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Analysis of 'legal high' substances and common adulterants using handheld spectroscopic techniques
Assi, Sulaf; Guirguis, Amira; Halsey, S.; Fergus, S.; Stair, J. L. (2015-01)The identification of 'legal highs' is challenging as they often do not match their label claim and contain a wide range of impurities and/or adulterants. In addition, there is a need for techniques to be on-site, rapid ... -
Analysis of enquiries to the National Pharmacy Association following major changes to controlled drug legislation in the UK
Gallagher, C. T.; Hickman, A.C.; Hannbeck, L.; Flynn, R. W. (2012-02-01)Objectives The National Pharmacy Association (NPA) provides an advice service to community pharmacists in the UK, and keeps a database of the enquiries it receives. The aim of this research was to analyse the database for ... -
Analysis of histones from the yeast Saccharomyces carlsbergensis
Pastink, A.; Berkhout, Theo; Mager, W.H.; Planta, R.J. (1979-02)Basic chromosomal proteins were isolated from the chromatin of the yeast Saccharomyces carlsbergensis by extraction with H2SO4 and were purified by ion-exchange chromatography. Electrophoresis of the purified fraction on ... -
An analysis of the 'legal high' mephedrone
Gibbons, Simon; Zloh, Mire (2010)'Legal highs' are compounds, plant or fungal material which can be readily bought from the internet without legal restriction and the single chemicals may be structurally related to illegal drugs of abuse such as the ... -
Analysis of the data sources, numbers and characteristics of cocaine-related DRD cases reported in Special Mortality Registries, or eventually in General Mortality Registries (GMR) when necessary : A Report for the European Monitoring Centre for Drugs and Drug Addiction
Corkery, John (European Monitoring Centre for Drugs & Drugs Addiction, 2012-11-15)There have been increased numbers of cocaine-related deaths reported in some European countries since the early 1990s. There are indications that cocaine deaths are more difficult to define, detect and record as such in ... -
Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine
Hochfellner, C.; Evangelopoulos, D.; Zloh, Mire; Wube, A.; Guzman, J. D.; Mchugh, T. D.; Kunert, O.; Bhakta, S.; Bucar, F. (2015-04-01)The interaction of quinolone and indoloquinazoline alkaloids concerning their antimycobacterial activity was studied. Methods and Results: The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) ... -
Antibacterial acylphloroglucinols from Hypericum olympicum
Shiu, Winnie K. P.; Rahman, M. Mukhlesur; Curry, Jonathan; Stapleton, Paul; Zloh, Mire; Malkinson, John P.; Gibbons, Simon (2012)New antibacterial acylphloroglucinols (1-5) were isolated and characterized from the aerial parts of the plant Hypericum olympicum L. cf. uniflorum. The structures of these compounds were confirmed by extensive 1D- and ... -
The application and limitations of mathematical modelling in the prediction of permeability across mammalian skin and polydimethylsiloxane membranes
Moss, Gary; Sun, Yi; Wilkinson, Simon C.; Davey, N.; Adams, Roderick; Martin, Gary P.; Prapopopolou, M.; Brown, Marc (2011-11)Objectives: Predicting the rate of percutaneous absorption of a drug is an important issue with the increasing use of the skin as a means of moderating and controlling drug delivery. One key feature of this problem domain ... -
The application of discriminant analysis and Machine Learning methods as tools to identify and classify compounds with potential as transdermal enhancers
Moss, Gary; Shah, A.J.; Adams, R.G.; Davey, N.; Sun, Y.; Wilkinson, S.C.; Pugh, W.J. (2012-01-23)Discriminant analysis (DA) has previously been shown to allow the proposal of simple guidelines for the classification of 73 chemical enhancers of percutaneous absorption. Pugh et al. employed DA to classify such enhancers ... -
The application of feature selection to the development of Gaussian process models for percutaneous absorption.
