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The influence of dietary supplementation with urea on resilience and resistance to infection with Haemonchus contortus
Wallace, D.S.; Bairden, K.; Duncan, J.L.; Eckersall, P.D.; Fishwick, G.; Gill, M.; Holmes, P.H.; McKellar, Quintin; Murray, M.; Parkins, J.J. (1998-01)Previous research has indicated that supplementing an apparently adequate diet with additional protein improves both host resistance and resilience in lambs infected with Haemonchus contortus. The present study tested the ... -
The influence of increased feeding on the susceptibility of sheep to infection with Haemonchus contortus
Wallace, D.S.; Bairden, K.; Duncan, J.L.; Eckersall, P.D.; Fishwick, G.; Holmes, P.H.; McKellar, Quintin; Mitchell, S.; Murray, M.; Parkins, J.J. (1999-10)Previous research has shown that supplementing the diet of growing lambs with urea enhances their ability to withstand gastrointestinal infection with the nematode Haemonchus contortus. This study compared lambs given two ... -
The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs
Debackere, M.; Landuyt, J.; Vercruysse, J.; McKellar, Quintin (1993-09)Plasma concentrations of febantel and its major metabolites fenbendazole, oxfendazole and oxfendazole sulphone were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection ... -
The influence of relative resistance and urea-supplementation on deliberate infection with<i> Teladorsagia circumcincta during winter
Stear, M.J.; Bairden, K.; Duncan, J.L.; Eckersall, P.D.; Fishwick, G.; Graham, P.A.; Holmes, P.H.; McKellar, Quintin; Mitchell, S.; Murray, M. (2000-12-20)The consequences for lambs of infection over the winter with Teladorsagia circumcincta were quantified by deliberate, trickle infection of selected animals at 7 months of age. Infected and control uninfected animals were ... -
Influence of soyabean meal supplementation on the resistance of Scottish Blackface lambs to haemonchosis
Wallace, D.S.; Bairden, K.; Duncan, J.L.; Fishwick, G.; Gill, M.; Holmes, P.H.; McKellar, Quintin; Murray, M.; Parkins, J.J.; Stear, M. (1996-03)Protein supplementation improves the resistance of sheep to haemonchosis. This experiment investigated the Scottish blackface breed to establish whether dietary protein supplementation is still beneficial in a genetically ... -
Influence of supplementation with dietary soyabean meal on resistance to haemonchosis in Hampshire Down lambs
Wallace, D.S.; Bairden, K.; Duncan, J.L.; Fishwick, G.; Gill, M.; Holmes, P.H.; McKellar, Quintin; Murray, M.; Parkins, J.J.; Stear, M.J. (1995-05)The influence of dietary protein supplementation on resistance to haemonchosis was examined in Hampshire down lambs fed either a basal diet or a diet supplemented with soyabean. At seven months of age the lambs were ... -
Interaction between fenbendazole and piperonyl butoxide : pharmacokinetic and pharmacodynamic implications
Benchaoui, H. A.; McKellar, Quintin (1996-07)The effect of the cytochrome P450 inhibitor, piperonyl butoxide on the pharmacokinetics and anthelmintic efficacy of the benzimidazole compound fenbendazole was studied in sheep and goats. Pretreatment of goats with the ... -
Interactions of Ostertagia species with their bovine and ovine hosts
McKellar, Quintin (1993-07)Ostertagia spp. affect their hosts in several complex interactions involving structural, biochemical, hormonal, nutritional and immunological mechanisms. Following infection with Ostertagia spp. the specialised secretory ... -
Intramammary treatment of mastitis in cows
McKellar, Quintin (1991) -
Ionophores : potential toxicities
