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Efficacy of ivermectin against Cooperia curticei infection in sheep
Bogan, J. A.; McKellar, Quintin; Mitchell, E. S.; Scott, E. W. (1988)Lambs were inoculated with a single dose of Cooperia curticei. Subcutaneous administration of ivermectin at a dosage of 200 micrograms/kg of body weight resulted in 61.1% and 90.4% anthelmintic efficacy, when measured at ... -
Enantioselective pharmacokinetics and cyclo-oxygenase inhibition of carprofen and carprofen enantiomers in sheep
Cheng, Z.; Nolan, A.; Monteiro, A.; McKellar, Quintin (2003-10) -
Eosinophilia as a marker of resistance to Teladorsagia circumcincta in Scottish Blackface lambs
Stear, M.J.; Henderson, N.G.; Kerr, A.; McKellar, Quintin; Mitchell, S.; Seeley, C.; Bishop, S.C. (2002-05) -
Factors affecting the clinical outcome of injuries to the superficial digital flexor tendon in National Hunt and point-to-point racehorses.
Marr, C.M.; Love, S.; Boyd, J.S.; McKellar, Quintin (1993-05-08)Ultrasonographic examination was used to define the severity of injuries to the superficial digital flexor tendon in 73 National Hunt or point-to-point racehorses and the factors influencing the outcome of the cases were ... -
Fenbendazole pharmacokinetics, metabolism, and potentiation in horses
McKellar, Quintin; Gokbulut, C.; Muzandu, K.; Benchaoui, H. (2002-11)The present study was designed to describe the pharmacokinetics and fecal excretion of fenbendazole (FBZ) and fenbendazole sulphoxide (FBZSO) and their metabolites in horses, to investigate the effects which concurrent ... -
Flunixin pharmacokinetics and serum thromboxane inhibition in the dog
McKellar, Quintin; Galbraith, E. A.; Bogan, J. A.; Russell, C. S.; Hooke, R. E.; Lees, P. (1989)Flunixin meglumine administered orally to beagle dogs at doses of 0.55, 1.10 or 1.65 mg/kg bodyweight was rapidly absorbed to produce maximum mean plasma concentrations of 2.40 +/- 0.70, 4.57 +/- 1.12 and 7.42 +/- 2.07 ... -
Forms of bovine pepsinogen in plasma from cattle with three different 'syndromes' of Ostertagia ostertagi infection
McKellar, Quintin; Eckersall, P. D.; Duncan, J. L.; Armour, J. (1988-01)Calves infected orally with third stage larvae of Ostertagia ostertagi or infected with adult O ostertagi by direct transplantation into the abomasum had raised plasma pepsinogen activity, as did four-year-old dairy cattle ... -
Fructosamine concentration and resistance to natural, predominantly Teladorsagia circumcincta infection
Stear, M.J.; Eckersall, P.D.; Graham, P.A.; McKellar, Quintin; Mitchell, S.; Bishop, S.C. (2001-08)Fructosamine con cent rations reflect protein status and because infection with Teladorsagia circumcineta can induce a relative protein deficiency, we examined the usefulness of fructosamine concentrations as markers of ... -
Further studies on the response to transplanted adult Ostertagia ostertagi in calves
McKellar, Quintin; Duncan, J. L.; Armour, J.; Lindsay, F. E.; McWilliam, P. (1987-01)Calves infected by surgical transplantation of adult Ostertagia ostertagi had raised levels of plasma pepsinogen and those in which the largest number of worms established also had elevated plasma gastrin concentrations. ... -
The genetic basis of resistance to Ostertagia circumcincta in lambs
Stear, M.J.; Bairden, K.; Bishop, S.C.; Buitkamp, J.; Duncan, J.L.; Gettinby, G.; McKellar, Quintin; Park, M.; Parkins, J.J.; Reid, S.W.J. (1997-09)The relationship between Ostertagia (Teladorsagia) circumcincta and sheep is one of the best understood host-parasite relationships in any species. The key components of resistance have been quantified, the extent of genetic ... -
The genetic control of IgA activity against Teladorsagia circumcincta and its association with parasite resistance in naturally infected sheep
