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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
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Antimicrobial resistance and reduced susceptibility in Clostridium difficile: potential consequences for induction, treatment, and recurrence of C. difficile infection.
Baines, Simon D.; Wilcox, M. H. (2015-07-10)Clostridium difficile infection (CDI) remains a substantial burden on healthcare systems and is likely to remain so given our reliance on antimicrobial therapies to treat bacterial infections, especially in an aging ... -
Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect
Nikravesh, Abbas; Dryselius, Rikard; Faridani, Omid R; Goh, Shan; Sadeghizadeh, Majid; Behmanesh, Mehrdad; Ganyu, Anita; Klok, Erik Jan; Zain, Rula; Good, Liam (2007-08-01)Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier ... -
Antiviral Drug Target Identification and Ligand Discovery
Patel, Hershna; Sengupta, Dipankar (Humana Press, 2023-09-08)This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we explain how the structure for a potential viral protein target can be obtained and then ... -
Arylalkylpiperazines for use as neuroprotective agents : Arlyalkylpiperazines and neuroprotection
Basic and Clinical Science Unit; School of Life and Medical Sciences; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Iravani, Mahmoud (2016-04-07)A compound of the general formula A or a or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is selected from the group consisting of: C1-C12-alkyl, C3-C12-cycloalkyl, C6- C10-aryl, and C5-C7-heteroaryl; ... -
The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1
Iglesias-Fernández, Raquel; Wozny, Dorothee; Iriondo-De Hond, Maite; Oñate-Sánchez, Luis; Carbonero, Pilar; Barrero-Sicilia, Cristina (2014-05-01)Protein hydrolysis plays an important role during seed germination and post-germination seedling establishment. In Arabidopsis thaliana, cathepsin B-like proteases are encoded by a gene family of three members, but only ... -
Autophagy in spinal muscular atrophy: from pathogenic mechanisms to therapeutic approaches
Rashid, Saman; Dimitriadi, Maria (2024-01-08)Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by the depletion of the ubiquitously expressed survival motor neuron (SMN) protein. While the genetic cause of SMA has been well documented, the ... -
Banning psychoactive substances is not enough, we need education too.
Lione, Lisa (2016-06-06) -
The BdGAMYB protein from Brachypodium distachyon interacts with BdDOF24 and regulates transcription of the BdCathB gene upon seed germination
González-Calle, Virginia; Iglesias-Fernández, Raquel; Carbonero, Pilar; Barrero-Sicilia, Cristina (2014-09-30)Main conclusion: BdDOF24 interacting with BdGAMYB regulates the BdCathB gene upon germination. During barley seed germination, hydrolytic enzymes (α-amylases, proteases, etc.) synthesized in the aleurone layer in response ... -
Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets
Dass, B.; Iravani, Mahmoud M.; Jackson, M. J.; Engber, T. M.; Galdes, A.; Jenner, P. (2002)Sonic hedgehog (SHH) has trophic actions on dopaminergic cell cultures and protects them from MPP+ toxicity but its in vivo actions have not been explored. We now investigate the effects of unilateral supranigral administration ... -
The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions
Zloh, Mire; Kirton, Stewart (2018-02-01)The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative platforms. The evolution of computational ... -
Benzodiazepine Boom: Tracking Etizolam, Pyrazolam, and Flubromazepam from Pre-UK Psychoactive Act 2016 to Present Using Analytical and Social Listening Techniques
Mullin, Anthony; Scott, Mark; Vaccaro, Giorgia; Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Corkery, John M; Stair, Jacqueline L; Schifano, Fabrizio; Guirguis, Amira (2024-01-12)Introduction: The designer benzodiazepine (DBZD) market continues to expand whilst evading regulatory controls. The widespread adoption of social media by pro-drug use communities encourages positive discussions around ... -
Bicyclic 6-6 Systems: Pteridines
Rossiter, Sharon; Ostovar, Mehrnoosh (Elsevier, 2022)This article describes the literature on pteridines, covering the period from 2008 to 2020. The physical properties and reactions include photochemistry, substitution at ring nitrogens, nucleophilic substitution at ring ... -
Bioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignancies
Braoudaki, Maria; Koutsouris, Dimitrios-Dionysios; Kouris, Ioannis; Paidi, Anna; Koutsouri, Georgia; George Lambrou, I (Institute of Electrical and Electronics Engineers (IEEE), 2018-10-29)Pediatric Central Nervous System (CNS) neoplasms are the second most prevalent tumors of childhood. Further on, prognosis of this type of neoplasms still remain poor and the comprehension of the etiology and pathogenesis ... -
Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum( iv ) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple negative breast cancer cells †
Sedky, Nada K.; Braoudaki, Maria; Mahdy, Noha Khalil; Amin, Kenzy; Fawzy, Iten M.; Efthimiadou, Eleni K.; Youness, Rana A.; Fahmy, Sherif Ashraf (2023-09-15)Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were optimized using the Box–Behnken design (BBD). The ... -
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins
Anderson, Edward N.; Corkins, Mark E.; Li, Jia Cheng; Singh, Komudi; Parsons, Sadé; Tucey, Tim M.; Sorkaç, Altar; Huang, Huiyan; Dimitriadi, Maria; Sinclair, David A.; Hart, Anne C. (2016-03-01)Moderate stress can increase lifespan by hormesis, a beneficial low-level induction of stress response pathways. 5'-fluorodeoxyuridine (FUdR) is commonly used to sterilize Caenorhabditis elegans in aging experiments. ... -
C2 by-pass: Cross-talk between the complement classical and alternative pathways
Laich, A; Patel, H; Zarantonello, A; Sim, R B; Inal, J M (2022-05-31)Several disorders associated with the total or partial absence of components of the human complement system are known. Deficiencies of classical pathway (CP) components are generally linked to systemic lupus erythematosus ... -
Cannabinoid signalling in TNF-alpha induced IL-8 release
Mormina, M. E.; Thakur, S.; Molleman, A.; Whelan, C.J.; Baydoun, A. R. (2006) -
A cellulose-based bioassay for the colorimetric detection of pathogen DNA
Saikrishnan, Deepika; Goyal, Madhu; Rossiter, Sharon; Kukol, A. (2014-12-01)Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen ... -
The changing epidemiology of Clostridium difficile infections
Freeman, J.; Bauer, M. P.; Baines, Simon D.; Corver, J.; Fawley, W. N.; Goorhuis, B.; Kuijper, E. J.; Wilcox, M. H. (2010)The epidemiology of Clostridium difficile infection (CDI) has changed dramatically during this millennium. Infection rates have increased markedly in most countries with detailed surveillance data. There have been clear ... -
Characterisation and localisation of [3H]2-(2-benzofuranyl)-2-imidazoline binding in rat brain : a selective ligand for imidazoline I2 receptors
Lione, Lisa; Nutt, D.J.; Hudson, A.L. (1998-07)