful clinical trials using the PPARβ/δ agonists ... -
Heterogeneous effects of NMDA on dopamine release in the rat caudate-putamen
Iravani, Mahmoud M.; Kruk, Z. L. (1995-07) -
High content analysis of in vitro alveolar macrophage responses can provide mechanistic insight for inhaled product safety assessment
Hutter, Victoria; Hopper, Sarah; Skamarauskas, John; Hoffman, Ewelina (2023-02-28)Assessing the safety of inhaled substances in the alveolar region of the lung requires an understanding of how the respired material interacts with both physical and immunological barriers. Human alveolar-like macrophages ... -
High sporulation and overexpression of virulence factors in biofilms and reduced susceptibility to vancomycin and linezolid in recurrent Clostridium [Clostridioides] difficile infection isolates
Tijerina-Rodrıguez, Laura; Villarreal-Trevino, Licet; Baines, Simon; Morfin-Otero, Rayo; Camacho-Ortiz, Adrian; Flores-Trevino, Samantha; Maldonado-Garza, Hector Jesus; Garza-Gonzalez, Elvira; Rodriguez-Noriega, Eduardo; Rodrıguez-Noriega, Eduardo (2019-07-31)Clostridium [Clostridioides] difficile infection (CDI) is one of the leading causes of diarrhea associated with medical care worldwide, and up to 60% of patients with CDI can develop a recurrent infection (R-CDI). A ... -
Horseradish peroxidase-mediated gene therapy : choice of prodrugs in oxic and anoxic tumor conditions
Greco, O.; Rossiter, S.; Kanthou, C.; Folkes, L.K.; Wardman, P.; Tozer, G.M.; Dachs, G.U. (2001) -
How the amyloid-β peptide and membranes affect each other : An extensive simulation study
Poojari, Chetan; Kukol, A.; Strodel, Birgit (2013-02)The etiology of Alzheimer's disease is thought to be linked to interactions between amyloid-β (Aβ) and neural cell membranes, causing membrane disruption and increased ion conductance. The effects of Aβ on lipid behavior ... -
Hypoglycaemic and anti-hyperglycaemic activity of Tabernanthe iboga aqueous extract in fructose-fed Streptozotocin type 2 diabetic rats
Bading-Taika, Bayissi; Souza, Alain; Bourobou Bourobou, Henri-Paul; Lione, Lisa (2020-08-25)Root bark preparations of the Gabonese plant Tabernanthe iboga (T. iboga) has long been used in traditional medicine in Central and West African regions for the management of type 2 diabetes (T2D). This study is the first ... -
Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds
Anagani, Bhavani; Singh, Jagbir; Bassin, Jatinder; Besra, Gurdyal; Benham, Christopher; Reddy, Tummala Rama Krishna; Cox, Jonathan; Goyal, Madhu (2020-05-18)Objectives: The search for new TB drugs has become one of the great challenges for modern medicinal chemistry. An improvement in the outcomes of TB chemotherapy can be achieved by the development of new, shorter, cheap, ... -
Identification of new psychoactive substances (NPS) using handheld Raman Spectroscopy employing both 785 and 1064 nm laser sources
Guirguis, Amira; Girotto, Sarah; Berti, Benedetta; Stair, Jacqueline (2017-04-01)The chemical identification of new psychoactive substances (NPS) in the field is challenging due not only to the plethora of substances available, but also as a result of the chemical complexity of products and the chemical ... -
Identification of new psychoactive substances using Raman spectroscopy: handheld and computational approaches.
