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Browsing by Author "Gue, Ying X."
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Angiotensin Converting Enzyme 2 may mediate disease severity in COVID-19
Gue, Ying X.; Kanji, Rahim; Gorog, Diana (2020-06-09)Identification of vulnerability to severe coronavirus disease 2019 (COVID-19) is extremely important and might allow optimised shielding and easing of lockdown. The disease is attributed to the severe acute respiratory ... -
Antithrombotic in atrial fibrillation and coronary artery disease – Does less mean more?
Gue, Ying X.; Gorog, Diana; Lip, Gregory Y H (2022-06-15)In the treatment of patients with chronic coronary syndrome, the use of antiplatelets in the form of aspirin is a class 1 indication in the prevention of future thrombotic events.1 Similarly, oral anticoagulation (OAC) has ... -
Apixaban Enhances Endogenous Fibrinolysis in Patients with Atrial Fibrillation
Spinthakis, Nikolaos; Gue, Ying X.; Farag, Mohamed; Srinivasan, Manivannan; Wellsted, David; Lip, Gregory Y H; Arachchillage, Deepa RJ; Gorog, Diana (2019-09-01)AIMS: Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which strongly relates to improved functional outcome. The impact of oral anticoagulants ... -
Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: An European and Asia-Pacific Expert Consensus Paper
Gorog, Diana; Gue, Ying X.; Chao, Tze-Fan; Fauchier, Laurent; Ferreiro, Jose Luis; Huber, Kurt; Konstantinidis, Stavros V; Lane, Deirdre A; Marin, Francisco; Oldgren, Jonas; Potpara, Tatjana; Roldan, Vanessa; Rubboli, Andrea; Sibbing, Dirk; Tse, Hung-Fat; Vilahur, Gemma; Lip, Gregory Y H (2022-03-22)Whilst there is a clear clinical benefit of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and venous thromboembolism (VTE) in reducing the risks of thromboembolism, major bleeding events (especially ... -
Assessment of endogenous fibrinolysis in clinical using novel tests - Ready for clinical roll-out?
Gue, Ying X.; Ding, Wern Yew; Lip, Gregory Y H; Gorog, Diana (2021-04-01)The occurrence of thrombotic complications, which can result in excess mortality and morbidity, represent an imbalance between the pro-thrombotic and fibrinolytic equilibrium.The mainstay treatment of these complications ... -
Biomarkers of Thrombotic Status Predict Spontaneous Reperfusion in Patients With ST-Segment Elevation Myocardial Infarction
Kanji, Rahim; Gue, Ying X.; Memtsas, Vassilios; Spencer, Neil H.; Gorog, Diana (2023-05-16)Background Spontaneous reperfusion, seen in ∼20% of patients with ST-segment elevation myocardial infarction (STEMI), manifests as normal epicardial flow in the infarct-related artery, with or without ST-segment resolution, ... -
A case of repetitive myocardial infarction with unobstructed coronaries due to Churg-Strauss syndrome
Gue, Ying X.; Prasad, Sanjay; Isenberg, David; Gorog, Diana A. (2019-06-01)BackgroundMyocardial infarction is most commonly caused by thrombosis occurring on a background of coronary atherosclerosis, resulting in reduced coronary flow. Less often, myocardial infarction can occur in the absence ... -
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction
Kanji, Rahim; Gue, Ying X.; Farag, Mohamed F.; Spencer, Neil H.; Mutch, Nicola J.; Gorog, Diana A. (2022-11-14)Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. ... -
Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19
Gue, Ying X.; Tennyson, Maria; Gao, Jovia; Ren, Shuhui; Kanji, Rahim; Gorog, Diana A. (2020-12-07)Patients hospitalised with COVID-19 have a high mortality. Identification of patients at increased risk of adverse outcome would be important, to allow closer observation and earlier medical intervention for those at risk, ... -
Factor XIa Inhibition: Is It a Novel Alternative Antithrombotic Strategy for High-Risk ACS Patients?
