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Browsing by Author "Dailey, Lea Ann"
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Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis.
Bodhaniya, Aateka; Hoffman, Ewelina; Ball, Dough; Klapwijk, Jan; Steven, Rory T.; Dexter, Alex; Bunch, Josephine; Baker, Daniel; Murnane, Darragh; Hutter, Victoria; Page, Clive; Dailey, Lea Ann; Forbes, Ben (2019-07-17)‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally ... -
Dynamics of aerosol size during inhalation : Hygroscopic growth of commercial nebulizer formulations
Haddrell, Allen E.; Davies, James F.; Miles, Rachael E. H.; Reid, Jonathan P.; Dailey, Lea Ann; Murnane, Darragh (2014-03-10)The size of aerosol particles prior to, and during, inhalation influences the site of deposition within the lung. As such, a detailed understanding of the hygroscopic growth of an aerosol during inhalation is necessary to ... -
Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis
Dexter, Alex; Steven, Rory T; Patel, Aateka; Dailey, Lea Ann; Taylor, Adam J; Ball, Doug; Klapwijk, Jan; Forbes, Ben; Page, Clive P; Bunch, Josephine (2019-12)Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry ... -
Interface Engineering of Water-Dispersible Near-Infrared-Emitting CuInZnS/ZnSe/ZnS Quantum Dots
Mann, Patrick; Fairclough, Simon M.; Bourke, Struan; Burkitt Gray, Mary; Urbano, Laura; Morgan, David J.; Dailey, Lea Ann; Thanou, Maya; Long, Nicholas J.; Green, Mark A. (2024-07-18)We report the synthesis of near-infrared (IR)-emitting core/shell/shell quantum dots of CuInZnS/ZnSe/ZnS and their phase transfer to water. The intermediate ZnSe shell was added to inhibit the migration of ions from the ... -
Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis
Hoffman, Ewelina; Bodhaniya, Aateka; Ball, Doug; Klapwijk, Jan; Millar, Val; Kumar, Abhinav; Martin, Abigail; Mahendran, Rhamiya; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2017-12-31)Purpose. Progress to the clinic may be delayed or prevented when vacuolated or “foamy” alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods to study ... -
Nearly monodispersed, emission-tuneable conjugated polymer nanoparticles
Bourke, Struan; Urbano, Laura; Midson, Megan; Olona, Antoni; Basma Qazi-Choudhry, Basma; Panamarova, Maryna; Valderrama, Ferran; Long, Nicholas J.; Dailey, Lea Ann; Green, Mark (2022-10-04)Conjugated polymer nanoparticles have shown great promise in biological imaging due to their stable optical properties and inert composition but are usually polydispersed. By encapsulating conjugated polymer CN-PPV with a ... -
Profiling alveolar macrophage responses to inhaled compounds using in vitro high content image analysis
Hoffman, Ewelina; Urbano, Laura; Martin, Abigail; Mahendran, Rhamiya; Patel, Aateka; Murnane, Darragh; Page, Clive; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2023-09-01)One of the main hurdles in the development of new inhaled medicines is the frequent observation of foamy macrophage (FM) responses in non-clinical studies in experimental animals, which raises safety concerns and hinders ... -
Theranostic NIR-active Conjugated Polymer Nanoparticles
Zhao, Miao; Leggett, Edward; Bourke, Struan; Poursanidou, Souzana; Carter-Searjeant, Sadie; Po, Steve; Palma do Carmo, Marciano; Dailey, Lea Ann; Manning, Philip; Ryan, Sean; Urbano, Laura; Green, Mark; Rakovich, Aliaksandra (2021-05-12)Conjugated polymer nanoparticles (CPNs) based on a common solar cell material (PTB7) have been prepared, and their potential in theranostic applications based on bioimaging and photosensitizing capabilities has been ... -
Thermal Lens Spectrometry Reveals Thermo-Optical Property Tuning of Conjugated Polymer Nanoparticles Prepared by Microfluidics
Abelha, Thais; Calvo-Castro, Jesus; Lima, Sandro; Reis Silva, Junior; Andrade, Luis; de Mello, John C.; Dreiss, C. A.; Green, Mark; Dailey, Lea Ann (2022-07-18)Conjugated polymers display useful thermo-optical properties of high relevance to biomedical applications, which are not only dependent on their intrinsic chemical composition but also related to their physical conformation ...