Guirguis, Amira; Kirton, Stewart; Zloh, Mire; Samaras, Eleftherios; Girotto, Sarah; Berti, Benedetta; Stair, Jacqueline (Research and Advances in Psychiatry, 2016-05)At this conference, I gave a presentation on the identification of new psychoactive substances using handheld Raman spectroscopy and chemometrics. -
Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells
Goh, Shan; Ngugi, Daniel; Lizundia, Regina; Hostettler, Isabel; Woods, Kerry; Ballingall, Keith; MacHugh, Niall D; Morrison, W Ivan; Weir, Willie; Shiels, Brian; Werling, Dirk (2016-09-09)As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata ... -
Immobilized peptides/amino acids on solid supports for metal remediation
Malachowski, L.; Stair, Jacqueline; Holcombe, James A. (2004-04)Recently, a significant amount of work has focused on metal binding by natural systems for various applications. This review will focus on the utility of amino acids, short peptides, and proteins that have been immobilized ... -
An immunohistochemical and stereological analysis of PSI-induced nigral neuronal degeneration in the rat
Bukhatwa, Salma; Iravani, Mahmoud M.; Zeng, Bai-Yun; Cooper, Jonathan D.; Rose, Sarah; Jenner, Peter (2009-04)Systemic administration of the proteasomal inhibitor I (PSI) to rats was reported to cause progressive nigral dopaminergic neuronal loss but this is disputed. A major controversy centres over the use of manual counting of ... -
Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6
Kirton, S.B.; Sutcliffe, M.J.; Kemp, C.A.; Tomkinson, N.P.; St-Gallay, S. (2002-11-01)Cytochrome P450 2D6 (CYP2D6) metabolizes approximately one third of the drugs in current clinical use. To gain insight into its structure and function, we have produced four different sets of comparative models of 2D6: one ... -
The Impact of Semicarbazide Sensitive Amine Oxidase Activity on Rat Aortic Vascular Smooth Muscle Cells
Manasieva, Vesna; Thakur, Shori; Lione, Lisa A.; Baydoun, Anwar R.; Skamarauskas, John (2023-03-03)Semicarbazide-sensitive amine oxidase (SSAO) is both a soluble- and membrane-bound transmembrane protein expressed in the vascular endothelial and in smooth muscle cells. In vascular endothelial cells, SSAO contributes to ... -
Impact of the UK Psychoactive Substances Act on awareness, use, experiences and knowledge of potential associated health risks of Novel Psychoactive Substances
Deligianni, Elena; Daniel, Omari-Jordan; Corkery, John; Schifano, Fabrizio; Lione, Lisa (2020-03-01)Aims: The risk of potential harms prompted the UK government to introduce the Psychoactive Substances Act in 2016. The aim of the present study was to evaluate the impact and effectiveness of this new legislation on patterns ... -
In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\increased motor disability
Iravani, Mahmoud M.; Tayarani-Binazir, Kayhan; Chu, Wing B.; Jackson, Michael J.; Jenner, Peter (2006-12)5-Hydroxytryptamine 1a (5-HT1a) receptor agonists, such as sarizotan and tandospirone, are reported to reduce levodopainduced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaques and in ... -
In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma
Orton, Sophie; Karkia, Rebecca; Mustafov, Denis; Gharanei, Seley; Braoudaki, Maria; Filipe, Alice; Panfilov, Suzana; Saravi, Sayeh; Khan, Nabeel; Kyrou, Ioannis; Karteris, Emmanouil; Chatterjee, Jayanta; Randeva, Harpal S. (2024-01-30)Background: Protein Tyrosine Phosphatase Receptor Type D (PTPRD) is involved in the regulation of cell growth, differentiation, and oncogenic transformation, as well as in brain development. PTPRD also mediates the effects ... -
In silico investigation of novel compounds as inhibitors of Acetylcholinesterase enzyme for the treatment of Alzheimer’s diseases
Adebambo, Kassim; Ojoh, Oghenekevwe (Claudia) (2024-02-08)Alzheimer’s disease (AD) is a “progressive, neurodegenerative disease that occurs when nerve cells in the brain die.” There are only 4 drugs approved by the United States Food and Drug Administration (FDA). Three (donepezil, ... -
In Silico Investigations into the Selectivity of Psychoactive and New Psychoactive Substances in Monoamine Transporters
Kirton, Stewart; Botha, Michelle (2022-11-01)New psychoactive substances (NPS) are a group of compounds that mimic the effects of illicit substances. A range of NPS have been shown to interact with the three main classes of monoamine transporters (DAT, NET, and SERT) ...