- UHRA Home
- Browsing by Author
Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 241-260 of 435
-
Mannans and endo-β-mannanases (MAN) in Brachypodium distachyon : Expression profiling and possible role of the BdMAN genes during coleorhiza-limited seed germination
González-Calle, Virginia; Barrero-Sicilia, Cristina; Carbonero, Pilar; Iglesias-Fernández, Raquel (2015-07-01)Immunolocalization of mannans in the seeds of Brachypodium distachyon reveals the presence of these polysaccharides in the root embryo and in the coleorhiza in the early stages of germination (12h), decreasing thereafter ... -
Mapping the energy surface of transmembrane helix-helix interactions
Torres, J.; Kukol, A.; Arkin, I.T. (2001-11)Transmembrane helices are no longer believed to be just hydrophobic segments that exist solely to anchor proteins to a lipid bilayer, but rather they appear to have the capacity to specify function and structure. Specific ... -
Measurement of toxin production by Clostridium difficile
Freeman, Jane; Fawley, Warren; Baines, Simon D.; Wilcox, Mark (2006-01) -
Mechanisms contributing to visceral hypersensitivity : focus on splanchnic afferent nerve signalling
Deiteren, Annemie; de Man, Joris; Keating, Christopher; Jiang, Wen; de Schepper, Heiko; Pelckmans, Paul; Francque, Sven; de Winter, Benedicte (2015-11-19)Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated ... -
Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation
Iravani, Mahmoud M.; Jenner, Peter (2011-12)A significant proportion of patients with Parkinson's disease (PD) receiving dopamine replacement therapy in the form of levodopa develop dyskinesia that becomes a major complicating factor in treatment. Dyskinesia can ... -
Mecillinam : a low-risk antimicrobial agent for induction of Clostridium difficile infection in an in vitro human gut model
Baines, Simon D.; O'Connor, Rachael; Huscroft, Grace; Saxton, Katie; Freeman, Jane; Wilcox, Mark H (2009) -
Membrane vesicles of Clostridioides difficile and other Clostridial species
Goh, Shan; Inal, Jameel (Springer Nature, 2024-01-05)Membrane vesicles are secreted by growing bacterial cells and are important components of the bacterial secretome, with a role in delivering effector molecules that ultimately enable bacterial survival. Membrane vesicles ... -
Mephedrone (4-methylmethcathinone; 'meow meow') : chemical, pharmacological and clinical issues
Schifano, Fabrizio; Albanese, Antonio; Fergus, Suzanne; Stair, Jacqueline; Deluca, Paolo; Corazza, Ornella; Davey, Zoe; Corkery, John; Siemann, Holger; Scherbaum, Norbert; Farre', Magi'; Torrens, Marta; Demetrovics, Zsolt; Ghodse, A. Hamid; ReDNet Res Grp, Psychonaut Web Mapping (2011)Recently, those substances deriving from the active ingredient of the Khat plant, cathinone, have been rising in popularity. Indeed, 4-methylmethcathinone (mephedrone; 'meow meow' and others) has been seen by some as a ... -
Metabolism of AF1 (KNEFIRF-NH2) in the nematode, Ascaris suum, by aminopeptidases, endopeptidase and deaminase enzymes
Sajid, Mohammed; Keating, Christopher; Holden-Dye, Lindy; Harrow, Ian D.; Isaac, R.Elwyn (1996-01)We have studied the metabolism and inactivation of AF1 (KNEFIRF-NH2) by membranes prepared from the locomotory muscle of Ascaris suum. FIRF-NH2, NEFIRF-NH2 and KNEFIRF were identified as three primary degradation products, ... -
Metal binding characterization and conformational studies using Raman microscopy of resin-bound poly(aspartic acid)
Stair, Jacqueline L.; Holcombe, James A. (2007-03-01)The metal binding capacities, conditional stability constants, and secondary structure of immobilized polyaspartic acid (PLAsp) (n = 6, 20, and 30) on TentaGel resin were determined when binding Mg2+, Co2+, Cd2+, and Ni2+. ... -
