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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 321-340 of 435
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Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation
Alsawaf, Seba; Alnuaimi, Fatema; Afzal, Saba; Thomas, Rinku Mariam; Chelakkot, Ayshwarya Lakshmi; Ramadan, Wafaa S.; Hodeify, Rawad; Matar, Rachel; Merheb, Maxime; Siddiqui, Shoib Sarwar; Vazhappilly, Cijo George (2022-11-26)Simple Summary: Increased stress is often observed in patients with kidney diseases, contributing to renal injury progression. Flavonoids are naturally occurring plant compounds with known health benefits, including ... -
Poly(N-isopropyl acrylamide) – poly(ethylene glycol) – poly(N-isopropyl acrylamide) as a thermoreversible gelator for topical administration
Haddow, Peter; McAuley, William; Kirton, Stewart; Cook, Michael T. (2020-05-06)Poly(N-isopropyl acrylamide) – block– poly(ethylene glycol) – block– poly(N-isopropyl acrylamide) is known to exhibit a thermally-induced solution-to-gel transition in water, which may be exploited for biomedical applications. ... -
Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Material
Haddow, Peter J.; da Silva, Marcelo A.; Kaldybekov, Daulet B.; Dreiss, Cecile A.; Hoffman, Ewelina; Hutter, Victoria; Khutoryanskiy, Vitaliy V.; Kirton, Stewart B.; Mahmoudi, Najet; McAuley, William J.; Cook, Michael T. (2021-12-11)Thermoreversible gels which transition between liquid‐like and solid‐like states when warmed have enabled significant novel healthcare technologies. Poly(N,N‐diethyl acrylamide) (PDEA) is a thermoresponsive polymer which ... -
Polymers exhibiting lower critical solution temperatures as a route to thermoreversible gelators for healthcare
Cook, Michael T.; Haddow, Peter; Kirton, Stewart; McAuley, William (2020-11-20)The ability to trigger changes to material properties with external stimuli, so-called “smart” behavior, has enabled novel technologies for a wide range of healthcare applications. Response to small changes in temperature ... -
Post-infectious visceral hypersensitivity persists in the TRPV1 knockout mouse
Keating, Christopher; Grundy, David (2009-05) -
Post-Operative Thoracic Epidural Analgesia and Incidence of Major Complications according to Specific Safety Standardized Documentation: A Large Retrospective Dual Center Experience
Sarridou, Despoina G; Mouratoglou, Sophia Anastasia; Mitchell, Jeremy; Cox, Felicia; Boutou, Afroditi; Braoudaki, Maria; Lambrou, George; Konstantinidou, Maria; Argyriadou, Heklena; Walker, Christopher (2023-11-29)(1) Background: Thoracic epidural analgesia is considered the gold standard in post-operative pain management following thoracic surgery. This study was designed to explore the safety of thoracic epidural analgesia and to ... -
Post-transcriptional divergence in the regulation of CAT-2A, CAT-2B and iNOS expression by dexamethasone in vascular smooth muscle cells
Thakur, Shori; Baydoun, A. R. (2012)Upregulation of l-arginine transport by pro-inflammatory mediators is a widely reported phenomenon which accompanies the expression of the inducible nitric oxide synthase (iNOS) enzyme in various cells. Both processes ... -
Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms
Gu, M.; Iravani, Mahmoud M.; Cooper, J.M.; King, Diane; Jenner, P.; Schapira, A. H. V. (2004-12)We have investigated the ability of pramipexole, a dopamine agonist used in the symptomatic treatment of Parkinson's disease (PD), to protect against cell death induced by 1-methyl-4-phenylpyridinium (MPP+) and rotenone ... -
Pramipexole protects against MPTP toxicity in non-human primates
Iravani, Mahmoud M.; Haddon, C. O.; Cooper, J. M.; Jenner, P.; Schapira, A. H. (2006-03)The neurotoxin MPTP induces nigral dopaminergic cell death in primates and produces a partial model of Parkinson's disease (PD). Pramipexole is a D-2/D-3 dopamine receptor agonist used in the symptomatic treatment of PD, ... -
Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research : Translatable and Bidirectional Research
Fisher, Amy; Lanigan, Michael; Upton, Neil; Lione, Lisa (2021-02-08)For patients suffering with chronic neuropathic pain the need for suitable novel therapies is imperative. Over recent years a contributing factor for the lack of development of new analgesics for neuropathic pain has been ... -
Prediction of binding modes for ligands in the cytochromes p450 and other heme-containing proteins
Kirton, S. B.; Murray, C. W.; Verdonk, M. L.; Taylor, R. D. (2005-03-01)The cytochromes P450 (P450s) are a family of heme-containing monooxygenase enzymes involved in a variety of functions, including the metabolism of endogenous and exogenous substances in the human body. During lead optimization, ... -
Prediction of ligands to universally conserved binding sites of the influenza A virus nuclear export protein
Patel, Hershna; Kukol, Andreas (2019-11-01)The nuclear export protein (NEP) of the influenza A virus exports viral ribonucleoproteins to the host cell cytoplasm following nuclear transcription. In this work conservation analysis of 3000 protein sequences and molecular ... -
The presence and the effects of neuropeptide Y in rat anococcygeus muscle
Iravani, Mahmoud M.; Zar, M. A. (1997-10-29)Isolated anococcygeus muscle from male rats was examined for the presence of neuropeptide Y-immunoreactive nerves and for the effects of neuropeptide Y on its tone and its contractile/relaxant responses to electrical field ... -
Presence of metals in herbal extracts
Guirguis, Amira; Owen, Jade; Stair, Jacqueline (2012-11-06)Do metals from raw herbs transport into herbal preparations during manufacture? Amira Guirguis and colleagues take a look at the issue using St John’s wort as an example. -
Presence of Neuropeptide-y in the rat seminal-vesicle and its effects on Noradrenaline-induced and nerve-induced contractions.
