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Disposition of penicillin G sodium following intravenous and oral administration to Equidae
Horspool, L. J.; McKellar, Quintin (1995)The present study was designed to determine and compare the plasma disposition and pharmacokinetics of penicillin G sodium following intravenous (i.v.) administration to horses, ponies and donkeys. The plasma disposition ... -
The distribution and some pharmacokinetic parameters of ivermectin in pigs
Scott, E. W.; McKellar, Quintin (1992-03)Ivermectin was injected subcutaneously into five pigs at the usual dose rate of 300 micrograms/kg and found to distribute well to all tissues and body fluids which were sampled 24 h post-injection. Ivermectin was detected ... -
The distribution of faecal nematode egg counts in Scottish Blackface lambs following natural, predominantly Ostertagia circumcincta infection
Stear, M. J.; Bairden, K.; Duncan, J. L.; Gettinby, G.; McKellar, Quintin; Murray, M.; Wallace, D. S. (1995-05)Faecal samples were taken in 2 consecutive years from Scottish Blackface lambs on a commercial farm in central Scotland to examine variation among lambs in the number of nematode eggs in their faeces. Samples were taken ... -
Distribution of oxytetracycline in normal and diseased ovine lung tissue
Baxter, P.; McKellar, Quintin (1990) -
The distribution of pepsinogen within the abomasa of cattle and sheep infected with Ostertagia spp. and sheep infected with Haemonchus contortus
Scott, I.; Dick, A.; Irvine, J.; Stear, M.J.; McKellar, Quintin (1999-03-31)The effect of nematode infections on the production of pepsinogen by ruminants was investigated immunohistochemically and biochemically. Abomasal tissues were collected from parasite-naive cattle and sheep, from sheep ... -
Drug dosages for small mammals
McKellar, Quintin (1989) -
Ecotoxicology and residues of anthelmintic compounds
McKellar, Quintin (1997-11)Anthelmintics and endectocides used for the treatment and prophylaxis of Ostertagia sp. in ruminants include benzimidazoles, levamisole, morantel and the avermectins and milbemycins. Most of these agents are excreted to ... -
Effect of an antimuscarinic drug on the plasma pepsinogen activity of sheep infected with Ostertagia circumcincta
Mostofa, M.; McKellar, Quintin (1989)The antimuscarinic drug atropine caused a marked fall in plasma pepsinogen values of sheep with burdens of Ostertagia circumcincta and this response was greater in animals which had higher plasma pepsinogen values before ... -
Effect of changes in urine pH on plasma pharmacokinetic variables of ampicillin sodium in horses
Sarasola, P.; Horspool, L. J.; McKellar, Quintin (1992)The effect of urine pH on plasma disposition of ampicillin sodium was evaluated. A single dose of 10 mg/kg of body weight was administered IV to Thoroughbreds with alkaline (pH greater than 8.0) or acidic (pH less than ... -
Effect of early treatment with rafoxanide on antipyrine clearance in sheep infected with Fasciola hepatica
Benchaoui, H. A.; McKellar, Quintin (1993-01)1. The effect of the salicylanilide compound rafoxanide against immature stages of Fasciola hepatica was investigated in sheep using a series of antipyrine clearance tests and measuring glutamate dehydrogenase and ... -
Effect of ivermectin on the reproductive potential of Cooperia curticei
McKellar, Quintin; Bogan, J. A.; Horspool, L.; Reid, K. (1988-04) -
Effect of meclofenamic acid on the response of parasite-naive lambs and adult sheep to Ostertagia circumcincta
Mitchell, E. S.; McKellar, Quintin; Bogan, J. A. (1990)Meclofenamic acid was used to inhibit prostaglandin synthesis in lambs challenged with Ostertagia circumcincta. It lowered the number of parasites which established in treated animals but not significantly. In treated ... -
Effect of Ostertagia ostertagi secretions and various putative secretagogues and inhibitors on aminopyrine accumulation in dispersed bovine abomasal gland cells
McKellar, Quintin; Mostofa, M.; Eckersall, P. D. (1990)Aminopyrine accumulation in suspensions of isolated gastric glands was used to determine the effect of Ostertagia ostertagi secretions and putative secretagogues and inhibitors on abomasal parietal cells. Parasite secretions ... -
Effect of parasitism with Nematodirus battus on the pharmacokinetics of levamisole, ivermectin and netobimin
McKellar, Quintin; Jackson, F.; Coop, R. L.; Jackson, E.; Scott, E. (1991-07)The pharmacokinetics of levamisole, ivermectin and netobimin administered orally and by subcutaneous injection were compared in lambs exposed to a moderate challenge with Nematodirus battus and in parasite naive lambs. ... -
Effect of probenecid on disposition kinetics of ampicillin in horses
Sarasola, P.; McKellar, Quintin (1992-08)The effect of an oral dose of probenecid on the disposition kinetics of ampicillin was determined in four horses. An intravenous bolus dose (10 mg/kg) of ampicillin sodium was administered to the horses on two occasions. ... -
The effect of sesame and sunflower oils on the plasma disposition of ivermectin in goats
Gokbulut, C.; Karademir, U.; Boyacioglu, M.; McKellar, Quintin (2008)The effect of sesame oil (SSO) and sunflower oil (SFO) (the excipients) on the plasma disposition of ivermectin (IVM) following intravenous (i.v.) and subcutaneous (s.c.) administration at a dosage of 200 μg/kg was ... -
Effect of sodium cromoglycate on the response to Ostertagia circumcincta in adult sheep
McKellar, Quintin; Bogan, J. A. (1987-09)Serum pepsinogen concentrations rose more rapidly and to higher levels in adult sheep infected with Ostertagia circumcincta and treated orally with the mast cell stabilising agent sodium cromoglycate than they did in adult ... -
The effects of different ages and dosages on the plasma disposition and hair concentration profile of ivermectin following pour-on administration in goats
Gokbulut, C.; Cirak, V. Y.; Senlik, B.; Aksit, D.; McKellar, Quintin (2011)The effects of different ages and dosages on the plasma disposition and hair degradation of ivermectin (IVM) were investigated following pour-on administration in goats. Twenty-eight female Saanen goats allocated into two ... -
The effects of excretions/secretions of Ostertagia circumcincta on ovine abomasal tissues in vitro
Scott, I.; McKellar, Quintin (1998-03)Products excreted/secreted by Ostertagia circumcincta stimulated the in vitro release of pepsinogen from intact abomasal mucosal sheets and caused the contraction of strips of abomasal smooth muscle, also in vitro. However, ... -
Effects of formulation concentration on intravenous pharmacokinetics, chirality and in vitro solubility of oxfendazole and its metabolites in sheep
Sanchez, S.F.; Jones, D. G.; Small, J.; McKellar, Quintin (2005)This study compared pharmacokinetic (PK) profiles in sheep dosed intravenously with three different concentrations of oxfendazole (OFZ). An in vitro plasma OFZ solubility study provided additional information on plasma ...