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Browsing by Author "Abou Shamat, Mohamad"
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A Design-of-Experiments Approach to Developing Thermoresponsive Gelators From Complex Polymer Mixtures
Kirton, Stewart; Stair, Jacqueline; Abou Shamat, Mohamad; Calvo-Castro, Jesus; Cook, Michael T. (2020-10-13)This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution ... -
Modifying the Properties of Thermogelling Poloxamer 407 Solutions through Covalent Modification and the Use of Polymer Additives
Abou Shamat, Mohamad; Calvo-Castro, Jesus; Stair, Jacqueline; Cook, Michael (2019-07-22)Thermoresponsive polymers that undergo sol–gel transition in a physiological temperature range have applications in biomedical science. Poloxamer 407 (P407) is commonly used as thermogelling material and has been approved ... -
Raman spectroscopy coupled to computational approaches towards understanding self-assembly in thermoreversible poloxamer gels
Cook, Michael T.; Abou Shamat, Mohamad; Stair, Jacqueline; Calvo-Castro, Jesus (2022-02-03)The exploitation of vibrational spectroscopy approaches towards the understanding of molecular-level events in polymers, such as poloxamers, is highly warranted. This would facilitate the development of real-time approaches ... -
Soluplus solutions as thermothickening materials for topical drug delivery.
Cook, Michael; Abou Shamat, Mohamad (2019-01-05)Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This ...