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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 221-240 of 435
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An international survey on the awareness, use, preference and health perception of Novel Psychoactive Substances (NPS)
Deligianni, Elena; Corkery, John; Schifano, Fabrizio; Lione, Lisa (2017-05-08)ObjectiveThis survey investigated the level of public awareness, preference and motivation of NPS use as well as knowledge of potential associated health risks.Methods A Bristol Online Survey was advertised through social ... -
Intestinal Secretory and Absorptive Function in the Trichinella spiralis mouse model of Post-Infective Gut Dysfunction : role of bile acids
Kalia, N.; Hardcastle, J.; Grassi, Laura; Keating, Christopher; Pelegrin, Pablo; Bardhan, K.D.; Grundy, David (2008)Objective: Observations showing that bile acid malabsorption is frequent in irritable bowel syndrome (IBS) suggest that alterations in bile acid-induced secretion and absorption could contribute to IBS-associated diarrhoea. ... -
Investigation of the mode of action of nematode neuropeptides
Keating, Christopher; Holden-Dye, Lindy; Walker, Robert J. (1996-03)The neuropeptide AF2 has a complex set of actions on the dorsal muscle strip of Ascaris suum, including a potentiation of the acetylcholine-stimulated muscle contraction. Caffeine at 100 μm and 5 mm inhibited this potentiation, ... -
Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration
Iravani, Mahmoud M.; Kashefi, K.; Mander, P.; Rose, S.; Jenner, P. (2002-03)The loss of dopaminergic neurotics in the substantia nigra with Parkinson's disease may result from inflammation-induced proliferation of microglia and reactive macrophages expressing inducible nitric oxide synthase (iNOS). ... -
Ion channels - Analysis and simulation embedded in a flexible environment
Kukol, A. (1998-03-25)A collection of programs for ion-channel analysis is described. The package contains all standard routines for single-channel analysis and some routines for fluctuation analysis. Additionally, advanced algorithms for ... -
Ketamine supresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression
Kantor, Sandor; Lanigan, Michael; Giggins, Lauren; Lione, Lisa; Magomedova, Lilia; de Lannoy, Inés; Upton, Neil; Duxon, Mark (2023-07-09)Wistar–Kyoto (WKY) rats exhibit depression-like characteristics and decreased sensitivity to monoamine-based antidepressants, making them a suitable model of treatment-resistant depression (TRD). Ketamine has emerged ... -
L30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes
Himes, Ryan D.; Smolin, Nikolai; Kukol, Andreas; Bossuyit, Julie; Beers, Donald M.; Robia, Seth L. (2016-11-08)To determine if mutations introduced into phospholemman (PLM) could increase the level of PLM–Na,K-ATPase (NKA) binding, we performed scanning mutagenesis of the transmembrane domain of PLM and measured Förster resonance ... -
Label free electrical detection of DNA hybridisation for the example of influenza virus gene sequences
Kukol, A.; Li, P.; Estrela, P.; Ko-Ferrigno, P.; Migliorato, P. (2008)Microarrays based on DNA–DNA hybridization are potentially useful for detecting and subtyping viruses but require fluorescence labeling and imaging equipment. We investigated a label-free electrical detection system using ... -
Laboratory rearing of mosquitos (Anopheles arabiensis): impact on genetic variability and implications for Sterile Insect Technique (SIT) based mosquito control in northern Sudan
Azrag, Rasha S.; Ibrahim, K. M.; Malcolm, Colin A.; El Rayah, E.; El Sayed, Badria (2016-08-25)The population genetic makeup of the 13th generation of a laboratory colony of Anopheles arabiensis mosquitos at 11 microsatellite loci was compared to that of the field population from which the colony was founded. Major ... -
A laboratory-based evaluation of tube blocking and microbial risks associated with one blended enteral feed recipe
Madden, Angela; Baines, Simon; Bothwell, Simone; Chen, Elise; Goh, Shan; Jerome, Lee; Sommariva-Nagle, Cara; Szychta, Malgorzata (2019-10-01)Background: Concerns associated with blended enteral feeds include the risk of blocked tubes and microbial contamination, although the available evidence is limited. The present laboratory-based investigation aimed to ... -
Large-scale analysis of influenza A virus nucleoprotein sequence conservation reveals potential drug-target sites
Kukol, A.; Hughes, David (2014-04-30)The nucleoprotein (NP) of the influenza A virus encapsidates the viral RNA and participates in the infectious life cycle of the virus. The aims of this study were to find the degree of conservation of NP among all virus ... -
Large-scale analysis of Influenza A virus sequences reveals potential drug-target sites of non-structural proteins
Darapaneni, V.; Prabhakar, V.; Kukol, A. (2009-10)The non-structural protein 1 (NS1) of the influenza A virus and the NS2 protein, which is also known as nuclear export protein, play important roles in the infectious life cycle of the virus. The objective of this study ... -
Layered Polyelectrolyte Films as Selective, Ultrathin Barriers for Anion Transport
Stair, Jacqueline (2000-06-23)Synthesis of high-flux composite membranes requires methods for deposition of ultrathin, defect-free films on highly permeable supports. Layer-by-layer deposition of polyelectrolytes on porous alumina (0.02 µm pore diameter) ... -
Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration
Doherty, Gayle; Holiday, Alison; Malekizadeh, Yasaman; Manolescu, Cosmin; Duncan, Stephen; Flewitt, Iona; Hamilton, Kirsty; MacLeod, Beth; Ainge, James, A; Harvey, Jenni (2022-11-29)Key pathological features of Alzheimer's disease (AD) include build-up of amyloid β (Aβ), which promotes synaptic abnormalities and ultimately leads to neuronal cell death. Metabolic dysfunction is known to influence the ... -
Lipid membranes for membrane proteins
Kukol, A. (Springer Nature, 2015-01-01) -
Lipid models for united-atom molecular dynamics simulations of proteins
Kukol, A. (2009)United-atom force fields for molecular dynamics (MD) simulations provide a higher computational efficiency, especially in lipid membrane simulations, with little sacrifice in accuracy, when compared to all-atom force fields. ... -
Lipid remodelling: unravelling the response to cold stress in Arabidopsis and its extremophile relative Eutrema salsugineum
Barrero Sicilia, Cristina; Silvestre, Susana; Michaelson, Louise V.; Haslam, Richard P. (2017-10-01)Environmental constraints limit the geographic distribution of many economically important crops. Cold stress is an important abiotic stress that affects plant growth and development, resulting in loss of vigour and surface ... -
Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor.
Iravani, Mahmoud M.; Sadeghian, Mona; Leung, Clement C. M.; Jenner, Peter; Rose, Sarah (2012-02-29)Reactive gliosis and inflammatory change is a key component of nigral dopaminergic cell death in Parkinson's disease (PD). Astrocyte derived glial cell line-derived neurotrophic factor (GDNF) promotes the survival and ... -
Loss of locus coeruleus noradrenergic neurons alters the inflammatory response to LPS in substantia nigra but does not affect nigral cell loss
Iravani, Mahmoud M.; Sadeghian, Mona; Rose, Sarah; Jenner, Peter (2014-12-01)In Parkinson's disease (PD), destruction of noradrenergic neurons in the locus coeruleus (LC) may precede damage to nigral cells and subsequently exaggerate dopaminergic cell loss. We examine if destruction of the locus ... -
Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson's disease
Modo, Michel; Crum, William R; Gerwig, Madeline; Vernon, Anthony C; Patel, Priya; Jackson, Michael J; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud M (2017-07-24)Parkinson's disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is ...