McKellar, Quintin; Lawrence, K. (1996)The ionophores are a group of antibiotics produced by the fermentation of fungal [i]Streptomyces[/i] species which have activity against some Gram-positive bacteria, coccidia, [i]Neospora[/i] and [i]Toxoplasma[/i]. The ... -
Isometamidium in goats : disposition kinetics, mammary excretion and tissue residues
Kinabo, L. D.; McKellar, Quintin (1990-09)The pharmacokinetics of the antitrypanosomal drug isometamidium were studied in lactating goats after intravenous and intramuscular administration at a dose of 0.5 mg/kg body weight, in a crossover design at an interval ... -
Isometamidium in pigs : disposition kinetics, tissue residues and adverse reactions
Kinabo, L. D.; McKellar, Quintin; Eckersall, P. D. (1991-01)The disposition and adverse effects of the anti-trypanosomal drug isometamidium in pigs were evaluated. Following intramuscular administration of the drug at doses of 0.5, 15 and 35 mg kg-1, the drug was rapidly absorbed ... -
Local and plasma antibody responses to the parasitic larval stages of the abomasal nematode Ostertagia circumcincta
Sinski, E.; Bairden, K.; Duncan, J. L.; Eisler, M. C.; Holmes, P. H.; McKellar, Quintin; Murray, M.; Stear, M. J. (1995-09)Ovine isotype-specific antibody responses to the parasitic larval stages of the abomasal nematode Ostertagia circumcincta were measured in a simple, indirect enzyme-linked immunosorbent assay. Analysis of variance of ... -
Measurement of cyclooxygenase inhibition in vivo : a study of two non-steroidal anti-inflammatory drugs in sheep
Cheng, Z.; Nolan, A.M.; McKellar, Quintin (1998-08)The anti-inflammatory effects of the non-steroidal anti-inflammatory drugs phenylbutazone (PBZ) and flunixin meglumine (FM) and the relationship between the effects and drug concentration in vivo were studied using a ... -
Method for the growth of equine airway epithelial cells in culture
Sime, A. A. W.; McKellar, Quintin; Nolan, A. M. (1997-01)A serum-free cell culture method was developed for equine tracheal epithelial cells which allowed the growth and characterisation of the phenotypical properties of this cell type. Several variables influenced the efficacy ... -
The molecular epidemiology of tuberculosis in inner London
Hayward, A.C.; Goss, S.; Dobniewski, F.; Saunders, N.; Shaw, R.J.; Goyal, Madhu; Swan, A.; Uttley, A.; Pozniak, A.; Grace-Parker, J.; Watson, J.M. (2002) -
Multiple forms of bovine pepsinogen : isolation and identification in serum from calves with ostertagiasis
Eckersall, P. D.; Macaskill, J.; McKellar, Quintin; Bryce, K. L. (1987-11)By using fast protein liquid chromatography (FPLC) a new form of bovine pepsinogen has been identified. Compared with the previously isolated pepsinogen (PG I) the new pepsinogen (PG II) is less mobile on agarose ... -
Oral absorption and bioavailability of fenbendazole in the dog and the effect of concurrent ingestion of food
McKellar, Quintin; Galbraith, E. A.; Baxter, P. (1993-06)Fenbendazole was administered orally without food to six beagle dogs at 2.5, 5.0, 10, 20, 40 and 80 mg/kg of body weight. Increasing the dose rate did not significantly increase the amount of fenbendazole absorbed. In a ... -
Otitis externa in a foxhound pack associated with Candida albicans
McKellar, Quintin; Rycroft, A.; Anderson, L.; Love, J. (1990) -
An ovine lymphocyte antigen is associated with reduced faecal egg counts in four-month-old lambs following natural, predominantly Ostertagia circumcincta infection
Stear, M.J.; Bairden, K.; Bishop, S.C.; Buitkamp, J.; Epplen, J.T.; Gostomski, D.; McKellar, Quintin; Schwaiger, F.W.; Wallace, D.S. (1996-04)Ten lymphocyte antigens were defined in a flock of Scottish Blackface sheep known to be naturally exposed to infection with Ostertagia circumcincta. Population and family studies suggested that the 10 antigens were products ...