Strain, S.A.J.; Bishop, S.C.; Henderson, N.G.; Kerr, A.; McKellar, Quintin; Mitchell, S.; Stear, M.J. (2002-05)Previous studies in deliberately infected sheep have shown an association between IgA activity against 4th-stage larvae of Teladorsagia circumcincta and parasite growth, development and fecundity. The purpose of this ... -
Genetic Diversity of Mycobacterium tuberculosis Complex Strains Isolated from Patients with Pulmonary Tuberculosis in Anambra State, Nigeria
Uzoewulu, Gertrude; Lawson, Lovett; Nnanna, Ibeh; Rastogi, Nalin; Goyal, Madhu (2017-02-08)In this study, we analyzed Mycobacterium tuberculosis complex (MTC) genetic diversity in Anambra State, Nigeria based on spoligotyping followed by 5-loci exact tandem repeats (ETRs). Spoligotyping of 180 MTC strains isolated ... -
Genetic parameters for faecal egg count following mixed, natural, predominantly Ostertagia circumcinta infection and relationships with live weight in young lambs
Bishop, S.C.; Bairden, K.; McKellar, Quintin; Park, M.; Stear, M.J. (1996-12)Faecal egg counts and live weights were measured on approximately 200 predominantly twin-born Scottish Blackface lambs each year for 3 years, from 2 to 6 months of age. Measurements were made at 4-week intervals following ... -
The health of the sheep industry and the medicines to maintain it
McKellar, Quintin (2006)The global sheep industry is changing dramatically to serve its diverse customers and in response to liberalised international trade agreements and resculptured (reduced) national subsidies. A drive for efficiency gains ... -
A high performance liquid chromatographic method for the determination of febantel and its major metabolites in lamb plasma
Landuyt, J.; Debackere, M.; Delbeke, F.; McKellar, Quintin (1993-03)A high performance liquid chromatographic (HPLC) method for the determination of the anthelminthic pro-benzimidazole febantel and its major metaboites in lamb plasma has been developed. Samples were extracted after addition ... -
How hosts control worms
Stear, M.J.; Bairden, K.; Duncan, J.L.; Holmes, P.H.; McKellar, Quintin; Park, M.; Strain, S.; Murray, M.; Bishop, S.C.; Gettinby, G. (1997-09-04)Nematodes are a major cause of disease and death in humans, domestic animals and wildlife. Understanding why some individuals suffer severely whereas others exposed to the same infection remain healthy may assist in the ... -
Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds
Anagani, Bhavani; Singh, Jagbir; Bassin, Jatinder; Besra, Gurdyal; Benham, Christopher; Reddy, Tummala Rama Krishna; Cox, Jonathan; Goyal, Madhu (2020-05-18)Objectives: The search for new TB drugs has become one of the great challenges for modern medicinal chemistry. An improvement in the outcomes of TB chemotherapy can be achieved by the development of new, shorter, cheap, ... -
Immunological studies of bovine pepsinogen and problems in the development of an Elisa for Ostertagiasis
Mostofa, M.; McKellar, Quintin; Eckersall, P. D. (1995) -
The influence of a heavy infection with sensitive and resistant strains of Ostertagia circumcincta and with Trichostrongylus colubriformis on the pharmacokinetics of febantel in lambs
Landuyt, J.; Debackere, M.; Vercruysse, J.; McKellar, Quintin (1995-06)Plasma concentrations of febantel and its major metabolites, fenbendazole, oxfen-dazole and fenbendazole sulphone, were determined after oral administration of 7.5 mg/kg febantel in lambs before and 28 days after infection ... -
The influence of age on the variation among sheep in susceptibility to natural nematode infection
Stear, M.J.; Mitchell, S.; Strain, S.; Bishop, S.C.; McKellar, Quintin (2000-03-28)A longitudinal study of faecal nematode egg counts was made in naturally infected Scottish Blackface sheep over two grazing seasons to 75 weeks of age. Although egg counts were lower in the second grazing season the variation ...