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Browsing by Author "Guo, Kai"
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Library Design, Synthesis and Screening : Pyridine Dicarbonitriles as Potential Prion Disease Therapeutics
Reddy, Tummala Rama Krishna; Mutter, Roger; Heal, William; Guo, Kai; Gillet, Valerie J.; Pratt , Steven; Chen, Beining (2006)Transmissible spongiform encephalopathies (TSEs) or prion diseases are a family of invariably fatal neurodegenerative disorders, and there are no effective therapeutics currently available. In this paper, we report on the ... -
Mechanistic studies leading to a new procedure for rapid microwave assisted generation of pyridine-3,5-dicarbonitrile libraries
Guo, Kai; Thompson, Mark J.; Reddy, Tummala Rama Krishna; Mutter , Roger; Chen, Beining (2007-06-11)Mechanistic investigations into the multi-component synthesis of pyridine-3,5-dicarbonitriles have established a defined reaction pathway, particularly clarifying the role of aerobic oxidation in conversion of the intermediate ...