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Browsing by Author "Antonow, Dyeison"
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Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry
Heidelberger, Sibylle; Zinzalla, Giovanna; Antonow, Dyeison; Essex, Samantha; Piku Basu, B.; Palmer, Jonathan; Husby, Jarmila; Jackson, Paul J. M.; Rahman, Khondaker M.; Wilderspin, Andrew F.; Zloh, Mire; Thurston, David E. (2013-08-15)STAT3 (Signal Transducer and Activator of Transcription factor 3) is constitutively active in a wide range of human tumours. Stattic is one of the first non-peptidic small molecules reported to inhibit formation of the ... -
Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct : molecular basis for unexpectedly high DNA helix stabilization
Antonow, Dyeison; Barata, Teresa; Jenkins, Terence C.; Parkinson, Gary N.; Howard, Philip W.; Thurston, David E; Zloh, Mire (2008)The naturally occurring pyrrolo[2,1- c][1,4]benzodiazepine (PBD) monomers such as sibiromycin, anthramycin, and tomaymycin form stable covalent adducts with duplex DNA at purine-guanine-purine sites. A correlative relationship ... -
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents
Antonow, Dyeison; Kaliszczak, Maciej; Kang, Gyoung-Dong; Coffils, Marissa; Tiberghien, Arnaud C; Cooper, Nectaroula; Barata, Teresa; Heidelberger, Sibylle; James, Colin H; Zloh, Mire; Jenkins, Terence C; Reszka, Anthony P; Neidle, Stephen; Guichard, Sylvie M; Jodrell, Duncan I; Hartley, John A; Howard, Philip W; Thurston, David E (2010)A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding ...