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Browsing by Author "Harrington, L."
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Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function
Bucci, M.; Vellecco, V.; Brancaleone, V.; Roviezzo, F.; Mattace Raso, G.; Ianaro, A.; Meli, R.; Cirino, G.; Harrington, L.; Lungarella, G.; De Palma, R. (2013)Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR and TLR4 in ... -
Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells : Comparison with Toll-like receptor 4 responses in macrophages
Moreno, L.; McMaster, S.K.; Gatheral, T.; Bailey, L.; Harrington, L.; Cartwright, N.; Armstrong, P.C.J.; Warner, T.D.; Paul-Clark, M.; Mitchell, J.A. (2010-08)Background and purpose: Gram-negative bacteria contain ligands for Toll-like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors. Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products ... -
Pharmacology of airways and vessels in lung slices in situ : Role of endogenous dilator hormones
Moreno, L.; Perez-Vizcaino, F.; Harrington, L.; Faro, R.; Sturton, G.; Barnes, P.J.; Mitchell, J.A. (2006-08-21)Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and ... -
Refined Genetic Mapping of the Darier Locus to a <1-cM Region of Chromosome 12q24.1, and Construction of a Complete, High-Resolution P1 Artificial Chromosome/Bacterial Artificial Chromosome Contig of the Critical Region
Monk, S.; Sakuntabhai, A.; Cox, R.; Harrington, L.; Levy, E.; Lathrop, M.; Monaco, A.P.; Hovnanian, A.; Burge, S.; Carter, S.A.; Bryce, S.D.; Ruiz-Perez, V.L.; Katsantoni, E.; Kodvawala, A.; Strachan, T.; Rees, J.L.; Munro, C.S.; Larrègue, M.; Nagy, G. (1998-04)Darier disease (DD) (MIM 124200) is an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and by abnormal keratinization. We present linkage analysis showing, in four families, key ...