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Are placebo-controlled trials still important for obsessive compulsive disorder?
Fineberg, Naomi; Hawley, C.; Gale, T.M. (2006)The use of placebos as reference agents in randomised controlled trials for psychiatric disorders has come under question for ethical reasons. Alternative methods for validating the efficacy of new treatments exist, but ... -
Are undergraduate students studying smart? Insights into study strategies and habits across a programme of study
Fergus, Suzanne (2022-04-08)The approach that students take in their studies at university is critical not only for their academic success but is equally important in life-long learning for their career and professional development. Heutagogy is the ... -
Artificial Intelligence in Urological Oncology: An update and future applications
Brodie, Andrew; Dairu, Dai; Teoh, Jeremy; Decaestecker, Karel; Dasgupta, Prokar; Vasdev, Nikhil (2021-05-20)There continues to be rapid developments and research in the field of Artificial Intelligence (AI) in Urological Oncology worldwide. In this review we discuss the basics of AI, application of AI per tumour group (Renal, ... -
Arylalkylpiperazines for use as neuroprotective agents : Arlyalkylpiperazines and neuroprotection
Basic and Clinical Science Unit; School of Life and Medical Sciences; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Iravani, Mahmoud (2016-04-07)A compound of the general formula A or a or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is selected from the group consisting of: C1-C12-alkyl, C3-C12-cycloalkyl, C6- C10-aryl, and C5-C7-heteroaryl; ... -
Assessing problematic use of social media: where do we stand and what can be improved?
Cataldo, Ilaria; Billieux, Joël; Esposito, Gianluca; Corazza, Ornella (2022-06-01)The increased popularity of social media has brought clinicians and researchers to question the potential problematic outcomes of such Internet-based applications. Over the past two decades, an increasing number of studies ... -
Assessing the 2004-2018 fentanyl misusing issues reported to an international range of adverse reporting systems
Schifano, Fabrizio; Chiappini, Stephania; Corkery, John; Guirguis, Amira (2019-02-01)Objective: A recent, global, increase in the use of opioids including the prescribing, highly potent, fentanyl has been recorded. Due its current popularity and the potential lethal consequences of its intake, we aimed ... -
Assessing the integration of pharmacist independent prescribers in child and adolescent mental health services
Shah, Chetan; Umaru, Nkiruka; Adams, Eleanor; Johal, Mandeep; Faridi, Arshad; Kah, Mirza; Zia, Asif; Magon, Rakesh (2021-04-01)Introduction: Owing to high demand and staff recruitment challenges, child and adolescent mental health services (CAMHS) in England have struggled to meet expectations set by the NHS and Royal College of Psychiatrists ... -
Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: An European and Asia-Pacific Expert Consensus Paper
Gorog, Diana; Gue, Ying X.; Chao, Tze-Fan; Fauchier, Laurent; Ferreiro, Jose Luis; Huber, Kurt; Konstantinidis, Stavros V; Lane, Deirdre A; Marin, Francisco; Oldgren, Jonas; Potpara, Tatjana; Roldan, Vanessa; Rubboli, Andrea; Sibbing, Dirk; Tse, Hung-Fat; Vilahur, Gemma; Lip, Gregory Y H (2022-03-22)Whilst there is a clear clinical benefit of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and venous thromboembolism (VTE) in reducing the risks of thromboembolism, major bleeding events (especially ... -
The assessment of cyberchondria: Instruments for assessing problematic online health-related research
Starcevic, Vladan; Berle, David; Arnáez, Sandra; Vismara, Matteo; Fineberg, Naomi (2020-04-30)Purpose of review: Cyberchondria is a problematic, i.e., distressing or anxiety-increasing pattern of online health information seeking. The development of psychometrically sound instruments for the assessment of cyberchondria ... -
Assessment of endogenous fibrinolysis in clinical using novel tests - Ready for clinical roll-out?
