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        Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents

        Author
        Antonow, Dyeison
        Kaliszczak, Maciej
        Kang, Gyoung-Dong
        Coffils, Marissa
        Tiberghien, Arnaud C
        Cooper, Nectaroula
        Barata, Teresa
        Heidelberger, Sibylle
        James, Colin H
        Zloh, Mire
        Jenkins, Terence C
        Reszka, Anthony P
        Neidle, Stephen
        Guichard, Sylvie M
        Jodrell, Duncan I
        Hartley, John A
        Howard, Philip W
        Thurston, David E
        Attention
        2299/10100
        Abstract
        A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding affinity. Both carbocyclic and heterocyclic C2-aryl substituents have been studied ranging from single aryl rings to fused ring systems, and also styryl substituents, establishing across a library of 80 analogues that C2-aryl and styryl substituents significantly enhance both DNA-binding affinity and in vitro cytotoxicity, with a correlation between the two. The optimal C2-grouping for both DNA-binding affinity and cytotoxicity was found to be the C2-quinolinyl moiety which, according to molecular modeling, is due to the overall fit of the molecule in the DNA minor groove, and potential specific contacts with functional groups in the floor and walls of the groove. This analogue (14l) was shown to delay tumor growth in a HCT-116 (bowel) human tumor xenograft model.
        Publication date
        2010
        Published in
        Journal of Medicinal Chemistry
        Published version
        https://doi.org/10.1021/jm901722v
        Other links
        http://hdl.handle.net/2299/10100
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