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All patients receiving renal replacement therapy in the United Kingdom in 2005 (chapter 4)
Farrington, Ken; Rao, R.; Stenkamp, R.; Ansell, D.; Feest, T. (2007)Summary data are provided for the whole United Kingdom. There were 41 776 adult patients alive on renal replacement therapy (RRT) in the UK at the end of 2005, a prevalence for adults of 694 pmp. Addition of 748 children ... -
Analytical quality goals for parathyroid hormone based on biological variation
Viljoen, A.; Singh, D.K.; Twomey, P.J.; Farrington, Ken (2008)Background: Measurement of parathyroid hormone (PTH) is central in the investigation of pathologies of bone and mineral ion metabolism. Knowledge of the biological variation of an analyte forms an essential part of evaluating ... -
Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis
Jolly, Elaine C; Clatworthy, Menna R; Lawrence, Christopher; Nathan, Paul D; Farrington, Ken (2009-04-28)Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, ... -
Aortoiliac arteriovenous fistula masquerading as deep vein thrombosis
Jolly, E.C.; Alaeddin, F.; Farrington, Ken (2008)A male smoker in his 60s with hypertension and hyperlipidaemia presented with progressive swelling of his left leg, abdominal discomfort and oliguria. He was obese and had an extensive left deep vein thrombosis (DVT) ... -
Approaches to the identification and management of depression in people living with chronic kidney disease: A scoping review of 860 papers
Pearce, Christina J.; Hall, Natalie; Hudson, Joanna L.; Farrington, Ken; Tucker, Madeleine J. Ryan; Wellsted, David; Jones, Julia; Sharma, Shivani; Norton, Sam; Ormandy, Paula; Palmer, Nick; Quinnell, Anthony; Fitzgerald, Lauren; Griffiths, Sophie; Chilcot, Joseph (2023-01-16)Background: Depression is prevalent across the spectrum of Chronic Kidney Disease and associated with poorer outcomes. There is limited evidence regarding the most effective interventions and care pathways for depression ... -
Are low erythropoietin and 1,25-dihydroxyvitamin D levels indicative of tubulo-interstitial dysfunction in diabetes without persistent microalbuminuria?
Singh, D.K.; Winocour, P.; Summerhayes, B.; Viljoen, A.; Sivakumar, G.; Farrington, Ken (2009)Aims: To investigate the relationship between Erythropoietin (EPO) and 1,25-dihydroxyvitamin D levels, and tubular damage in patients with diabetes mellitus (DM) without persistent microalbuminuria. Methods: We measured ... -
An association between depressive symptoms and survival in incident dialysis patients
Chilcot, Joseph; Davenport, Andrew; Wellsted, D.; Firth, John; Farrington, Ken (2011)Depression in end-stage renal disease patients is detrimental to quality of life, and is also associated with adverse clinical outcomes. The aim of this study was to examine whether depression symptoms in 'incident dialysis' ... -
An Association between Residual Renal Function and Depression Symptoms in Haemodialysis Patients
Chilcot, J.; Wellsted, D.; Vilar, Enric; Farrington, Ken (2009)Background: The loss of residual renal function (RRF) and subsequent urine volume among haemodialysis (HD) patients may influence affect. Although RRF has been associated with improved patient outcome, its relationship ... -
“Benign” hypergammaglobulinemic purpura is not benign in pregnancy
Jolly, E.C.; Hunt, B.J.; Ellis, S.; Griffiths, M.; Farrington, Ken (2009)A woman presented at 25 weeks gestation in her first pregnancy with severe preeclampsia and an intrauterine death. It later emerged that she had Waldenstrom’s benign hypergammaglobulinemic purpura. We discuss the implications ... -
Beta-glucans in advanced CKD : role in endotoxaemia and inflammation
Wong, Jonathan; Zhang, Yonglong; Swift, Oscar; Finkelman, Malcolm; Patidar, Ashish; Ramanarayanan, Sivaramakrishnan; Vilar, Enric; Farrington, Ken (2020-04-06)BACKGROUND/AIMS: (1-3)-β-D glucans (BG) are cellular components of yeasts and fungi. Elevated blood levels may be an adjunct in diagnosing invasive fungal infection, though can be high in dialysis patients without fungaemia. ... -
Broadening options for long-term dialysis in the elderly (BOLDE) : differences in quality of life on peritoneal dialysis compared to haemodialysis for older patients
