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Behaviour Change Strategies to Influence Antimicrobial Stewardship During COVID-19 Pandemic in acute care settings.
Abdelsalam Elshenawy, Rasha; Umaru, Nikkie; Aslanpour, Zoe (2021-06-22)This research explores the effectiveness of Antimicrobial Stewardship (AMS) interventions, focusing on behavioural change strategies during the COVID-19 pandemic in acute care settings. Employing a systematic literature ... -
Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets
Dass, B.; Iravani, Mahmoud M.; Jackson, M. J.; Engber, T. M.; Galdes, A.; Jenner, P. (2002)Sonic hedgehog (SHH) has trophic actions on dopaminergic cell cultures and protects them from MPP+ toxicity but its in vivo actions have not been explored. We now investigate the effects of unilateral supranigral administration ... -
The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions
Zloh, Mire; Kirton, Stewart (2018-02-01)The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative platforms. The evolution of computational ... -
Benzodiazepine Boom: Tracking Etizolam, Pyrazolam, and Flubromazepam from Pre-UK Psychoactive Act 2016 to Present Using Analytical and Social Listening Techniques
Mullin, Anthony; Scott, Mark; Vaccaro, Giorgia; Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Corkery, John M; Stair, Jacqueline L; Schifano, Fabrizio; Guirguis, Amira (2024-01-12)Introduction: The designer benzodiazepine (DBZD) market continues to expand whilst evading regulatory controls. The widespread adoption of social media by pro-drug use communities encourages positive discussions around ... -
The benzydamine experience: A systematic review of Benzydamine abuse
Chiappini, Stephania; Miuli, Andrea; Mosca, Alessio; Pettorruso, Mauro; Guirguis, Amira; Corkery, John Martin; Martinotti, Giovanni; di Giannantonio, Massimo; Schifano, Fabrizio (2021-01-13)Background: Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally ... -
Beta-glucans in advanced CKD : role in endotoxaemia and inflammation
Wong, Jonathan; Zhang, Yonglong; Swift, Oscar; Finkelman, Malcolm; Patidar, Ashish; Ramanarayanan, Sivaramakrishnan; Vilar, Enric; Farrington, Ken (2020-04-06)BACKGROUND/AIMS: (1-3)-β-D glucans (BG) are cellular components of yeasts and fungi. Elevated blood levels may be an adjunct in diagnosing invasive fungal infection, though can be high in dialysis patients without fungaemia. ... -
Beyond the Purple Drank. Study of promethazine abuse according to the European Medicines Agency (EMA) Adverse Drug Reactions (ADR) reports.
Chiappini, Stefania; Schifano, Fabrizio; Corkery, John Martin; Guirguis, Amira (2021-01-10)Background: Promethazine is a medicinal product, available on its own or in combination with other ingredients including dextromethorphan, paracetamol, and/or expectorants. Anecdotal reports have however indicated that ... -
Bicyclic 6-6 Systems: Pteridines
Rossiter, Sharon; Ostovar, Mehrnoosh (Elsevier, 2022)This article describes the literature on pteridines, covering the period from 2008 to 2020. The physical properties and reactions include photochemistry, substitution at ring nitrogens, nucleophilic substitution at ring ... -
Biomarkers in Bladder Cancer Surveillance
Sugeeta, Sukumar S.; Sharma, Anand; Ng, Kenrick; Nayak, Arvind; Vasdev, Nikhil (2021-09-28)Aim: This is a narrative review with an aim to summarise and describe urinary biomarkers in the surveillance of non-muscle-invasive bladder cancer (NMIBC). It provides a summary of FDA-approved protein biomarkers along ... -
Biomarkers in Bladder Cancer Survellance
Sugeeta, SS; Sharma, A.; Ng, K; Nayak, A; Vasdev, Nikhil (2021-09-28)Aim: This is a narrative review with an aim to summarise and describe urinary biomarkers in the surveillance of non-muscle-invasive bladder cancer (NMIBC). It provides a summary of FDA-approved protein biomarkers along ... -
Biomarkers of Thrombotic Status Predict Spontaneous Reperfusion in Patients With ST-Segment Elevation Myocardial Infarction
Kanji, Rahim; Gue, Ying X.; Memtsas, Vassilios; Spencer, Neil H.; Gorog, Diana (2023-05-16)Background Spontaneous reperfusion, seen in ∼20% of patients with ST-segment elevation myocardial infarction (STEMI), manifests as normal epicardial flow in the infarct-related artery, with or without ST-segment resolution, ... -
