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Browsing by Author "Horspool, L. J."
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Determination of short-chain fatty acids in equine caecal liquor by ion exchange high performance liquid chromatography after solid phase extraction
Horspool, L. J.; McKellar, Quintin (1991-09)A high performance liquid chromatography (HPLC) method was developed for the determination of seven short-chain fatty acids in equine caecal liquor. Samples were cleaned up on a Sep-pak (C18) cartridge, and the analyte was ... -
Disposition of ampicillin sodium in horses, ponies and donkeys after intravenous administration
Horspool, L. J.; Sarasola, P.; McKellar, Quintin (1992-02) -
Disposition of oxytetracycline in horses, ponies and donkeys after intravenous administration
Horspool, L. J.; McKellar, Quintin (1990-07) -
Disposition of penicillin G sodium following intravenous and oral administration to Equidae
Horspool, L. J.; McKellar, Quintin (1995)The present study was designed to determine and compare the plasma disposition and pharmacokinetics of penicillin G sodium following intravenous (i.v.) administration to horses, ponies and donkeys. The plasma disposition ... -
Effect of changes in urine pH on plasma pharmacokinetic variables of ampicillin sodium in horses
Sarasola, P.; Horspool, L. J.; McKellar, Quintin (1992)The effect of urine pH on plasma disposition of ampicillin sodium was evaluated. A single dose of 10 mg/kg of body weight was administered IV to Thoroughbreds with alkaline (pH greater than 8.0) or acidic (pH less than ... -
Plasma disposition of amikacin and interactions with gastrointestinal microflora in Equidae following intravenous and oral administration
Horspool, L. J.; Taylor, D. T.; McKellar, Quintin (1994-08)Amikacin was detectable (> 0.02 micrograms/ml) in plasma for 12 h in horses and donkeys and for 8 h in ponies following intravenous (i.v.) administration at a dose rate of 6 mg/kg bodyweight. The elimination half-life ... -
Stability of penicillin G, ampicillin, amikacin and oxytetracycline and their interactions with food in in vitro simulated equine gastrointestinal contents
McKellar, Quintin; Horspool, L. J. (1995-05)Penicillin G was extensively (84.7 per cent) and amikacin moderately (14.4 per cent) degraded when incubated for one hour in a chloride buffer at pH 1.9 designed to mimic the equine gastric pH. Ampicillin and oxytetracycline ...