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Browsing by Author "Hristova, Mariya"
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Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury
Sisa, Claudia; Kholia, Sharad; Naylor, Jordan; Herrera Sanchez, Maria Beatriz; Bruno, Stefania; Deregibus, Maria Chaiara; Camussi, Giovanni; Inal, Jameel; Lange, Sigrun; Hristova, Mariya (2019-03-19)Background: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need ... -
Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?
Lange, Sigrun; Gallagher, Mark; Kholia, Sharad; Kosgodage, Uchini S; Hristova, Mariya; Hardy, John; Inal, Jameel M (2017-06-05)Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from cells and participate in cell-to-cell communication via transport of biological molecules. EMVs play important roles in various pathologies, ... -
A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species
Inal, Jameel M.; Hristova, Mariya; Lange, Sigrun (2022-08-04)PADs are a group of calcium-dependent enzymes that play key roles in inflammatory pathologies and have diverse roles in cancers. PADs cause irreversible post-translational modification of arginine to citrulline, leading ...