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Browsing by Author "Carpenter, Lewis"
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Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery : Combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds
Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick; Gough, Andrew; Devlin, Joe; Emery, Paul; Waterhouse, Lynn; James, David; Tate, Helen; Boys, Cathy; Williams, Peter; White, Dora; Dart, Helen; Winfield, John; Seymour, Annie; Williams, Richard; Blunn, Karina; McDowell, Jackie; Prouse, Peter; Andrews, Sheryl; Wilson, Deborah; Magliano, Malgorzata; Perks, Ursula; Coulson, Amanda; Hassle, Andrew; Kirwan, Michele; Leone, Francesca; Dunne, Ciaran; Hawley, Lindsey; Creamer, Paul; Taylor, Julie; Wilmott, Wendy; Knights, Sally; Rowland-Axe, Rebecca; Green, Sandra; Simmons, Dawn; David, Joel; Cox, Maureen; Bukhari, Marwan; Evans, Bronwen; Batley, Michael; Oram, Catherine; ERAS and ERAN (2016-11-10)Objectives: To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods: Health Assessment Questionnaire (HAQ) disability scores ... -
Can Early, Clinically Significant Radiographic Progression In The First Year Of Disease Predict Orthopaedic Surgery In Patients With Rheumatoid Arthritis?
Carpenter, Lewis; Jayakumar, Keeranur; Nikiphorou, Elena; Norton, Sam; Dixey, Josh; Young, Adam (2014-04)BACKGROUND: Orthopaedic intervention is an important outcome in Rheumatoid Arthritis (RA). The use of radiographic data in the early stages of the disease and its importance in determining future RA related outcomes is ... -
Do Interventions Designed to Support Shared Decision-Making Reduce Health Inequalities? : A Systematic Review and Meta-Analysis
Durand, Marie-Anne; Carpenter, Lewis; Dolan, Hayley; Bravo, Paulina; Mann, Mala; Bunn, Frances; Elwyn, Glyn (2014-04-15)Background: Increasing patient engagement in healthcare has become a health policy priority. However, there has been concern that promoting supported shared decision-making could increase health inequalities. Objective: ... -
Effect of magnesium supplementation on blood pressure : a meta-analysis
Kass, Lindsy; Weekes, J.; Carpenter, Lewis (2012)To date, there has been inconclusive evidence regarding the effect of magnesium supplements on blood pressure (BP). This meta-analysis was conducted to assess the effect of magnesium supplementation on BP and to establish ... -
Hand and foot surgery rates in rheumatoid arthritis have declined from 1986 to 2011, but large-joint replacement rates remain unchanged : results from two UK inception cohorts
Nikiphorou, Elena; Carpenter, Lewis; Morris, Stephen; MacGregor, Alex J.; Dixey, Josh; Kiely, P.; Norton, S.; James, David W.; Walsh, D.; Young, Adam (2014-04-28)To assess whether there have been any secular changes in orthopedic interventions in patients with rheumatoid arthritis (RA) since 1986, as examined in 2 early rheumatoid arthritis (RA) inception cohorts with up to 25 years ... -
Hands only illusion : Multisensory integration elicits sense of ownership for body parts but not for non-corporeal objects
Tsakiris, Manos; Carpenter, Lewis; James, Dafydd; Fotopoulou, Aikaterini (2010-07)The experience of body ownership can be successfully manipulated during the rubber hand illusion using synchronous multisensory stimulation. The hypothesis that multisensory integration is both a necessary and sufficient ... -
Have Radiographic Progression Rates in Early Rheumatoid Arthritis Changed? : A Systematic Review and Meta-analysis of Long-term Cohorts
Carpenter, Lewis; Nikiphorou, Elena; Sharpe, Rachel; Norton, Sam; Rennie, Kirsten; Bunn, Frances; Scott, David; Dixey, Josh; Young, Adam (2016-06-01)The objectives of this systematic review are to evaluate firstly, all published data on baseline and annual progression rates of radiographic damage from all longitudinal observational cohorts, and secondly, the association ... -
Importance of registries in informing clinical practice for arthritis
Carpenter, Lewis; Nikiphorou, Elena; Young, Adam (2013-11)The gold standard in research for evidence that underlies clinical practice is the randomized controlled trial. In recent years it has been accepted that observational studies, which include disease and drug registries and ... -
Long-Term Progression of Structural Joint Damage in Early Rheumatoid Arthritis
