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Browsing by Author "Cooper, Anne"
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Characterisation of ATP-binding cassette (ABC) transporters in the Calu-3 human bronchial epithelial cell culture model
Hutter, Victoria; Hilgendorf, Constanze; Brown, Alan; Cooper, Anne; Zann, Vanessa; Pritchard, David; Bosquillon, Cynthia (2010-10)Expression and functionality of ATP-binding cassette (ABC) transporters were assessed in Calu-3 cell monolayers cultured at an air-liquid interface. Transporter gene expression was in agreement with published data in human ... -
Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1
Hutter, Victoria; Chau, David Y.S.; Hilgendorf, Constanze; Brown, Alan; Cooper, Anne; Zann, Vanessa; Pritchard, David I.; Bosquillon, Cynthia (2014-01)The impact of P-glycoprotein (MDR1, ABCB1) on drug disposition in the lungs as well as its presence and activity in in vitro respiratory drug absorption models remain controversial to date. Hence, we characterised MDR1 ... -
Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates.
Hutter, Victoria; Hilgendorf, Constanze; Cooper, Anne; Zann, Vanessa; Pritchard, David; Bosquillon, Cynthia (2012-09-29)A rat respiratory epithelial cell culture system for in vitro prediction of drug pulmonary absorption is currently lacking. Such a model may however enhance the understanding of interspecies differences in inhaled drug ... -
Expression and functionality of P-glycoprotein in human bronchial epithelial cells in vitro
Hutter, Victoria; Hilgendorf, Constanze; Cooper, Anne; Zann, Vanessa; Pritchard, David; Bosquillon, Cynthia (2011-09)P-glycoprotein (P-gp) is expressed in normal tissues with barrier functions where it participates in cell defence mechanisms (Huls, M. et al. J Pharm Exp Ther 2009; 328:3-9). Its presence in the bronchial epithelium and ...