Lam, L.T.; Sun, Yi; Davey, N.; Adams, Roderick; Prapopoulou, M.; Brown, Marc; Moss, Gary (2010)Objectives: The aim was to employ Gaussian processes to assess mathematically the nature of a skin permeability dataset and to employ these methods, particularly feature selection, to determine the key physicochemical ... -
The application of Gaussian processes in the prediction of absorption across mammalian skin and synthetic membranes
Sun, Y.; Prapopoulou, M.; Adams, R.; Davey, N.; Moss, G. P.; Brown, Marc (2010-06) -
The application of Gaussian processes in the prediction of percutaneous absorption
Moss, Gary P.; Sun, Yi; Prapopoulou, Maria; Davey, N.; Adams, Roderick; Pugh, W. John; Brown, Marc (2009-09)Objectives The aim was to assess mathematically the nature of a skin permeability dataset and to determine the utility of Gaussian processes in developing a predictive model for skin permeability, comparing it with existing ... -
The application of machine learning to the modelling of percutaneous absorption: An overview and guide
Ashrafi, P.; Moss, G. P.; Wilkinson, S. C.; Davey, N.; Sun, Yi (2015-03-18)Machine learning (ML) methods have been applied to the analysis of a range of biological systems. This paper reviews the application of these methods to the problem domain of skin permeability and addresses critically some ... -
The application of stochastic machine learning methods in the prediction of skin penetration
Sun, Y.; Brown, Marc; Prapopoulou, M.; Davey, N.; Adams, R. G.; Moss, G. P. (2011-03)Improving predictions of skin permeability is a significant problem for which mathematical solutions have been sought for around twenty years. However, the current approaches are limited by the nature of the models chosen ... -
Appropriateness of use of medicines in elderly inpatients: qualitative study
Spinewine, A.; Swine, C.; Dhillon, S.; Franklin, B.D.; Tulkens, P.M.; Wilmotte, L.; Lorant, V. (2005)Explores the processes leading to inappropriate use of medicines for elderly patients admitted for acute care. -
Arene-fused 1,2-oxazole N-oxides and derivatives. The impact of the N-O dipole and substitution on their aromatic character and reactivity profile. Can it be a useful structure in synthesis? A theoretical insight
Kozielewicz, Paweł; Tzeli, Demeter; Tsoungas, Petros G.; Zloh, Mire (2014-12-01)DFT calculations have shown that the N-O dipole of benzene- and naphthalene-fused 1,2-oxazole N-oxides causes a distortion of their σ and π frame, concentrated on the 1,2-oxazole ring, such that it increases its susceptibility ... -
Aromatic compounds from the liverwort Plagiochila spinulosa
Rycroft, D.S.; Srivastava, D.L.; Cole, W.J.; Ifeadike, P.; Kimbu, S.F.; Singh, J.; Connolly, J.D.; Thom, C.; Gerhard, U.; Organ, A.J.; Smith, R.J.; Hughes, M.; Harrison, L.J. (1999-04-10)Two known and five novel 9,10-dihydrophenanthrene derivatives, two orsellinic acid derivatives and a lunularic acid derivative have been isolated from the liverwort Plagiochila spinulosa and identified following NMR studies. ... -
Artificial selection of high proliferating and apoptosis-resistant NS0 cells for industrial production systems
Chau, D; Al-Rubeai, M (Springer Nature, 2004)It has been shown that the direct modification of metabolic networks by means of gene transfection or, genetic engineering, can cause unnecessary stresses and the metabolic overloading of cells. As a consequence, negative ... -
Aryl sulfones : A new class of γ-secretase inhibitors
Teall, M.; Oakley, P.; Harrison, T.; Shaw, D.; Kay, E.; Elliott, J.; Gerhard, U.; Castro, J.L.; Shearman, M.; Ball, R.G.; Tsou, N.N. (2005-05-16)The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described -
Aryldiketo acids have antibacterial activity against MDR Staphylococcus aureus strains : Structural insights based on similarity and molecular interaction fields
Drakulić, B.J.; Stavri, M.; Gibbons, S.; Žižak, Ž.S.; Verbić, T.Ž.; Juranić, I.O.; Zloh, Mire (2009-12-07)(Chemical Equation Presented) Similar structure=similar activity? The effect of substituents on the antibacterial activity of aryldiketo acids has been rationalised by molecular interaction fields and similarity studies ...