Gue, Ying X.; Gorog, Diana A.; Lip, Gregory Y.H. (2022-10-18) -
Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report
G, Natasha; Chan, Mark; Gue, Ying X.; Gorog, Diana (2019-12-23)Background Taxus baccata, also known as English yew, is a poison that causes cardiac arrhythmias and can result in death from cardiogenic shock.Case summary A 49-year-old gentleman was admitted following yew ingestion with ... -
Fibrinolysis in platelet thrombi
Kanji, Rahim; Gue, Ying X.; Memtsas, Vassilios; Gorog, Diana (2021-05-12)The extent and duration of occlusive thrombus formation following an arterial atherothrombotic plaque disruption may be determined by the effectiveness of endogenous fibrinolysis. The determinants of endogenous fibrinolysis ... -
Impaired endogenous fibrinolysis in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention is a predictor of recurrent cardiovascular events : the RISK PPCI study
Farag, Mohamed; Spinthakis, Nikolaos; Gue, Ying X.; Srinivasan, Manivannan; Sullivan, Keith; Wellsted, David; Gorog, Diana A. (2019-01-14)Aims: The endogenous fibrinolytic system serves to prevent lasting thrombotic occlusion and infarction following initiation of coronary thrombosis. We aimed to determine whether impaired endogenous fibrinolysis can identify ... -
Importance of endogenous fibrinolysis in platelet thrombus formation
Gue, Ying X.; Gorog, Diana A. (2017-09-01)The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous ... -
MINOCA presenting with STEMI – incidence, aetiology and outcome in a contemporaneous cohort
Gue, Ying X.; Corballis, Natasha; Ryding, Alisdair; Kaski, Juan Carlos; Gorog, Diana (2019-11-01)Historical data indicate that approximately 10% of acute coronary syndrome patients have no obstructive coronary artery disease (CAD) but contemporary incidence of non-obstructed coronary arteries in ST-segment elevation ... -
MINOCA presenting with STEMI- a review of incidence, aetiology, assessment and treatment
Gue, Ying X.; Kanji, Rahim; Gati, Sabiha; Gorog, Diana (2020-04-30)Myocardial infarction with non-obstructive coronary artery (MINOCA) is a condition previously thought to be benign but has recently been shown to have comparable mortality to that of acute coronary syndrome with obstructive ... -
Non-Vitamin K Antagonist Oral Anticoagulants versus Warfarin for Patients with Left Ventricular Thrombus: A Systematic Review and Meta-analysis
Gue, Ying X.; Spinthakis, Nikolaos; Egred, Mohaned; Gorog, Diana; Farag, Mohamed (2021-03-01) -
Out-of-hospital cardiac arrest : A systematic review of current risk scores to predict survival
Gue, Ying X.; ADATIA, Krishma; KANJI, Rahim; POTPARA, Tatjana; LIP, Gregory Y.H.; GOROG, Diana A. (2020-12-31)Importance: The arrest and the post-arrest period are an incredibly emotionally traumatic time for family and friends of the affected individual. There is a need to assess prognosis early in the patient pathway to offer ... -
Precision treatment in ACS – role of assessing fibrinolysis
Gue, Ying X.; Jeong, Young-Hoon; Farag, Mohamed; Spinthakis, Nikolaos; Gorog, Diana (2021-03-01)Despite advancements in pharmacotherapy and interventional strategies, patients with acute coronary syndrome (ACS) remain at risk of recurrent thrombotic events. In addition to an enhanced tendency to thrombus formation, ... -
A rare cause of myocardial infarction with non-obstructive coronary arteries-case report of ST-segment elevation myocardial infarction caused by a mediastinal mass
Gue, Ying X.; Anwar, Majid; Gorog, Diana A. (2018-03-01)Introduction ST-segment elevation myocardial infarction (STEMI) is attributable to an occluded coronary artery in almost 90% of patients. Accordingly, restoration of coronary perfusion as early as possible, preferably with ...