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dc.contributor.authorAntonow, Dyeison
dc.contributor.authorKaliszczak, Maciej
dc.contributor.authorKang, Gyoung-Dong
dc.contributor.authorCoffils, Marissa
dc.contributor.authorTiberghien, Arnaud C
dc.contributor.authorCooper, Nectaroula
dc.contributor.authorBarata, Teresa
dc.contributor.authorHeidelberger, Sibylle
dc.contributor.authorJames, Colin H
dc.contributor.authorZloh, Mire
dc.contributor.authorJenkins, Terence C
dc.contributor.authorReszka, Anthony P
dc.contributor.authorNeidle, Stephen
dc.contributor.authorGuichard, Sylvie M
dc.contributor.authorJodrell, Duncan I
dc.contributor.authorHartley, John A
dc.contributor.authorHoward, Philip W
dc.contributor.authorThurston, David E
dc.identifier.citationAntonow , D , Kaliszczak , M , Kang , G-D , Coffils , M , Tiberghien , A C , Cooper , N , Barata , T , Heidelberger , S , James , C H , Zloh , M , Jenkins , T C , Reszka , A P , Neidle , S , Guichard , S M , Jodrell , D I , Hartley , J A , Howard , P W & Thurston , D E 2010 , ' Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents ' , Journal of Medicinal Chemistry , vol. 53 , no. 7 , pp. 2927-41 .
dc.identifier.otherPURE: 1457502
dc.identifier.otherPURE UUID: 5c90da5b-de5e-464b-995f-68e27641c2ba
dc.identifier.otherPubMed: 20218628
dc.identifier.otherScopus: 77950584653
dc.description.abstractA comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding affinity. Both carbocyclic and heterocyclic C2-aryl substituents have been studied ranging from single aryl rings to fused ring systems, and also styryl substituents, establishing across a library of 80 analogues that C2-aryl and styryl substituents significantly enhance both DNA-binding affinity and in vitro cytotoxicity, with a correlation between the two. The optimal C2-grouping for both DNA-binding affinity and cytotoxicity was found to be the C2-quinolinyl moiety which, according to molecular modeling, is due to the overall fit of the molecule in the DNA minor groove, and potential specific contacts with functional groups in the floor and walls of the groove. This analogue (14l) was shown to delay tumor growth in a HCT-116 (bowel) human tumor xenograft model.en
dc.relation.ispartofJournal of Medicinal Chemistry
dc.titleStructure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agentsen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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