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Browsing by Author "Gajjar, Parmesh"
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Crystallographic tomography and molecular modelling of structured organic polycrystalline powders
Gajjar, Parmesh; Nguyen, Thai T. H.; Sun, Jun; Styliari, Ioanna D.; Bale, Hrishikesh; McDonald, Samuel A.; Burnett, Timothy L.; Tordoff, Benjamin; Lauridsen, Erik; Hammond, Robert B.; Murnane, Darragh; Withers, Philip J.; Roberts, Kevin J. (2021-03-02)A fundamental understanding of the behaviour of polycrystalline materials, including pharmaceuticals, is vital for control of their physicochemical and crystalline properties, which in turn has the potential to improve ... -
Microstructural insight into inhalation powder blends through correlative multi-scale X-ray Computed Tomography
Gajjar, Parmesh; Styliari, Ioanna Danai; Legh-Land, Victoria; Bale, Hrishikesh; Tordoff, Benjamin; Withers, Philip; Murnane, Darragh (2023-10-30)Dry powder inhalers (DPI) are important for topical drug delivery to the lungs, but characterising the pre-aerosolised powder microstructure is a key initial step in understanding the post-aerosolised blend performance. ... -
Multiscale Tomography: Probing The Nano-, Micro-, And Meso-Scale Resolution Of Inhalation Powder Structure
Gajjar, Parmesh; Styliari, Ioanna Danai; Burnett, Timothy; Chen, Xizhong; Elliot, James A.; Ganley, William J.; Hammond, Robbert; Nguyen, Hien; Price, Robert; Roberts, Kevin; Withers, Philip; Murnane, Darragh (Respiratory Drug Delivery, RDD, 2019-05-07)Understanding the agglomeration behavior of inhaled formulations is essential to ensure consistent aerosolization performance that maximizes drug deposition in the lower respiratory tract. Although many techniques are ... -
On Measuring the Specific Surface Area of inhalation-grade lactose powders
Styliari, Ioanna Danai; Nguyen, Thai TH; Gajjar, Parmesh; Tordoff, Benjamin; Burnett, Timothy; Withers, Philip; Hammond, Robert B.; Roberts, Kevin J.; Murnane, Darragh (2020-01-28) -
Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α‑Lactose Monohydrate
Ma, Cai Y.; Nguyen, Thai T. H.; Gajjar, Parmesh; Styliari, Ioanna D.; Hammond, Robert B.; Withers, Philip J.; Murnane, Darragh; Roberts, Kevin J. (2023-09-08)Grid-based systematic search methods are used to investigate molecule–molecule, molecule–surface, and surface–surface contributions to interparticle interactions in order to identify the crystal faces that most strongly ... -
Understanding the agglomerate crystallisation of hexamine through X-ray microscopy and crystallographic modelling
Nguyen, Thai T.H.; Gajjar, Parmesh; Sun, Jun; Hammond, Robert B.; Murnane, Darragh; Tordoff, Benjamin; Lauridsen, Erik; Withers, Philip J.; Roberts, Kevin J. (2023-02-01)The detailed molecular-scale mechanism of the growth of organic crystals underpins a diversity of phenomena, such as the isolation and purification of high-quality materials for the pharmaceutical and fine chemical sectors. ... -
Unlocking the Microstructure of Inhalation Blends using X-ray Microscopy
Gajjar, Parmesh; Bale, Hrishikesh; Burnett, Timothy; Chen, Xizhong; Elliot, James A.; Gomez, Herminso Villarraga; Hammond, Robert B.; Nguyen, Hien; Roberts, Kevin J.; Styliari, Ioanna Danai; Tordoff, Benjamin; Withers, Philip; Murnane, Darragh (Respiratory Drug Delivery, RDD, 2020-04-26)Microstructural equivalence (Q3) for dry powder inhalers (DPIs) is complex because it involves both pre- and post-aerosolization powders and can be influenced by the DPI device and the patient’s aerosolization efficiency. In ...