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Browsing by Author "Diabetic neuropathies"
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Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway
Deng, L.; Hu, S.; Baydoun, A. R.; Chen, J.; Chen, X.; Cong, X. (2009)Background and Objectives: Mesenchymal stem cells (MSC) are multipotent progenitor cells that are have found use in regenerative medicine. We have previously observed that aspirin, a widely used anti-inflammatory drug, ... -
Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation : implications for a clinical test
Kirkby, Nick; Chan, M.V.; Lundberg, M.H.; MacKenzie, Louise; Leadbeater, Phillip D.M.; Milne, Ginger L.; Potter, Claire M.; Al-Yamani, Malak; Adeyemi, Oladipupo; Warner, Tim D.; Mitchell, Jane A. (2013-10)Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin ... -
Cell Culture Techniques
Baydoun, A. R.; Wilson, Keith; Walker, John; Health & Human Sciences Research Institute; School of Life and Medical Sciences; Department of Human and Environmental Sciences; Pharmacology and Clinical Science Research; Cardiovascular Pathologies; Diabetic neuropathies; Biochemistry and Bioinformatics (Cambridge University Press, 2010-03)This best-selling undergraduate textbook provides an introduction to key experimental techniques from across the biosciences. It uniquely integrates the theories and practices that drive the fields of biology and medicine, ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (MDPI Multidisciplinary Digital Publishing Institute, 2022-05-01)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role ... -
Contribution of COX1 and COX2 to prostacyclin release by healthy mouse tissues
Kirkby, N.S.; Harrington, Louise; Lundberg, Martina; Hoefer, T.; Warner, Tim D.; Mitchell, Jane A. (2011-06) -
Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function
Bucci, M.; Vellecco, V.; Brancaleone, V.; Roviezzo, F.; Mattace Raso, G.; Ianaro, A.; Meli, R.; Cirino, G.; Harrington, L.; Lungarella, G.; De Palma, R. (2013)Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR and TLR4 in ... -
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
Kirkby, N.S.; Lundberg, M.H.; Harrington, L.S.; Leadbeater, P.D.M.; Potter, C.M.F.; Al-Yamani, M.; Adeyemi, O.; Mitchell, J.A.; Warner, T.D.; Milne, G.L. (2012-10-23)Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production ... -
Dexamethasone selectivity inhibits induction of nitric oxide synthase, but not induction of L-arginine transport, in activated murine macrophage J774 cells
Bogle, R.G.; Baydoun, A. R.; Pearson, J.D.; Mann, G.E. (1994) -
The ‘EDHF’ Antagonist 14, 15 Epoxyeicosa-5(Z)-Enoic Acid has Vasodilator Properties in Mesenteric Vessels
MacKenzie, Louise Susan; Falck, John R.; Mitchell, Jane A. (2004-07)There is now overwhelming evidence for Epoxyeicosatrienoic acids (EETs) as endothelial derived hyperpolarising factor (EDHF). Most recently, a number of pharmacological tools have been developed for the study of EETs in ... -
Effects of Apamin and Charybdtoxin on Endothelium Independent Vasodilatation : Implications in the study of EDHF
MacKenzie, Louise Susan; Carrier, M.J.; Mitchell, J.A. (2005-12)Endothelial derived hyperpolarizing factor (EDHF), together with endothelial derived NO and prostacyclin represent the major endogenous vasodilator hormone pathways (Coleman et al, 2004). Since the chemical nature of EDHF ... -
Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists
Zloh, Mire; Perez Diaz, Noelia; Tang, Leslie; Patel, Pryank; MacKenzie, Louise Susan (2016-02-01)Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen ... -
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sarah; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-02-17)BACKGROUND: Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased ... -
G-quadruplex formation of FXYD1 pre-mRNA indicates the possiblity of regulating expression of its protein product
Dhayan, Hansraj; Baydoun, A. R.; Kukol, A. (2014-10-15)G-quadruplexes are higher-order nucleic acid structures formed of square-planar arrangements of four guanine bases held together by Hoogsteen-type hydrogen bonds. Stacks of guanine tetrads are stabilised by intercalating ... -
Harnessing the benefits of PPARβ/δ agonists
MacKenzie, Louise Susan; Lione, Lisa (2013-12)Lipid mediators have complex effects on the cell; one of the key transcriptional factors that moderate proliferation and inflammatory effects is PPARβ/δ. Following highly successful clinical trials using the PPARβ/δ agonists ... -
Human uraemic serum displays calcific potential in vitro that increases with advancing chronic kidney disease
Patidar, Ashish; Singh, Dhruv; Winocour, Peter; Farrington, Ken; Baydoun, A. R. (2013-03)Vascular calcification strongly correlates with declining renal function and contributes to the high morbidity and mortality of patients with chronic kidney disease (CKD). It is closely regulated by circulating factors but ... -
A hyperspectral fluorescence lifetime probe for skin cancer diagnosis
De Beule, P A A; Dunsby, C; Galletly, N P; Stamp, G W; Chu, A C; Anand, U; Anand, P; Benham, C.D.; Naylor, A; French, P M W (2007)The autofluorescence of biological tissue can be exploited for the detection and diagnosis of disease but, to date, its complex nature and relatively weak signal levels have impeded its widespread application in biology ... -
In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone beta receptor antagonist properties.
Perez Diaz, Noelia; Zloh, Mire; Patel, Pryank; MacKenzie, Louise Susan (2016-01-01)Prostacyclin (PGI2) is a key mediator involved in cardiovascular homeostasis, acting predominantly on two receptor types; cell surface IP receptor and cytosolic peroxisome proliferator activated receptor (PPAR) β/δ. Having ... -
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
Kirkby, N.S.; Zaiss, A.K.; Urquhart, P.; Jiao, J.; Austin, P.J.; Al-Yamani, Malak; Lundberg, M.H.; MacKenzie, Louise; Warner, T.D.; Nicolaou, A.; Herschman, H.R.; Mitchell, J.A. (2013-07-09)There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ... -
Linking Induction and Transrepression of PPARβ/δ with Cellular Function
Perez Diaz, Noelia; MacKenzie, Louise Susan (2015-01-26)Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear hormone receptor superfamily. PPARβ/δ is ubiquitously expressed and has a central role in homeostasis, ... -
Linking Phospholipase C isoforms with differentiation function in human vascular smooth muscle cells
MacKenzie, Louise Susan; Lymn, Joanne; Hughes, Alun D. (2013-12)The phosphoinositol phospholipase C (PLC) family of enzymes consists of a number of isoforms, each of which has different cellular functions. PLCγ1 is primarily linked to tyrosine kinase transduction pathways, whereas PLCδ1 ...