Brown, E.A.; Johansson, L.; Farrington, Ken; Gallagher, H.; Sensky, T.; Gordon, F.; Da Silva Gane, M.; Beckett, N.; Hickson, M. (2010)Background. Health-related quality of life (QOL) is an important outcome for older people who are often on dialysis for life. Little is, however, known about differences in QOL on haemodialysis (HD) and peritoneal dialysis ... -
Characteristics of Frailty in Haemodialysis Patients
Hendra, Heidy; Sridharan, Sivakumar; Farrington, Ken; Davenport, Andrew (2022-05-06)Background: Both frailty and cachexia increase mortality in haemodialysis (HD) patients. The clinical frailty score (CFS) is a seven-point scale and less complex than other cachexia and frailty assessments. We wished to ... -
Choosing not to dialyse : evaluation of planned non-dialytic management in a cohort of patients with end-stage renal failure
Smith, C.; Da Silva-Gane, M.; Chandna, S.; Warwicker, P.; Greenwood, R.; Farrington, Ken (2003-10-31)OBJECTIVES: To study factors influencing the recommendation for palliative (non-dialytic) treatment in patients approaching end-stage renal failure and to study the subsequent outcome in patients choosing not to dialyse. ... -
Choosing Not to Take Phosphate Binders : The Role of Dialysis Patients' Medication Beliefs
Wileman, Vari; Chilcot, Joseph; Norton, Sam; Hughes, Lyndsay; Wellsted, D.; Farrington, Ken (2011)Objective: Patients with end-stage renal disease (ESRD) receiving haemodialysis are at risk of cardiovascular disease and bone disorders related to high levels of serum phosphate (PO(4)). Phosphate binders are an important ... -
Cognitive-behavioural therapy (CBT) for renal fatigue (BReF) : a feasibility randomised-controlled trial of CBT for the management of fatigue in haemodialysis (HD) patients
Picariello, Federica; Moss-Morris, Rona; Macdougall, Iain C; Norton, Sam; Da Silva-Gane, Maria; Farrington, Ken; Clayton, Hope; Chilcot, Joseph (2018-03-01)INTRODUCTION: Fatigue is one of the most common and disabling symptoms in end-stage kidney disease, particularly among in-centre haemodialysis patients. This two-arm parallel group feasibility randomised controlled trial ... -
Communication as care at end of life : An emerging issue from an exploratory action research study of renal end-of-life care for ethnic minorities in the UK
Wilkinson, Emma K.; Randhawa, Gurch; Brown, Edwina Anne; Da Silva Gane, Maria; Stoves, John; Warwick, Graham L.; Akhtar, Tahira; Magee, Regina; Sharman, Sue; Farrington, Ken (2014-09)South Asian people have a higher risk of developing kidney disease, are disproportionately represented in the patient population requiring renal replacement therapy and wait longer to receive a kidney transplant, compared ... -
Conservative care for ESRD in the United Kingdom : a national survey
Okamoto, Ikumi; Tonkin-Crine, Sarah; Rayner, Hugh; Murtagh, Fliss E M; Farrington, Ken; Caskey, Fergus; Tomson, Charles; Loud, Fiona; Greenwood, Roger; O'Donoghue, Donal J; Roderick, Paul (2015-01-07)BACKGROUND AND OBJECTIVES: Conservative kidney management (CKM) has been developed in the United Kingdom (UK) as an alternative to dialysis for older patients with stage 5 CKD (CKD5) and multiple comorbidities. This national ... -
Criteria for and Appropriateness of Renal Transplantation in Elderly Patients With End-Stage Renal Disease : A Literature Review and Position Statement on Behalf of the European Renal Association-European Dialysis and Transplant Association Descartes Working Group and European Renal Best Practice
Segall, Liviu; Nistor, Ionuţ; Pascual, Julio; Mucsi, Istvan; Guirado, Lluis; Higgins, Robert; Van Laecke, Steven; Oberbauer, Rainer; Van Biesen, Wim; Abramowicz, Daniel; Gavrilovici, Cristina; Farrington, Ken; Covic, Adrian (2016-10-01)During the last 20 years, waiting lists for renal transplantation (RT) have grown significantly older. However, elderly patients (ie ≥65 years of age) are still more rarely referred or accepted to waiting lists and, if ... -
Depression and clinical outcomes in CKD: do anti-depressants play a role? (EQUAL study)
Chilcot, Joseph; Picariello, Federica; Farrington, Ken (2022-08-01) -
Depression in End-Stage Renal Disease : Current Advances and Research
Chilcot, J.; Wellsted, D.; Farrington, Ken (2010)Depression or the presence of significant depressive symptoms remains common in patients with end-stage renal disease (ESRD). It is thought that 20–30% of ESRD patients have significant depressive symptoms, although there ...