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Browsing by Author "Evans, M.L."
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Calcium Efflux mechanisms following depolarisation evoked calcium transients in cultured rat sensory neurones
Benham, C.D.; Evans, M.L.; McBain, C.J. (1992) -
Calcium influx stimulated by activation of ATP receptors on sensory neurons from rat dorsal root ganglia
Bouvier, M.M.; Evans, M.L.; Benham, C.D. (1991)A combination of microspectrofluorimetry and single cell voltage-clamp was used to examine the response to ATP of cultured neurons from rat dorsal root ganglia. ATP activated an inward current and a rise in internal calcium ... -
Caspase inhibitors are functionally neuroprotective against oxygen glucose deprivation induced CA1 death in organotypic hippocampal slices
Ray, A.; Owen, D.; Evans, M.L.; Davis, J.B.; Benham, C.D. (2000)We have explored the neuroprotective efficacy of the cell penetrant caspase inhibitor, Ac-YVAD-cmk, in a hippocampal slice model of neuronal cell death induced by oxygen and glucose deprivation. Organotypic hippocampal ... -
Changes in cytoplasmic calcium induced by purinergic P2X receptor activation in vascular smooth muscle cells and sensory neurons
Benham, C.D.; Bouvier, M.M.; Evans, M.L. (1991) -
The effects of SB 206284A, a novel neuronal Ca channel antagonist in models of cerebral ischaemia
Wood, N.; Barone, F.C.; Benham, C.D.; Brown, T.H.; Campbell, C.A.; Cooper, D.C.; Evans, M.L.; Feuerstein, G.; Hamilton, T.C.; Harries, M.; King, P.D.; Meakin, J.E.; Murkitt, J.L.; Patel, S.; Price, W.J.; Roberts, J.C.; Rothaul, A.L.; Samson, N.A.; Smith, S.J.; Hunter, A.J. (1997)The effects of SB 206284A, 1-[7-(4-benzyloxyphenoxy)heptyl] piperidine hydrochloride, have been investigated in vitro on calcium and sodium currents in rat-cultured dorsal root ganglion (DRG) neurones and potassium-mediated ... -
Lack of effect of the novel anticonvulsant SB 204269 on voltage dependent currents in neurones cultured from rat hippocampus
Caesar, M.; Evans, M.L.; Benham, C.D. (1999)The novel anticonvulsant SB-204269 inhibits epileptiform afterdischarges induced by high K+ in rat hippocampal slices. Its effects on voltage-gated Na+ currents, measured from cultured hippocampal neurones using whole cell ... -
Orexin-A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J.J.; Leslie, R.A.; Patel, S.; Evans, M.L.; Wattam, T.A.; Holmes, S.; Benham, C.D.; Taylor, S.G.; Routledge, C.; Hemmati, P.; Munton, R.P.; Ashmeade, T.E.; Shah, A.S.; Hatcher, J.P.; Hatcher, P.D.; Jones, D.N.C.; Smith, M.I.; Piper, D.C.; Hunter, A.J.; Porter, R.A.; Upton, N. (1999) -
SB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemia
Benham, C.D.; Brown, T.H.; Cooper, D.C.; Evans, M.L.; Harries, M.; Herdon, H.J.; Meakin, J.E.; Murkitt, K.L.; Patel, S.; Roberts, J.C.; Rothaul, A.L.; Smith, S.J.; Wood, N.; Hunter, A.J. (1993)We have characterised the Ca2+ channel blocking properties of a new non-peptide Ca2+ channel antagonist, SB 201823-A, in cultures of rat sensory neurones. The IC50 for SB 201823-A against total Ca2+ current in sensory ... -
SB-334867-A antagonises orexin mediated excitation in the locus coeruleus
Soffin, E.M.; Evans, M.L.; Gill, C.H.; Harries, M.; Benham, C.D.; Davies, C.H. (2002)Electrophysiological recordings from identified noradrenergic locus coeruleus (LC) neurones in rat brain slices have revealed that the orexins can cause direct and reversible depolarisation of the postsynaptic membrane. ...