Metal remediation and preconcentration using immobilized short-chain peptides composed of aspartic acid and cysteine
Holcombe, James A.; Stair, Jacqueline (2005-08)Short-chain peptides (two and seven residues) consisting of a glycine (Gly) attachment group and various combinations of cysteine (Cys) and/or aspartic acid (Asp) were synthesized by Fmoc solid phase peptide synthesis ... -
Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion
Patel, Pryank; Clarke, Christopher; Barraclough, Dong Liu; Jowitt, Thomas Adam; Rudland, Philip Spencer; Barraclough, Roger; Lian, Lu-Yun (2013-03-11)Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion. These normal intracellular and abnormal ... -
Method Development for the Determination of Elements in Hypericum perforatum L. (St John’s wort) Herb and Preparations using ICP-OES and Microwave Digestion
Owen, Jade; Evans, Sara; Guirguis, Amira; Kellett, Kathryn; Stair, Jacqueline (2017-05-31)Objectives: A method was developed to analyze St John's wort (Hypericum perforatum L.) herb and preparations using inductively coupled plasma-optical emission spectroscopy (ICP-OES) to determine the quantity of 11 elements ... -
Methyl-group effect on the proton affinity of methylated acetophenons studied by two mass-spectrometric techniques
Kukol, A.; Strehle, F.; Thielking, G.; Grutzmacher, H. F. (1993-10)The proton affinities (PA) of all isomeric dimethylacetophenones were determined using the 'kinetic method' with a tandem mass spectrometer and by measurements of the proton transfer equilibrium in the gas phase by Fourier ... -
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies
Shamsaldeen, Yousif; MacKenzie, Louise; Lione, Lisa; Benham, Christopher (2016-05)Background: Diabetes mellitus (DM) is a pandemic metabolic disease characterized by a chronically elevated blood glucose concentration (hyperglycemia) due to insulin dysfunction. Approximately 50% of diabetics show diabetes ... -
MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors.
Braoudaki, Maria; Lambrou; Papadodima; Stefanaki; Prodromou; Kanavakis (2016-01-30)Among noncoding RNAs, microRNAs (miRNAs) have been most extensively studied, and their biology has repeatedly been proven critical for central nervous system pathological conditions. The diagnostic value of several miRNAs ... -
MicroRNAs Regulate Ca 2+ Homeostasis in Murine Embryonic Stem Cells
Reid, Kimberley M.; Sanchez-Nieto, Juan Miguel; Terrasse, Sandra; Faccenda, Danilo; Pernaute, Barbara; Campanella, Michelangelo; Rodriguez, Tristan A.; Cobb, Bradley S. (2023-07-28)MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics ... -
Mitochondrial DNA, a Powerful Tool to Decipher Ancient Human Civilization from Domestication to Music, and to Uncover Historical Murder Cases
Merheb, Maxime; Matar, Rachel; Hodeify, Rawad; Siddiqui, Shoib Sarwar; Vazhappilly, Cijo George; Marton, John; Azharuddin, Syed; Al Zouabi, Hussain (2019-05-09)Mitochondria are unique organelles carrying their own genetic material, independent from that in the nucleus. This review will discuss the nature of mitochondrial DNA (mtDNA) and its levels in the cell, which are the key ... -
Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review
Bassin, Jatinder; Dimitriadi, Maria; Cook, Michael T.; Abelha, Thais Fedatto; Calvo-Castro, Jesus (2022-09-19)The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria ... -
Mixed infection by Clostridium difficile in an in vitro model of the human gut
Baines, Simon D.; Crowther, Grace S.; Todhunter, Sharie L.; Freeman, Jane; Chilton, Caroline H.; Fawley, Warren N.; Wilcox, Mark H. (2013)OBJECTIVES: Clostridium difficile infection (CDI) is still a major clinical challenge. Previous studies have demonstrated multiple distinct C. difficile strains in the faeces of patients with CDI; yet whether true mixed ...