Carpenter, Lewis (2017-06-16)Rheumatoid Arthritis (RA) is a chronic auto-immune disease that causes in ammation in the joints. Left uncontrolled, this prolonged in ammation can lead to pain and structural damage, resulting in erosions to the bones ... -
Non-adherence to immunosuppressants following renal transplantation: a protocol for a systematic review
Hucker, Abigail; Bunn, Frances; Carpenter, Lewis; Lawrence, Christopher; Farrington, Kenneth; Sharma, Shivani (2017-09-28)Abstract Introduction Adherence to immunosuppressant medication is essential for renal transplant recipients. This review aims to summarise what is known about non-adherence, with a view to providing comprehensive evidence ... -
Osteoporotic fracture and post operative clinical and cost outcomes in rheumatoid arthritis (RA) : results from two UK inception cohorts
Nikiphorou, Elena; Carpenter, Lewis; Dixey, Josh; Williams, P.; Kiely, P.; Walsh, D; Williams, Richard; Young, Adam (2013-10)379: The risk of osteoporotic fracture is known to be high in RA. Yet less is known about RA related predictive factors for this complication & its associated economic burden -
Reductions in Radiographic Progression in Early Rheumatoid Arthritis Over Twenty-Five Years: : Changing Contribution From Rheumatoid Factor in Two Multicenter UK Inception Cohorts
Carpenter, Lewis; Norton, Sam; Nikiphorou, Elena; Jayakumar, Keeranur; McWilliams, Daniel F.; Rennie, Kirsten L.; Dixey, Josh; Kiely, Patrick; Walsh, David Andrew; Young, Adam; on behalf of the Early Rheumatoid Arthritis Study and the Early Rheumatoid Arthritis Network (2017-11-28)Objective: To assess the 5-year progression of erosions and joint space narrowing (JSN) and their associations with rheumatoid factor (RF) status in 2 large, multicenter, early rheumatoid arthritis cohorts, spanning 25 ... -
Remission vs low disease activity: function, quality of life and structural outcomes in the Early Rheumatoid Arthritis Study and Network
Nikiphorou, Elena; Norton, Sam; Carpenter, Lewis; Welsh, David; Creamer, Paul; Dixey, Josh; Young, Adam; Kiely, Patrick (2019-10-03)Objectives To examine associations between function, quality of life and structural outcomes in patients achieving remission vs low disease activity in early RA. Methods Demographic, clinical and radiographic variables ... -
Secular Changes in Clinical Features at Presentation of Rheumatoid Arthritis : Increase in Comorbidity But Improved Inflammatory States
Nikiphorou, Elena; Norton, Sam; Carpenter, Lewis; Dixey, Josh; Andrew Walsh, David; Kiely, Patrick; Young, Adam; on behalf of the Early Rheumatoid Arthritis Study and the Early Rheumatoid Arthritis Network Cohorts (2017-01-31)Objective: To examine secular trends in demographics, clinical manifestations, and comorbidity on first presentation of rheumatoid arthritis (RA) prior to disease-modifying antirheumatic drug treatment. Methods: A total ... -
Secular changes in the progression of clinical markers and patient-reported outcomes in early rheumatoid arthritis
Carpenter, Lewis; Nikiphorou, Elena; Kiely, Patrick D W; Walsh, David A; Young, Adam; Norton, Sam (2020-01-03)OBJECTIVES: To examine secular trends in the progression of clinical and patient-reported outcomes in early RA. METHODS: A total of 2701 patients recruited to the Early Rheumatoid Arthritis Study or Early Rheumatoid Arthritis ... -
The size, burden and cost of disorders of the brain in the UK
Fineberg, Naomi; Haddad, Peter M.; Carpenter, Lewis; Gannon, Brenda; Sharpe, Rachel; Young, Allan H.; Joyce, Eileen; Rowe, James; Wellsted, D.; Nutt, David J.; Sahakian, Barbara J. (2013-09)Aim: The aim of this paper is to increase awareness of the prevalence and cost of psychiatric and neurological disorders (brain disorders) in the UK. Method: UK data for 18 brain disorders were extracted from a systematic ... -
Validation of methods for converting the original Disease Activity Score (DAS) to the DAS28
Carpenter, Lewis; Norton, Sam; Nikiphorou, Elena; Kiely, Patrick; Walsh, David; Dixey, Josh; Young, Keith (2018-12-01)The Disease Activity Score (DAS) is integral in tailoring the clinical management of rheumatoid arthritis (RA) patients and is an important measure in clinical research. Different versions have been developed over the years ...