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Browsing by Author "Errington, Rachel J."
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Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells
Errington, Rachel J.; Ameer-Beg, S. M.; Vojnovic, B.; Patterson, Laurence H.; Zloh, Mire; Smith, P. J. (2005)Many anticancer drugs require interaction with DNA or chromatin components of tumor cells to achieve therapeutic activity. Quantification and exploration of drug targeting dynamics can be highly informative in the rational ... -
Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions
Malkinson, John P.; Zloh, Mire; Kadom, Mohanad; Errington, Rachel J.; Smith, Paul J.; Searcey, Mark (2003)The first solid-phase synthesis of the chlorofusin peptide is described. The synthesis involved side-chain immobilization of N(alpha)-Fmoc-Asp-ODmab. Synthesis of the linear peptide, initially incorporating racemic Ade8 ... -
Spectral analysis of the DNA targeting bisalkylaminoanthraquinone DRAQ5 in intact living cells
Njoh, Kerenza L.; Patterson, Laurence H.; Zloh, Mire; Wiltshire, Marie; Fisher, Janet; Chappell, Sally; Ameer-Beg, Simon; Bai, Yanhong; Matthews, Daniel; Errington, Rachel J.; Smith, Paul J. (2006-08)We report on the potential DNA binding modes and spectral characteristics of the cell-permeant far red fluorescent DNA dye, DRAQ5, in solution and bound within intact cells. Our aim was to determine the constraints for its ...