Bioprosthetic valve thrombosis and degeneration following transcatheter aortic valve implantation (TAVI)
Mirsadraee, Saeed; Gorog, Diana (2020-09-09)Bioprosthetic valve thrombosis (BPVT) is a recognised complication of prosthetic aortic valves and can be seen in up to 13% of patients after transcatheter implantation.The mechanism of BPVT is not well known, abnormal ... -
Blue light transurethral resection and biopsy of bladder cancer with hexaminolevulinate: Histopathological characteristics and recurrence rates in a single UK centre study
Chan, Kimberley; Hampson, Alexander; Hayes, John; Rabinowitz, Joshua; Vasdev, Nikhil (2023-09-30)Introduction: Blue light cystoscopy with hexaminolevulinate (HAL) during transurethral resection of bladder cancer (TURBT) has been shown to improve detection, thereby reducing bladder cancer recurrence compared with white ... -
Body dysmorphic disorder: a treatment synthesis and consensus on behalf of the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) and the Obsessive Compulsive and Related Disorders Network (OCRN) of the European College of Neuropsychopharmacology (ECNP)
Castle, David; Beilharz, Francesca; Phillips, Katharine A; Brakoulias, Vlasios; Drummond, Lynne M; Hollander, Eric; Ioannidis, Konstantinos; Pallanti, Stefano; Chamberlain, Samuel R.; Rossell, Susan L; Veale, David; Wilhelm, Sabine; Van Ameringen, Michael; Dell'Osso, Bernardo; Menchon, Jose M.; Fineberg, Naomi (2021-03-30)Body dysmorphic disorder (BDD) is characterised by a preoccupation with a perceived appearance flaw or flaws that are not observable to others. BDD is associated with distress and impairment of functioning. Psychiatric ... -
The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective
Orsolini, Laura; Chiappini, Stephania; Papanti, Duccio; De Berardis, Domenico; Corkery, John Martin; Schifano, Fabrizio (2019-11-20)The critical spread and dissemination of novel psychoactive substances (NPS), particularly among the most vulnerable youngsters, may pose a further concern about the psychotic trajectories related to the intake of new ... -
The Burden of Comorbidity Between Bipolar Spectrum and Obsessive-Compulsive Disorder in an Italian Community Survey
Carta, Mauro Giovanni; Fineberg, Naomi; Moro, Maria Francesca; Preti, Antonio; Romano, Ferdinando; Balestrieri, Matteo; Caraci, Filippo; Dell'Osso, Liliana; Disciascio, Guido; Drago, Filippo; Hardoy, Maria Carolina; Roncone, Rita; Minerba, Luigi; Faravelli, Carlo; Angst, Jules (2020-03-31)Background: The impact of the comorbidity between Obsessive-Compulsive Disorder (OCD) and Bipolar Disorder Spectrum (BDS) remains to be clarified. The objective of this study was to examine the lifetime prevalence of OCD, ... -
The Burden of Disease in Pyruvate Kinase Deficiency: Patients' Perception of the Impact on Health-Related Quality of Life
Grace, RF; Cohen, L; Egan, S; Wells, T; Witherspoon, B; Ryan, A; Salek, Mir-Saeed Shayegan; Bodie, S; Klaassen, RJ (2018-12-01)Objectives: This study explored how signs and symptoms of pyruvate kinase (PK) deficiency, a rare hemolytic anemia caused by mutations in the PKLR gene, impacts patients’ health-related quality of life (HRQoL). Methods: ... -
Buvidal: is it really a ‘game changer’ in the treatment of problematic opioid use?
Holloway, Kate; Schifano, Fabrizio (2023-11-30) -
Can mobile phone technology support a rapid sharing of information on Novel Psychoactive Substances among health and other professionals internationally?
Simonato, Pierluigi; Bersani, Francesco Saverio; Santacroce, Rita; Cinosi, Eduardo; Schifano, Fabrizio; Bersani, Giuseppe; Martinotti, Giovanni; Corazza, Ornella (2017-06-28)Background The diffusion of Novel Psychoactive Substances (NPSs), combined with the ability of the Internet to act as an online marketplace, has led to unprecedented challenges for governments, health agencies, and substance ... -
Cannabidiol (CBD) Use in Psychiatric Disorders; A Systematic Review
Bonaccorso, Stefania; Ricciardi, Angelo; Zangani, Caroline; Chiappini, Stefania; Schifano, Fabrizio (2019-09)Cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) are the most represented phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different activity compared with the psychotomimetic THC. Most ...