Gue, Ying X.; Ding, Wern Yew; Lip, Gregory Y H; Gorog, Diana (2021-04-01)The occurrence of thrombotic complications, which can result in excess mortality and morbidity, represent an imbalance between the pro-thrombotic and fibrinolytic equilibrium.The mainstay treatment of these complications ... -
Assessment of the effectiveness and efficiency of the economic community of West African States Medicines Regulatory Harmonization initiative by the pharmaceutical industry
Owusu-Asante, Mercy; Darko, Delese Mimi; Walker, Stuart; Salek, Sam (2023-05-09)Background: Following the establishment of Economic Community of West African States Medicines Regulatory Harmonization (ECOWAS-MRH) initiative in 2017, it was considered timely to carry out an evaluation of the current ... -
Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery : Combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds
Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick; Gough, Andrew; Devlin, Joe; Emery, Paul; Waterhouse, Lynn; James, David; Tate, Helen; Boys, Cathy; Williams, Peter; White, Dora; Dart, Helen; Winfield, John; Seymour, Annie; Williams, Richard; Blunn, Karina; McDowell, Jackie; Prouse, Peter; Andrews, Sheryl; Wilson, Deborah; Magliano, Malgorzata; Perks, Ursula; Coulson, Amanda; Hassle, Andrew; Kirwan, Michele; Leone, Francesca; Dunne, Ciaran; Hawley, Lindsey; Creamer, Paul; Taylor, Julie; Wilmott, Wendy; Knights, Sally; Rowland-Axe, Rebecca; Green, Sandra; Simmons, Dawn; David, Joel; Cox, Maureen; Bukhari, Marwan; Evans, Bronwen; Batley, Michael; Oram, Catherine; ERAS and ERAN (2016-11-10)Objectives: To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods: Health Assessment Questionnaire (HAQ) disability scores ... -
The association between social deprivation and disease activity in rheumatoid arthritis: A systematic literature review
Dey, Mrinalini; Busby, Amanda; Ewell, Helen; Lempp, Heidi; Pratt, Arthur; Young, Adam; Isaacs, John; Nikiphorou, Elena (2022-04-21)Physical and mental illnesses are driven by ethnicity, social, environmental and economic determinants. Novel theoretical frameworks in rheumatoid arthritis (RA) focus on links and adverse interactions between and within ... -
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response
Viatte, Sebastien; Plant, Darren; Han, Buhm; Fu, Bo; Yarwood, Annie; Thomson, Wendy; Symmons, Deborah P.M.; Worthington, Jane; Young, Adam; Hyrich, Kimme L.; Morgan, Ann W.; Wilson, Anthony G.; Isaacs, John D.; Raychaudhuri, Soumya; Barton, Anne (2015-04-28)IMPORTANCE: Advances have been made in identifying genetic susceptibility loci for autoimmune diseases, but evidence is needed regarding their association with prognosis and treatment response. OBJECTIVE: To assess whether ... -
Attitudes in Patients with Autosomal Dominant Polycystic Kidney Disease Toward Prenatal Diagnosis and Preimplantation Genetic Diagnosis
Swift, Oscar; Vilar, Enric; Rahman, Belinda; Side, Lucy; Gale, Daniel P (2016-12-01)AIMS: No recommendations currently exist regarding implementation of both prenatal diagnosis and preimplantation genetic diagnosis (PGD) for autosomal dominant polycystic kidney disease (ADPKD). This study evaluated attitudes ... -
Availability of Illegal Drugs During the COVID-19 Pandemic in Western Germany
Scherbaum, Norbert; Bonnet, Udo; Hafermann, Henning; Schifano, Fabrizio; Bender, Stefan; Grigoleit, Torsten; Kuhn, Jens; Nyhuis, Peter; Preuss, Ulrich W; Reymann, Gerhard; Schneider, Udo; Shibata, Jo; Specka, Michael (2021-04-23)Background: In response to the COVID-19-pandemic, a lockdown was established in the middle of March 2020 by the German Federal Government resulting in drastic reduction of private and professional traveling in and out of ... -
Avoid jumping to conclusions under uncertainty in Obsessive Compulsive Disorder
Morein-Zamir, Sharon; Shahper, Sonia; Gasull-Camos, Julia; Fineberg, Naomi; Robbins, Trevor (2020-01-15)High levels of intolerance of uncertainty (IU) could contribute to abnormal decision making in uncertain situations. Patients with Obsessive Compulsive Disorder (OCD) often report high IU, indecisiveness and the need to ... -
Banning psychoactive substances is not enough, we need education too.
Lione, Lisa (2016-06-06) -
Baricitinib for previously treated moderate or severe rheumatoid arthritis: : An Evidence Review Group perspective of a NICE Single Technology Appraisal
Ren, S; Bermejo, Iñigo; Simpson, Emma L; Wong, R.; Scott, D; Young, Keith; Stevenson, Matt D (2018-07-01)As part of its single technology appraisal process, the National Institute for Health and Care Excellence invited the manufacturer (Eli Lilly) of baricitinib (BARI; Olumiant®; a Janus kinase inhibitor that is taken orally) ... -
Barriers to implementing antimicrobial stewardship programmes in three Saudi hospitals: Evidence from a qualitative study
Alghamdi, Saleh; Shebl, Nada; Aslanpour, Zoe; Berrou, Ilhem (2019-09-01)Objectives: This study explored antimicrobial stewardship programme (ASP) team members’ perspectives regarding factors influencing the adoption and implementation of these programmes in Saudi hospitals. Methods: This was ...