Browsing by Author "Inal, Jameel M"

Now showing items 1-5 of 5

    • Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy 

      Kosgodage, Uchini S; Trindade, Rita P; Thompson, Paul R; Inal, Jameel M; Lange, Sigrun (2017-05-09)
      Microvesicle (MV) release from tumour cells influences drug retention, contributing to cancer drug resistance. Strategically regulating MV release may increase drug retention within cancer cells and allow for lower doses ...

    • Complement C2 receptor inhibitor trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi 

      Cestari, Igor Dos S; Evans-Osses, Ingrid; Freitas, Juliana C; Inal, Jameel M; Ramirez, Marcel I (2008-11-01)
      The ability to resist complement differs between the Y and Colombiana Trypanosoma cruzi strains. We found that the Y strain of T. cruzi was more able to resist the classical and lectin pathways of complement activation ...

    • The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy 

      Moore, Colin; Kosgodage, Uchini; Lange, Sigrun; Inal, Jameel M (2017-08-01)
      There is an urgent need to develop new combination therapies beyond existing surgery, radio- and chemo-therapy, perhaps initially combining chemotherapy with the targeting specificities of immunotherapy. For this, strategies ...

    • Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release? 

      Lange, Sigrun; Gallagher, Mark; Kholia, Sharad; Kosgodage, Uchini S; Hristova, Mariya; Hardy, John; Inal, Jameel M (2017-06-05)
      Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from cells and participate in cell-to-cell communication via transport of biological molecules. EMVs play important roles in various pathologies, ...

    • Vesiclepedia : a compendium for extracellular vesicles with continuous community annotation 

      Kalra, Hina; Simpson, Richard J; Ji, Hong; Aikawa, Elena; Altevogt, Peter; Askenase, Philip; Bond, Vincent C; Borràs, Francesc E; Breakefield, Xandra; Budnik, Vivian; Buzas, Edit; Camussi, Giovanni; Clayton, Aled; Cocucci, Emanuele; Falcon-Perez, Juan M; Gabrielsson, Susanne; Gho, Yong Song; Gupta, Dwijendra; Harsha, H C; Hendrix, An; Hill, Andrew F; Inal, Jameel M; Jenster, Guido; Krämer-Albers, Eva-Maria; Lim, Sai Kiang; Llorente, Alicia; Lötvall, Jan; Marcilla, Antonio; Mincheva-Nilsson, Lucia; Nazarenko, Irina; Nieuwland, Rienk; Nolte-'t Hoen, Esther N M; Pandey, Akhilesh; Patel, Tushar; Piper, Melissa G; Pluchino, Stefano; Prasad, T S Keshava; Rajendran, Lawrence; Raposo, Graca; Record, Michel; Reid, Gavin E; Sánchez-Madrid, Francisco; Schiffelers, Raymond M; Siljander, Pia; Stensballe, Allan; Stoorvogel, Willem; Taylor, Douglas; Thery, Clotilde; Valadi, Hadi; van Balkom, Bas W M; Vázquez, Jesús; Vidal, Michel; Wauben, Marca H M; Yáñez-Mó, María; Zoeller, Margot; Mathivanan, Suresh (2012-12-18)
      Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine ...