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Browsing by Author "Chau, David Y.S."
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Attachment of stem cells to scaffold particles for intra-cerebral transplantation
Bible, Ellen; Chau, David Y.S.; Alexander, Morgan R.; Price, Jack; Shakesheff, Kevin M.; Modo, Michel (2009)Cell-replacement therapy and tissue regeneration using stem cells are of great interest to recover histological damage caused by neuro-degenerative disease or traumatic insults to the brain. To date, the main intra-cerebral ... -
A biosynthetic bandage for corneal wound repair
Pratoomsoot, Chayanin; Hou, Qingpu; Chau, David Y.S.; Tanioka, H.; Hori, K.; Kawasaki, S.; Kinoshita, S.; Tighe, Patrick J.; Dua, Harminder; Shakesheff, Kevin M.; Rose, Felicity R. A. J. (2008-05) -
The cellular response to transglutaminase-cross-linked collagen
Chau, David Y.S.; Collighan, R.J.; Verderio, E.A.M.; Addy, V.L.; Griffin, M. (2005-11)Collagen, type 1, is a highly abundant natural protein material which has been cross-linked by 11 variety of methods including chemical agents, physical heating and UV irradiation with the aim of enhancing its physical ... -
Collagen: Structure and modification for biomedical applications
Chau, David Y.S.; Collighan, Russell J.; Griffin, Martin (Nova Science Publishers Inc., USA., 2007) -
Combination of Injectable Multiple Growth Factor-Releasing Scaffolds and Cell Therapy as an Advanced Modality to Enhance Tissue Neovascularization
Saif, Jaimy; Schwarz, Theresa M.; Chau, David Y.S.; Henstock, James; Sami, Paramjit; Leicht, Simon F.; Hermann, Patrick C.; Alcala, Sonia; Mulero, Francisca; Shakesheff, Kevin M.; Heeschen, Christopher; Aicher, Alexandra (2010-10)Objective-Vasculogenic progenitor cell therapy for ischemic diseases bears great potential but still requires further optimization for justifying its clinical application. Here, we investigated the effects of in vivo tissue ... -
Cross-linking of collagen I by tissue transglutaminase provides a promising biomaterial for promoting bone healing
Fortunati, Dario; Chau, David Y.S.; Wang, Zhuo; Collighan, Russell John; Griffin, Martin (2014-07)Transglutaminases (TGs) stabilize proteins by the formation of ε(γ-glutamyl)lysine cross-links. Here, we demonstrate that the cross-linking of collagen I (COL I) by tissue transglutaminase (TG2) causes an alteration in the ... -
The development of a 3D immunocompetent model of human skin
Chau, David Y.S.; Johnson, Claire; MacNeil, Sheila; Haycock, John W.; Ghaemmaghami, Amir M. (2013-09)As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from ... -
Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1
Hutter, Victoria; Chau, David Y.S.; Hilgendorf, Constanze; Brown, Alan; Cooper, Anne; Zann, Vanessa; Pritchard, David I.; Bosquillon, Cynthia (2014-01)The impact of P-glycoprotein (MDR1, ABCB1) on drug disposition in the lungs as well as its presence and activity in in vitro respiratory drug absorption models remain controversial to date. Hence, we characterised MDR1 ... -
The effect of delivery via narrow-bore needles on mesenchymal cells
Agashi, Kapil; Chau, David Y.S.; Shakesheff, Kevin M. (2009-01)Aims: Recently, there have been numerous preclinical and human studies investigating the regenerative capacity of cell suspensions following their direct injection into a target organ: the fundamental parameters for ... -
Improving treatment of stroke through nanotechnology
Nicholls, F; Gorenkova, N; Bible, Ellen; Franco, C; Chau, David Y.S.; Tolias, Christos; Shakesheff, Kevin; West, JL; Modo, Michel (CRC Press, 2013) -
In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine
Hou, Qingpu; Chau, David Y.S.; Pratoomsoot, Chayanin; Tighe, Patrick J.; Dua, Harminder S.; Shakesheff, Kevin M.; Rose, Felicity R. A. J. (2008-09)Aqueous solutions of blends of biodegradable triblock copolymers, composed of poly(DL-lactide-co-glycolide) (PLGA) and poly(ethylene glycol) (PEG) with varied D,L-lactide to glycolide ratios, displayed thermosensitivity ... -
In Vitro Cell Models for Ophthalmic Drug Development Applications
Shafaie, Sara; Hutter, Victoria; Cook, Michael T.; Brown, Marc; Chau, David Y.S. (2016-04-20)Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the ... -
Laminin and Fibronectin Treatment Leads to Generation of Dendritic Cells with Superior Endocytic Capacity
Garcia-Nieto, Samuel; Johal, Ramneek K.; Shakesheff, Kevin M.; Emara, Mohamed; Royer, Pierre-Joseph; Chau, David Y.S.; Shakib, Farouk; Ghaemmaghami, Amir M. (2010-04-19)Background: Sampling the microenvironment at sites of microbial exposure by dendritic cells ( DC) and their subsequent interaction with T cells in the paracortical area of lymph nodes are key events for initiating immune ... -
Life support systems for cell therapies
Agashi, K.; Chau, David Y.S.; Shakesheff, Kevin M. (2009) -
Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth
Jones, R. A.; Kotsakis, P.; Johnson, T. S.; Chau, David Y.S.; Ali, S.; Melino, G.; Griffin, M. (2006-09)Administration of active TG2 to two different in vitro angiogenesis assays resulted in the accumulation of a complex extracellular matrix (ECM) leading to the suppression of endothelial tube formation without causing cell ... -
Microparticles as tissue engineering scaffolds : manufacture, modification and manipulation
Chau, David Y.S.; Agashi, K.; Shakesheff, K. M. (2008-09)Tissue engineering, a field which focusses on the replacement, repair and regeneration of damaged or diseased tissue by the application of biomaterials, cells and associated biological molecules, has advanced rapidly due ... -
Neo-vascularization of the stroke cavity by implantation of human neural stem cells on VEGF-releasing PLGA microparticles
Bible, Ellen; Qutachi, Omar; Chau, David Y.S.; Alexander, Morgan R.; Shakesheff, Kevin M.; Modo, Michel (2012-10)Replacing the tissue lost after a stroke potentially provides a new neural substrate to promote recovery. However, significant neurobiological and biotechnological challenges need to be overcome to make this possibility ... -
A novel self-sintering microparticle-based system for regenerative medicine
Lee, S.Y.; Agashi, K.; Chau, David Y.S.; Shakesheff, Kevin M. (2008-07)The use of injectable scaffolds has raised great interest as they minimise the need for invasive surgery and its associated complications, costs and discomfort to the patient. Furthermore, they can fill cavities of any ... -
An Overview of Tissue Engineering as an Alternative for Toxicity Assessment
Garrod, Mathew; Chau, David Y.S. (2016-01-30)Tissue engineering is a multidisciplinary field that combines aspects of biology, material sciences, engineering and medicine - the ultimate goal being able to fabricate replacement tissues and/or organs for an ageing ... -
Severe conjunctivochalasis in association with classic type Ehlers-Danlos syndrome
Whitaker, John K.; Alexander, Philip; Chau, David Y.S.; Tint, Naing L. (2012-09-03)Background: Inferior conjunctivochalasis is common, but is rarely severe enough to require conjunctival excision. This report describes a patient with severe conjunctivochalasis who was subsequently diagnosed with Ehlers ...