Iravani, Mahmoud M.; Zar, M. A. (1994-11)1 Immunohistochemical and functional studies have been performed to localize and determine the effects of neuropeptide Y (NPY) in the rat seminal vesicle. 2 An abundant presence of NPY-immunoreactive nerves, mainly ... -
Promoting innovation and excellence to face the rapid diffusion of Novel Psychoactive Substances (NPS) in the EU : the outcomes of the ReDNet project
Corazza, Ornella; Assi, Sulaf; Simonato, Pierluigi; Corkery, John; Bersani, Saverio; Demetrovics, Zsolt; Stair, Jacqueline; Fergus, Suzanne; Pezzolesi, Cinzia; Pasinetti, Manuela; Deluca, Paolo; Drummond, C.; Blaszko, Ursula; Moskalewicz, Jacek; Mervo, Barbara; Di Furia, Lucia; Farre, Magi; Flesland, Liv; Pisarska, Agnieszka; Shapiro, Harry; Siemann, Holger; Skutle, Arvid; Sferrazza, Elias; Torrens, Marta; Sambola, Farran; van der Kreeft, Peer; Scherbaum, Norbert; Schifano, Fabrizio (2013-07-25)Objectives: The recent emergence of new psychoactive compounds (NPS) has raised prominent challenges in the fields of drug policy, substance use research, public health and service provision. The Recreational Drugs European ... -
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems
MacInnes, Nicholas; Iravani, Mahmoud M.; Perry, Elaine; Piggott, Margaret; Perry, Robert; Jenner, Peter; Ballard, Clive (2008-06)Dementia with Lewy bodies (DLB) accounts for 15-20% of the millions of people worldwide with dementia. In the current work we investigate the association between proteasome dysfunction and the development of cortical Lewy ... -
The psychonauts’ benzodiazepines; quantitative structure-activity relationship (QSAR) analysis and docking prediction of their biological activity
Catalani, Valeria; Botha, Michelle; Corkery, John Martin; Guirguis, Amira; Vento, Alessandro; Scherbaum, Norbert; Schifano, Fabrizio (2021-07-26)Designer benzodiazepines (DBZDs) represent a serious health concern and are increasingly re-ported in polydrug consumption-related fatalities. When new DBZDs are identified, very limited information is available on their ... -
Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of post infectious bowel disease.
Rong, Weifang; Keating, Christopher; Sun, B.; Dong, L.; Grundy, David (2009-06)Increased sensitivity of the afferent innervation of the gastrointestinal tract reportedly underlies symptoms of discomfort and pain in functional bowel disorders. The present investigation aimed to examine whether the ... -
Quality of amoxicillin/clavulanic acid oral formulations for intended veterinary use in the UK, Malaysia, Serbia and Thailand
The Therapeutic Guidelines Group of the World Small Animal Veterinary Association; Pelligand, L.; Baker, D.; Sivagurunathan, A.; Kovačević, Z.; Suemanotham, N.; Stair, J. L.; Scott, M.; Liu, F.; Page, S. W.; Guardabassi, L.; Steagall, P. V. (2023-06-21)Objectives: Amoxicillin/clavulanate is the most commonly used oral antimicrobial drug in companion animals. The objective of the study was to detect types and frequency of deficits in the quality of veterinary oral ...