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Browsing by Author "Alva, Parimala"
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Cerebellar output controls generalized spike-and-wave discharge occurence
Kros, Lieke; Eelkman Rooda, Oscar; Spanke, Jochen; Alva, Parimala; van Dongen, Marijn; Karapatis, Athanasios; Tolner, Else; Strydis, Christos; Davey, N.; Winkelman, Beerend; Negrello, Mario; Serdijn, Wouter; Steuber, Volker; van den Maagdenberg, Arn; De Zeeuw, Chris I.; Hoebeek, Freek E. (2015-06-01)Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation ... -
Combining machine learning and simulations of a morphologically realistic model to study modulation of neuronal activity in cerebellar nuclei
Alva, Parimala; Kroos, Lieke; Eelkman Rooda, Oscar; De Zeeuw, Chris I.; Adams, R.G.; Davey, N.; Hoebeek, Freek E.; Steuber, Volker (2014-07-21)Epileptic absence seizures are characterized by synchronized oscillatory activity in the cerebral cortex that can be recorded as so-called spike-and-wave discharges (SWDs) by electroencephalogram. Although the cerebral ... -
Evolution of Dendritic Morphologies Using Deterministic and Nondeterministic Genotype to Phenotype Mapping
Alva, Parimala; De Sousa, Giseli; Torben-Nielsen, Ben; Maex, Reinoud; Adams, Roderick; Davey, N.; Steuber, Volker (Springer Nature, 2013)In this study, two morphological representations in the genotype, a deterministic and a nondeterministic representation, are compared when evolving a neuronal morphology for a pattern recognition task. The deterministic ... -
The Mining and Analysis of Data with Mixed Attribute Types
Wakelam, Ed; Davey, Neil; Sun, Yi; Jefferies, Amanda; Alva, Parimala; Hocking, Alex (IARIA, 2016-05-22)Mining and analysis of large data sets has become a major contributor to the exploitation of Artificial Intelligence in a wide range of real life challenges, including education, business intelligence and research. In the ... -
Optimization of input parameters to a CN neuron model to simulate its activity during and between epileptic absence seizures
Alva, Parimala; Kros, Lieke; Eelkman Rooda, Oscar; De Zeeuw, C.I.; Adams, Roderick; Davey, N.; Hoebeek, F.E.; Steuber, Volker (2015-12-04) -
A potential role for the cerebellar nuclei in absence seizures
Alva, Parimala; Kroos, Lieke; Maex, Reinoud; De Zeeuw, Chris I.; Adams, R.G.; Davey, N.; Steuber, Volker; Hoebeek, Freek E. (2013)Poster presented ar CNS 2013 -
Using Machine Learning and Computer Simulations to Analyse Neuronal Activity in the Cerebellar Nuclei During Absence Epilepsy
Alva, Parimala (2016-06-14)Absence epilepsy is a neurological disorder that commonly occurs in children. Some studies have shown that absence seizures predominantly originate either in the thalamus or the cerebral cortex. Some cerebellar nuclei (CN) ...