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Browsing by Author "Centre for Research in Mechanisms of Disease and Drug Discovery"
Now showing items 361-380 of 435
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Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L. (2005)The enzyme DDAH metabolizes methylarginines that are inhibitors of nitric oxide synthase (NOS). Substrate-based inhibitors of mammalian DDAH have been synthesized, with optimization to give selective inhibition of DDAH ... -
Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells
Stanczak, Michal A; Siddiqui, Shoib S; Trefny, Marcel P; Thommen, Daniela S; Boligan, Kayluz Frias; von Gunten, Stephan; Tzankov, Alexandar; Tietze, Lothar; Lardinois, Didier; Heinzelmann-Schwarz, Viola; von Bergwelt-Baildon, Michael; Zhang, Wu; Lenz, Heinz-Josef; Han, Younghun; Amos, Christopher I; Syedbasha, Mohammedyaseen; Egli, Adrian; Stenner, Frank; Speiser, Daniel E; Varki, Ajit; Zippelius, Alfred; Läubli, Heinz (2018-11-01)First-generation immune checkpoint inhibitors, including anti-CTLA-4 and anti-programmed death 1 (anti-PD-1) antibodies, have led to major clinical progress, yet resistance frequently leads to treatment failure. Thus, new ... -
Senescence and the Genome
Bridger, Joanna M; Foster, Helen (Springer Nature, 2020)Cellular senescence is commonly initiated in response to replicative or cell stress pathways. Senescent cells remain in a state of permanent cell cycle arrest and although being metabolically active, they exhibit distinct ... -
Senior lecturer to assessor: Appraisal of theories related to assessment from a new lecturer perspective
Lione, Lisa (2009-06-01)Essay style questions and multiple response questions (MRQs) have long formed the basis of unseen examination in higher education. These standard assessment methods have proven to be valid, reliable, effective and efficient. ... -
Sensor materials for the detection of proteases
Stair, Jacqueline L.; Watkinson, Michael; Krause, Steffi (2009-03-15)The concept of generic and tunable sensor materials for the detection of proteases based on the thin film degradation of peptide cross-linked dextran hydrogels was explored. Hydrogel cross-links were formed via simple imine ... -
Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes.
Ntoumou, Eleni; Tzetis, Maria; Braoudaki, Maria; Lambrou, George; Poulou, Myrto; Malizos, Konstantinos; Stefanou, Nikolaos; Anastasopoulou, L; Tsezou, Aspasia (2017-12-12)Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics ... -
A sex-linked Ace gene, not linked to insensitive acetylcholinesterase-mediated insecticide resistance in Culex pipiens
Malcolm, Colin; Bourguet, D.; Ascolillo, A.; Rooker, S. J.; Garvey, C. F.; Hall, L. M.; Pasteur, N.; Raymond, M. (1998-05)An acetylcholinesterase (AChE) gene, Ace.x, showing 93% identity of deduced amino acid sequence to Anopheles stephensi Ace has been cloned from a Culex pipiens strain homozygous for insensitive AChE (iAChE) mediated ... -
Short-term genome stability of serial Clostridium difficile ribotype 027 isolates in an experimental gut model and recurrent human disease
Eyre, David W.; Walker, A. Sarah; Freeman, Jane; Baines, Simon D.; Fawley, Warren N.; Chilton, Caroline H.; Griffiths, David; Vaughan, Alison; Crook, Derrick W.; Peto, Tim E. A.; Wilcox, Mark H. (2013-05-15)Clostridium difficile whole genome sequencing has the potential to identify related isolates, even among otherwise indistinguishable strains, but interpretation depends on understanding genomic variation within isolates ... -
Short-term genomic stability of Clostridium difficile within patients and a gut model
Eyre, D. W.; Ip, C.; Harding, R. M.; Freeman, J.; Baines, Simon D.; Fawley, W. N.; Walker, S.D.; Crook, D. W.; Peto, T. E. A.; Wilcox, M. H. (2011-09)Background: Clostridium difficile (CD) whole genome sequencing (WGS) has potential to identify related isolates for transmission studies, even among otherwise indistinguishable strains, but depends on understanding the ... -
Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis
