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        Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal injury

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        Author
        Sisa, Claudia
        Kholia, Sharad
        Naylor, Jordan
        Herrera Sanchez, Maria Beatriz
        Bruno, Stefania
        Deregibus, Maria Chaiara
        Camussi, Giovanni
        Inal, Jameel
        Lange, Sigrun
        Hristova, Mariya
        Attention
        2299/21209
        Abstract
        Background: Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death in newborns, with therapeutic hypothermia being the only currently available clinical intervention. Thus there is a great need for adjunct and novel treatments for enhanced or alternative post-HI neuroprotection. Extracellular vesicles (EVs) derived from mesenchymal stromal/stem cells (MSCs) have recently been shown to exhibit regenerative effects in various injury models. Here we present findings showing neuroprotective effects of MSC-derived EVs in the Rice-Vannucci model of severe HI-induced neonatal brain insult. Methods: Mesenchymal stromal/stem cell-derived EVs were applied intranasally immediately post HI-insult and behavioral outcomes were observed 48 h following MSC-EV treatment, as assessed by negative geotaxis. Brains were thereafter excised and assessed for changes in glial responses, cell death, and neuronal loss as markers of damage at 48 h post HI-insult. Results: Brains of the MSC-EV treated group showed a significant decrease in microglial activation, cell death, and percentage tissue volume loss in multiple brain regions, compared to the control-treated groups. Furthermore, negative geotaxis test showed improved behavioral outcomes at 48 h following MSC-EV treatment. Conclusion: Our findings highlight the clinical potential of using MSC-derived EVs following neonatal hypoxia-ischaemia.
        Publication date
        2019-03-19
        Published in
        Frontiers in Physiology
        Published version
        https://doi.org/10.3389/fphys.2019.00282
        License
        http://creativecommons.org/licenses/by/4.0/
        Other links
        http://hdl.handle.net/2299/21209
        Relations
        School of Life and Medical Sciences
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