Siddiqui, Shoib S; Dhar, Chirag; Sundaramurthy, Venkatasubramaniam; Sasmal, Aniruddha; Yu, Hai; Bandala-Sanchez, Esther; Li, Miaomiao; Zhang, Xiaoxiao; Chen, Xi; Harrison, Leonard C; Xu, Ding; Varki, Ajit (2021-03-09)Blood pH is tightly maintained between 7.35 and 7.45, and acidosis (pH <7.3) indicates poor prognosis in sepsis, wherein lactic acid from anoxic tissues overwhelms the buffering capacity of blood. Poor sepsis prognosis is ... -
Silencing of Essential Genes within a Highly Coordinated Operon in Escherichia coli
Goh, Shan; Hohmeier, Angela; Stone, Timothy C; Offord, Victoria; Sarabia, Francisco; Garcia-Ruiz, Cristina; Good, Liam (2015-08-15)Essential bacterial genes located within operons are particularly challenging to study independently because of coordinated gene expression and the nonviability of knockout mutants. Essentiality scores for many operon genes ... -
Simulation and experimental study of rheological properties of CeO2 – water nanofluid
Loya, Adil; Stair, Jacqueline; Ren, Guogang (2015-03)Metal oxide nanoparticles offer great merits over controlling rheological, thermal, chemical and physical properties of solutions. The effectiveness of a nanoparticle to modify the properties of a fluid depends on its ... -
Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration
Baskoylu, Saba N; Yersak, Jill; O'Hern, Patrick; Grosser, Sarah; Simon, Jonah; Kim, Sarah; Schuch, Kelsey; Dimitriadi, Maria; Yanagi, Katherine S; Lins, Jeremy; Hart, Anne C (2018-10-08)Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous work with SOD1 ... -
Site-specific examination of secondary structure and orientation determination in membrane proteins: The peptidic C-13=O-18 group as a novel infrared probe
Torres, J.; Kukol, A.; Goodman, J. M.; Arkin, I.T. (2001-11)Detailed site-specific information can be exceptionally useful in structural studies of macromolecules in general and proteins in particular. Stich information is usually obtained from spectroscopic studies using a label/probe ... -
SkelGen : a general tool for structure-based de novo ligand design
Dean, Philip M.; Firth-Clark, Stuart; Harris, William; Kirton, Stewart B.; Todorov, Nikolay P. (2006-07)The recent lapse in productivity in the pharmaceutical industry has facilitated the emergence of experimental and in silico structure-based design methodologies, based on identification of biologically active low molecular ... -
Small molecule recognition of mephedrone using an anthracene molecular clip
Kellett, Kathryn; Broome, J. Hugh; Zloh, Mire; Kirton, Stewart B.; Fergus, Suzanne; Gerhard, Ute; Stair, Jacqueline L.; Wallace, Karl J. (2016-05-16)An anthracene molecular probe has been synthesised and shown to target mephedrone, a stimulant drug from the cathinone class of new psychoactive substances (NPS). A protocol has been developed to detect mephedrone via the ... -
SMT19969 as a treatment for Clostridium difficile infection : an assessment of antimicrobial activity using conventional susceptibility testing and an in vitro gut model
Baines, Simon D.; Crowther, G. S.; Freeman, J.; Todhunter, S.; Vickers, R.; Wilcox, M. H. (2015-01-01)OBJECTIVES: We investigated the efficacy of the novel antimicrobial agent SMT19969 in treating simulated Clostridium difficile infection using an in vitro human gut model. METHODS: Concentrations of the predominant cultivable ... -
SMT19969 – a novel antibiotic for C. difficile : Clostridium difficile growth inhibition, spectrum of activity and resistance development
Vickers, R.; Tinsley, J.; Storer, R.; Wilson, F.; Dorgan, C.; Wren, S.; Wilcox, M. H.; Baines, Simon D.; Freeman, J. (2011-09)Background: C.difficile infection (CDI) is now established as a major healthcare issue. However, therapy options are limited and recurrent disease remains a significant problem. SMT19969 is the lead compound from a novel ... -
A Snapshot of photoresponsive liposomes in cancer chemotherapy and immunotherapy: opportunities and challenges
Youness, Rana A.; Hasan, Adham; Efthimiadou, Eleni; Mekky, Radwa; Braoudaki, Maria; Fahmy, Sherif Ashraf (2023-11-28)To provide precise medical regimens, photonics technologies have been involved in the field of nanomedicine. Phototriggered liposomes have been cast as promising nanosystems that achieve controlled release of payloads in ...